{"artifact":{"id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","artifact_type":"experiment","entity_ids":"[\"KLHDC4, APOE\"]","title":"GWAS of plasma NfL in East Asian cohort","quality_score":0.95,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"37a6f415179b19b8a83e8443671fc54c735c4ec362b4a2057a66063b57e39d1f","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-11T00:50:30.877373"},"p_value":null,"protocol":"Illumina Asian Screening Array genotyping, same quality control procedures as other biomarker analyses","effect_size":null,"sample_size":"1,972","source_pmid":"41804841","extracted_at":"2026-04-10T17:50:30.814999","_schema_version":1,"experiment_type":"genetic_association","success_criteria":"genome-wide significance (p < 5×10^-8)","expected_outcomes":"Identification of genetic loci associated with plasma NfL levels in East Asian population","statistical_methods":"genome-wide association analysis"},"created_at":"2026-04-11T00:50:30-07:00","updated_at":"2026-04-11T00:50:30-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-11T00:50:30-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"7e2fead4-5bc8-40f1-b20d-8a86efd5fc60","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-5f260106-156f-4a2c-81f6-c5bcda91b514","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"wiki-APOE","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"target_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-mechanisms-gwas-findings-hub","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GWAS"},{"target_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-cell-types-apoe-expressing-astrocytes","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-therapeutics-apoe-genotype-guided-prevention","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimer's-disease-regulat","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-proteins-nfl-protein","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Neurofilament Light Chain (NFL)"},{"target_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-genes-apoe","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Neurodegeneration"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diagnostics-apoe-genotyping","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-proteins-apoe","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-psen1-mutations","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-mechanisms-gwas-findings","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GWAS"},{"target_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"}],"incoming_links":[{"source_artifact_id":"wiki-proteins-apoe","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"source_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-mechanisms-gwas-findings-hub","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GWAS"},{"source_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-cell-types-apoe-expressing-astrocytes","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-therapeutics-apoe-genotype-guided-prevention","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"source_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimer's-disease-regulat","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-proteins-nfl-protein","link_type":"mentions","strength":0.6,"evidence":"Title match: Neurofilament Light Chain (NFL)"},{"source_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-genes-apoe","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Title match: Neurodegeneration"},{"source_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diagnostics-apoe-genotyping","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-psen1-mutations","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-mechanisms-gwas-findings","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GWAS"},{"source_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.6,"evidence":"Disease match: Alzheimer's disease"}],"current_artifact_id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","is_canonical":true,"supersede_chain":["experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef"]}