{"artifact":{"id":"experiment-exp-1c8d5afa-6af0-4812-864a-c287853f23ca","artifact_type":"experiment","entity_ids":"[\"JUN, TNF\"]","title":"Network pharmacology analysis of QTJD active compounds and pathways","quality_score":0.9,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"13d2cb937aa493aab76a9649f4f6de93e0da1fdf77a0e80e6e48dd56ee9aef40","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-10T22:50:13.603106"},"p_value":null,"protocol":"HPLC-ESI-MS combined with network pharmacology analysis, protein-protein interaction network construction, pathway enrichment analysis","effect_size":null,"sample_size":null,"source_pmid":"41754753","extracted_at":"2026-04-10T15:50:13.600156","_schema_version":1,"experiment_type":"genetic_association","success_criteria":"Identification of biologically relevant compounds and pathways","expected_outcomes":"Identification of key active compounds and signaling pathways mediating QTJD therapeutic effects","statistical_methods":"Network pharmacology algorithms, enrichment analysis"},"created_at":"2026-04-10T22:50:13-07:00","updated_at":"2026-04-10T22:50:13-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T22:50:13-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"f7e6f8cd-2bdb-405e-ab78-4e8d7457ca78","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-genes-tnf","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"wiki-genes-jun","link_type":"related","strength":0.3333333333333333,"evidence":null},{"target_artifact_id":"kg_edge-6d2278d4f270","link_type":"related","strength":0.2,"evidence":null},{"target_artifact_id":"wiki-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Mechanisms"},{"target_artifact_id":"wiki-genes-tnfa","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TNF"},{"target_artifact_id":"wiki-proteins-tnf-alpha-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TNF"},{"target_artifact_id":"wiki-proteins-pi3k-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-proteins-jun-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: JUN"},{"target_artifact_id":"wiki-entities-tnf","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TNF"},{"target_artifact_id":"wiki-proteins-tnf-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TNF"},{"target_artifact_id":"wiki-investment-mapk-signaling-inhibitors","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MAPK"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-mtor-signaling-pathway-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-parkinsons-disease","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-proteins-akt-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: AKT"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-signaling","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-tnf-signaling-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TNF"},{"target_artifact_id":"wiki-mechanisms-mapk-erk-signaling","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MAPK"},{"target_artifact_id":"wiki-proteins-pik3ca-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-mapk-erk-signaling-pathway-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MAPK"},{"target_artifact_id":"wiki-genes-pi3k","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-mapk-signaling-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MAPK"},{"target_artifact_id":"wiki-cell-types-akt-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: AKT"},{"target_artifact_id":"wiki-clinical-trials-pi3k-akt-activator-pd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PI3K"},{"target_artifact_id":"wiki-mechanisms-mapk-jak-stat-signaling-4r-tauopathies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MAPK"},{"target_artifact_id":"wiki-genes-jun","link_type":"mentions","strength":0.5,"evidence":"Entity JUN in experiment"},{"target_artifact_id":"wiki-genes-tnf","link_type":"mentions","strength":0.5,"evidence":"Entity TNF in experiment"}],"incoming_links":[{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-genes-tnfa","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-proteins-tnf-alpha-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-proteins-pi3k-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-proteins-jun-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: JUN"},{"source_artifact_id":"wiki-entities-tnf","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-genes-tnf","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-proteins-tnf-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-investment-mapk-signaling-inhibitors","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MAPK"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-mtor-signaling-pathway-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-genes-jun","link_type":"mentions","strength":0.7,"evidence":"Gene mention: JUN"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-parkinsons-disease","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-proteins-akt-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: AKT"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-signaling","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-tnf-signaling-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TNF"},{"source_artifact_id":"wiki-mechanisms-mapk-erk-signaling","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MAPK"},{"source_artifact_id":"wiki-proteins-pik3ca-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-mapk-erk-signaling-pathway-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MAPK"},{"source_artifact_id":"wiki-genes-pi3k","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-mapk-signaling-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MAPK"},{"source_artifact_id":"wiki-cell-types-akt-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: AKT"},{"source_artifact_id":"wiki-clinical-trials-pi3k-akt-activator-pd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PI3K"},{"source_artifact_id":"wiki-mechanisms-mapk-jak-stat-signaling-4r-tauopathies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MAPK"}],"current_artifact_id":"experiment-exp-1c8d5afa-6af0-4812-864a-c287853f23ca","is_canonical":true,"supersede_chain":["experiment-exp-1c8d5afa-6af0-4812-864a-c287853f23ca"]}