{"artifact":{"id":"experiment-exp-41a0b4b1-9406-4ed5-b496-fb18149232f6","artifact_type":"experiment","entity_ids":"[\"TFEB\"]","title":"Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing mice","quality_score":0.9,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"f4be28d2424258ca08e0245fa9f5fc2a9039b11f7e7fc10236b3a27bbbc794f9","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-10T22:46:09.851735"},"p_value":null,"protocol":"Myocardial infarction induction, cardiac fibroblast isolation, RNA extraction, transcriptome sequencing, differential gene expression analysis using R software","effect_size":null,"sample_size":6,"source_pmid":"41935359","extracted_at":"2026-04-10T15:46:09.847879","_schema_version":1,"experiment_type":"gene_expression","success_criteria":"Significant differential gene expression and pathway enrichment in TFEB overexpressing cells","expected_outcomes":"TFEB would modulate gene expression in cardiac fibroblasts affecting fibrosis-related pathways","statistical_methods":"R software for differential gene expression and functional enrichment analyses"},"created_at":"2026-04-10T22:46:09-07:00","updated_at":"2026-04-10T22:46:09-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T22:46:09-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"7e06b81d-aa65-43b6-af38-b2f250ca1982","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-eb6c3b7d-b813-471c-90bc-79b65b7b6dde","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-b939a41c-0445-4658-bdaf-1f08759e2dc4","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-2141f24c-6948-4c8b-a156-22051d521fd1","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"target_artifact_id":"experiment-exp-6c42097c-1042-4686-bacf-d5adc29cd868","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"target_artifact_id":"wiki-mechanisms-tfeb-activators-parkinsons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-proteins-tfeb","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TFEB"},{"target_artifact_id":"wiki-mechanisms-tfeb-signaling-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TFEB"},{"target_artifact_id":"wiki-therapeutics-tfeb-activators","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TFEB"},{"target_artifact_id":"wiki-therapeutics-tfeb-activators-neurodegeneration","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-mechanisms-tfeb-autophagy-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TFEB"},{"target_artifact_id":"wiki-proteins-tfeb-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TFEB"},{"target_artifact_id":"wiki-therapeutics-tfeb-activator-therapies","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-genes-tfeb","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-mechanisms-lysosomal-biogenesis-tfeb","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-entities-tfeb","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TFEB"},{"target_artifact_id":"wiki-companies-atlasx-bio","link_type":"mentions","strength":0.9,"evidence":"target_gene: TFEB"},{"target_artifact_id":"wiki-genes-tfeb","link_type":"mentions","strength":0.5,"evidence":"Entity TFEB in experiment"}],"incoming_links":[{"source_artifact_id":"experiment-exp-2141f24c-6948-4c8b-a156-22051d521fd1","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"experiment-exp-b939a41c-0445-4658-bdaf-1f08759e2dc4","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"hypothesis-h-e5a1c16b","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"experiment-exp-eb6c3b7d-b813-471c-90bc-79b65b7b6dde","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"experiment-exp-6c42097c-1042-4686-bacf-d5adc29cd868","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'tfeb'"},{"source_artifact_id":"wiki-mechanisms-tfeb-activators-parkinsons","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-proteins-tfeb","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TFEB"},{"source_artifact_id":"wiki-mechanisms-tfeb-signaling-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TFEB"},{"source_artifact_id":"wiki-therapeutics-tfeb-activators","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TFEB"},{"source_artifact_id":"wiki-therapeutics-tfeb-activators-neurodegeneration","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-mechanisms-tfeb-autophagy-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TFEB"},{"source_artifact_id":"wiki-proteins-tfeb-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TFEB"},{"source_artifact_id":"wiki-therapeutics-tfeb-activator-therapies","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-genes-tfeb","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-mechanisms-lysosomal-biogenesis-tfeb","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-entities-tfeb","link_type":"mentions","strength":0.8,"evidence":"Gene target: TFEB"},{"source_artifact_id":"wiki-companies-atlasx-bio","link_type":"mentions","strength":0.9,"evidence":"target_gene: TFEB"}],"current_artifact_id":"experiment-exp-41a0b4b1-9406-4ed5-b496-fb18149232f6","is_canonical":true,"supersede_chain":["experiment-exp-41a0b4b1-9406-4ed5-b496-fb18149232f6"]}