{"artifact":{"id":"experiment-exp-5f1ec586-f80a-4c02-9641-6f9f1d3b363c","artifact_type":"experiment","entity_ids":"[]","title":"GWAS meta-analysis of major depressive disorder across three cohorts","quality_score":0.95,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"297e52cf9cec9b10b71cf3fc4e168e506f983f1660f607f3b7a9cdc56b43bf5b","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-06T12:30:40.932405"},"p_value":5e-08,"protocol":"Genome-wide association analysis followed by meta-analysis across three cohorts with different case ascertainment methods. Statistical analysis using standard GWAS methodology with genome-wide significance threshold of P < 5 × 10^-8.","effect_size":null,"sample_size":336753,"source_pmid":"29728651","extracted_at":"2026-04-06T05:30:40.929261","_schema_version":1,"experiment_type":"genetic_association","success_criteria":"P < 5 × 10^-8 for genome-wide significance","expected_outcomes":"Identification of novel genetic loci associated with MDD risk","statistical_methods":"meta-analysis, genome-wide association testing"},"created_at":"2026-04-06T12:30:40-07:00","updated_at":"2026-04-06T12:30:40-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-06T12:30:40-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"40108a78-3eb1-4573-a353-b6ad533bd4f0","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-proteins-pgc-1alpha","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-proteins-pgc-1a-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-mechanisms-gwas-findings-hub","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GWAS"},{"target_artifact_id":"wiki-proteins-pgc-1-alpha","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-proteins-ppargc1a-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-therapeutics-pgc1-alpha-targeted-therapies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-diseases-depression","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: major depressive disorder"},{"target_artifact_id":"wiki-mechanisms-gwas-findings","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GWAS"},{"target_artifact_id":"wiki-mechanisms-pgc1alpha-parkinsons-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-therapeutics-pgc1-alpha-activator-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"wiki-proteins-ppargc1b-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PGC"},{"target_artifact_id":"paper-29728651","link_type":"derives_from","strength":1.0,"evidence":"Extracted from paper abstract/full text"}],"incoming_links":[{"source_artifact_id":"wiki-diseases-depression","link_type":"related","strength":0.6,"evidence":"Disease match: major depressive disorder"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-proteins-pgc-1alpha","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-proteins-pgc-1a-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-mechanisms-gwas-findings-hub","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GWAS"},{"source_artifact_id":"wiki-proteins-pgc-1-alpha","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-proteins-ppargc1a-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-therapeutics-pgc1-alpha-targeted-therapies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-diseases-depression","link_type":"mentions","strength":0.6,"evidence":"Disease match: major depressive disorder"},{"source_artifact_id":"wiki-mechanisms-gwas-findings","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GWAS"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-parkinsons-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-therapeutics-pgc1-alpha-activator-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"},{"source_artifact_id":"wiki-proteins-ppargc1b-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PGC"}],"current_artifact_id":"experiment-exp-5f1ec586-f80a-4c02-9641-6f9f1d3b363c","is_canonical":true,"supersede_chain":["experiment-exp-5f1ec586-f80a-4c02-9641-6f9f1d3b363c"]}