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wiki/cell-types-striatal-cholinergic-interneurons"},{"source_artifact_id":"wiki-cell-types-edinger-westphal-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-edinger-westphal-nucleus"},{"source_artifact_id":"wiki-cell-types-dorsal-motor-vagus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-dorsal-motor-vagus"},{"source_artifact_id":"wiki-cell-types-facial-nucleus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-facial-nucleus"},{"source_artifact_id":"wiki-cell-types-spinal-ventral-horn-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-spinal-ventral-horn-neurons"},{"source_artifact_id":"wiki-cell-types-septal-nuclei","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 4x in wiki/cell-types-septal-nuclei"},{"source_artifact_id":"wiki-cell-types-cortical-interneurons-vip","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-cortical-interneurons-vip"},{"source_artifact_id":"wiki-cell-types-septal-cholinergic-memory","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-septal-cholinergic-memory"},{"source_artifact_id":"wiki-cell-types-ipsc-derived-cholinergic-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 4x in wiki/cell-types-ipsc-derived-cholinergic-neurons"},{"source_artifact_id":"wiki-cell-types-laterodorsal-tegmental-nucleus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-laterodorsal-tegmental-nucleus"},{"source_artifact_id":"wiki-cell-types-ipsc-derived-motor-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 4x in wiki/cell-types-ipsc-derived-motor-neurons"},{"source_artifact_id":"wiki-cell-types-cell-atlas-markers","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-cell-atlas-markers"},{"source_artifact_id":"wiki-cell-types-nucleus-basalis-meynert-cholinergic-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-nucleus-basalis-meynert-cholinergic-neurons"},{"source_artifact_id":"wiki-cell-types-onufs-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-onufs-nucleus"},{"source_artifact_id":"wiki-cell-types-nucleus-diagonal-band","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 4x in wiki/cell-types-nucleus-diagonal-band"},{"source_artifact_id":"wiki-cell-types-nucleus-ambiguus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-nucleus-ambiguus"},{"source_artifact_id":"wiki-cell-types-cholinergic-neurons-brain","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 4x in wiki/cell-types-cholinergic-neurons-brain"},{"source_artifact_id":"wiki-cell-types-cardiac-intrinsic-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-cardiac-intrinsic-neurons"},{"source_artifact_id":"wiki-cell-types-dinger-westphal-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-dinger-westphal-nucleus"},{"source_artifact_id":"wiki-cell-types-vertical-limb-diagonal-band","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-vertical-limb-diagonal-band"},{"source_artifact_id":"wiki-cell-types-dorsal-motor-nucleus-vagus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 32x in wiki/cell-types-dorsal-motor-nucleus-vagus"},{"source_artifact_id":"wiki-cell-types-substantia-innominata-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-substantia-innominata-neurons"},{"source_artifact_id":"wiki-cell-types-cherne-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 17x in wiki/cell-types-cherne-neurons"},{"source_artifact_id":"wiki-cell-types-pedunculopontine-nucleus-expanded","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 5x in wiki/cell-types-pedunculopontine-nucleus-expanded"},{"source_artifact_id":"wiki-cell-types-cholinergic-basal-forebrain-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-cholinergic-basal-forebrain-neurons"},{"source_artifact_id":"wiki-cell-types-medial-septo-hippocampal-cholinergic","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-medial-septo-hippocampal-cholinergic"},{"source_artifact_id":"wiki-cell-types-medial-septum-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-medial-septum-neurons"},{"source_artifact_id":"wiki-cell-types-basal-forebrain-cholinergic-ds","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/cell-types-basal-forebrain-cholinergic-ds"},{"source_artifact_id":"wiki-cell-types-accessory-nucleus-expanded","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-accessory-nucleus-expanded"},{"source_artifact_id":"wiki-cell-types-nucleus-vertical-limb","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-nucleus-vertical-limb"},{"source_artifact_id":"wiki-cell-types-abducens-nucleus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-abducens-nucleus"},{"source_artifact_id":"wiki-cell-types-taupathology-astrocytes","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/cell-types-taupathology-astrocytes"},{"source_artifact_id":"wiki-cell-types-oculomotor-nucleus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-oculomotor-nucleus"},{"source_artifact_id":"wiki-cell-types-trochlear-nucleus","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-trochlear-nucleus"},{"source_artifact_id":"wiki-cell-types-knockout-cells","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/cell-types-knockout-cells"},{"source_artifact_id":"wiki-cell-types-spinal-motor-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: CHAT mentioned 3x in wiki/cell-types-spinal-motor-neurons"},{"source_artifact_id":"wiki-cell-types-pterygopalatine-ganglion","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-pterygopalatine-ganglion"},{"source_artifact_id":"wiki-cell-types-dorsal-tegmental-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-dorsal-tegmental-nucleus"},{"source_artifact_id":"wiki-cell-types-hypoglossal-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CHAT mentioned 2x in wiki/cell-types-hypoglossal-nucleus"},{"source_artifact_id":"wiki-mechanisms-epigenetics-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-epigenetics-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-blood-ptau217-onset-timing-clock","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-blood-ptau217-onset-timing-clock"},{"source_artifact_id":"wiki-mechanisms-sporadic-alzheimers-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-sporadic-alzheimers-pathway"},{"source_artifact_id":"wiki-mechanisms-calcium-dysregulation-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-calcium-dysregulation-pathway"},{"source_artifact_id":"wiki-mechanisms-gene-mechanism-therapy-causal-chains","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 6x in wiki/mechanisms-gene-mechanism-therapy-causal-chains"},{"source_artifact_id":"wiki-mechanisms-endolysosomal-pathway-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 4x in wiki/mechanisms-endolysosomal-pathway-alzheimers"},{"source_artifact_id":"wiki-mechanisms-protein-aggregation-comparison","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-protein-aggregation-comparison"},{"source_artifact_id":"wiki-mechanisms-5xfad-transgenic-mouse","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 11x in wiki/mechanisms-5xfad-transgenic-mouse"},{"source_artifact_id":"wiki-mechanisms-calcium-dysregulation-ad","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 4x in wiki/mechanisms-calcium-dysregulation-ad"},{"source_artifact_id":"wiki-mechanisms-ad-pd-shared-pathways","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-ad-pd-shared-pathways"},{"source_artifact_id":"wiki-mechanisms-5xfad-mouse","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 8x in wiki/mechanisms-5xfad-mouse"},{"source_artifact_id":"wiki-mechanisms-notch-signaling-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-notch-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-amyloid-cascade-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-amyloid-cascade-pathway"},{"source_artifact_id":"wiki-mechanisms-pretangle-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-pretangle-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-calcium-homeostasis-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-calcium-homeostasis-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-amyloid-vs-tau-first","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 4x in wiki/mechanisms-amyloid-vs-tau-first"},{"source_artifact_id":"wiki-mechanisms-calcium-dysregulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-calcium-dysregulation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-genetics","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 20x in wiki/mechanisms-genetics"},{"source_artifact_id":"wiki-mechanisms-circadian-rhythm-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-circadian-rhythm-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-dian","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/mechanisms-dian"},{"source_artifact_id":"wiki-mechanisms-amyloid-aggregation","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-amyloid-aggregation"},{"source_artifact_id":"wiki-mechanisms-er-stress-upr-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-er-stress-upr-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-alzheimers-pathogenesis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-alzheimers-pathogenesis"},{"source_artifact_id":"wiki-mechanisms-3xtg-ad-mouse","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 6x in wiki/mechanisms-3xtg-ad-mouse"},{"source_artifact_id":"wiki-mechanisms-membrane-trafficking-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-membrane-trafficking-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-amyloid-cascade-hypothesis","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/mechanisms-amyloid-cascade-hypothesis"},{"source_artifact_id":"wiki-mechanisms-autophagy-lysosomal-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-autophagy-lysosomal-comparison"},{"source_artifact_id":"wiki-mechanisms-sorl1-app-trafficking-retromer-ad-causal-chain","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-sorl1-app-trafficking-retromer-ad-causal-chain"},{"source_artifact_id":"wiki-mechanisms-ad-experimental-models-scored","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-ad-experimental-models-scored"},{"source_artifact_id":"wiki-mechanisms-4r-tauopathy-tau-proteostasis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-4r-tauopathy-tau-proteostasis"},{"source_artifact_id":"wiki-mechanisms-amyloid-cascade","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 10x in wiki/mechanisms-amyloid-cascade"},{"source_artifact_id":"wiki-mechanisms-nanomedicine-alzheimers-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-nanomedicine-alzheimers-disease"},{"source_artifact_id":"wiki-mechanisms-autophagy-lysosome-dysfunction","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-autophagy-lysosome-dysfunction"},{"source_artifact_id":"wiki-mechanisms-psen2-presenilin-2-ad-causal-chain","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 14x in wiki/mechanisms-psen2-presenilin-2-ad-causal-chain"},{"source_artifact_id":"wiki-mechanisms-autophagy-lysosomal-impairment-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/mechanisms-autophagy-lysosomal-impairment-comparison"},{"source_artifact_id":"wiki-mechanisms-familial-alzheimers-genetics","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 36x in wiki/mechanisms-familial-alzheimers-genetics"},{"source_artifact_id":"wiki-mechanisms-amyloid-vs-tau-first-hypothesis","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 4x in wiki/mechanisms-amyloid-vs-tau-first-hypothesis"},{"source_artifact_id":"wiki-mechanisms-autophagy-lysosomal-ad","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-autophagy-lysosomal-ad"},{"source_artifact_id":"wiki-mechanisms-amyloid-beta-fibril-formation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/mechanisms-amyloid-beta-fibril-formation-pathway"},{"source_artifact_id":"wiki-mechanisms-rankings","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-rankings"},{"source_artifact_id":"wiki-entities-tau-oligomers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/entities-tau-oligomers"},{"source_artifact_id":"wiki-projects-what-to-work-on","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/projects-what-to-work-on"},{"source_artifact_id":"wiki-technologies-crispr-cas9","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/technologies-crispr-cas9"},{"source_artifact_id":"wiki-technologies-esm-protein-language-model","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/technologies-esm-protein-language-model"},{"source_artifact_id":"wiki-technologies-crispr-gene-editing","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/technologies-crispr-gene-editing"},{"source_artifact_id":"wiki-models-5xfad-transgenic-mouse-model","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/models-5xfad-transgenic-mouse-model"},{"source_artifact_id":"wiki-models-5xfad-mouse","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 8x in wiki/models-5xfad-mouse"},{"source_artifact_id":"wiki-models-3xtg-ad-mouse","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 6x in wiki/models-3xtg-ad-mouse"},{"source_artifact_id":"wiki-biomarkers-blood-ptau217-onset-timing-clock","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/biomarkers-blood-ptau217-onset-timing-clock"},{"source_artifact_id":"wiki-biomarkers-total-tau-t-tau","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/biomarkers-total-tau-t-tau"},{"source_artifact_id":"wiki-biomarkers-amyloid-beta-40-abeta-40","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/biomarkers-amyloid-beta-40-abeta-40"},{"source_artifact_id":"wiki-biomarkers-adpd-2026-precision-medicine-genetic-stratification","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 8x in wiki/biomarkers-adpd-2026-precision-medicine-genetic-stratification"},{"source_artifact_id":"wiki-entities-dian-observational-study","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/entities-dian-observational-study"},{"source_artifact_id":"wiki-entities-tau-pet","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/entities-tau-pet"},{"source_artifact_id":"wiki-entities-app-protein","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/entities-app-protein"},{"source_artifact_id":"wiki-entities-presenilin-1","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 12x in wiki/entities-presenilin-1"},{"source_artifact_id":"wiki-entities-dian-study","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/entities-dian-study"},{"source_artifact_id":"wiki-experiments-dlb-tau-copathology","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/experiments-dlb-tau-copathology"},{"source_artifact_id":"wiki-experiments-toxin-microbiome-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/experiments-toxin-microbiome-parkinsons"},{"source_artifact_id":"wiki-organizations-tau-consortium","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/organizations-tau-consortium"},{"source_artifact_id":"wiki-diseases-tauopathies-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 3x in wiki/diseases-tauopathies-comparison"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: PSEN1 mentioned 5x in wiki/diseases-familial-vs-sporadic-neurodegeneration"},{"source_artifact_id":"wiki-diseases-familial-sporadic-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/diseases-familial-sporadic-neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-classification","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/diseases-disease-classification"},{"source_artifact_id":"wiki-hypotheses-alzheimer's-disease,-biomarker-events-occur","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/hypotheses-alzheimer's-disease,-biomarker-events-occur"},{"source_artifact_id":"wiki-mechanisms-er-mitochondria-contact-sites","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSEN1 mentioned 2x in wiki/mechanisms-er-mitochondria-contact-sites"}],"current_artifact_id":"experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4","is_canonical":true,"supersede_chain":["experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4"]}