{"artifact":{"id":"experiment-exp-8b61762b-2663-4111-9e71-d728137b316c","artifact_type":"experiment","entity_ids":"[\"NFE2L2, HMOX1, TLR4, NFKB1\"]","title":"Resveratrol protection against renal I/R injury in diabetic rats","quality_score":0.9,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"5be1372373fa9d60622960b1d21bfd65c940db54423ac58c22d4a799e60ab8ed","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-11T00:45:03.104229"},"p_value":null,"protocol":"Streptozotocin induction of diabetes in rats, resveratrol pretreatment, renal ischemia/reperfusion induction, assessment of renal function, oxidative stress markers, inflammatory responses, apoptosis, and protein expression levels of Nrf2, HO-1, TLR4, and NF-κB. Selective Nrf2 inhibition with ML385 to confirm mechanism.","effect_size":null,"sample_size":null,"source_pmid":"41958068","extracted_at":"2026-04-10T17:45:03.101026","_schema_version":1,"experiment_type":"animal_model","success_criteria":"Significant improvement in renal function parameters, reduced oxidative stress markers, decreased inflammatory responses and apoptosis, increased Nrf2/HO-1 expression, decreased TLR4/NF-κB expression, and abolishment of benefits with Nrf2 inhibition","expected_outcomes":"RSV treatment expected to improve renal function, reduce oxidative stress and inflammation, decrease apoptosis, increase Nrf2/HO-1 expression, and decrease TLR4/NF-κB expression. ML385 treatment expected to abolish RSV benefits.","statistical_methods":null},"created_at":"2026-04-11T00:45:03-07:00","updated_at":"2026-04-11T00:45:03-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-11T00:45:03-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"2f0573f2-fccc-48b9-ba15-5e0082ee23b2","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-b92b3e79-53a0-47b9-a559-6a9a5a995c13","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"wiki-genes-nfe2l2","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NFE2L2"},{"target_artifact_id":"wiki-genes-tlr4","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TLR4"},{"target_artifact_id":"wiki-proteins-tlr4","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TLR4"},{"target_artifact_id":"wiki-therapeutics-tlr4-antagonists-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TLR4"},{"target_artifact_id":"wiki-genes-hmox1","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: HMOX1"},{"target_artifact_id":"wiki-entities-tlr4","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TLR4"},{"target_artifact_id":"wiki-proteins-nfkb1","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NFKB1"},{"target_artifact_id":"wiki-proteins-hmox1-protein","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: HMOX1"},{"target_artifact_id":"wiki-proteins-tlr4-protein","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TLR4"},{"target_artifact_id":"wiki-genes-nfkb1","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NFKB1"},{"target_artifact_id":"wiki-genes-tlr4","link_type":"mentions","strength":0.5,"evidence":"Entity TLR4 in experiment"}],"incoming_links":[{"source_artifact_id":"experiment-exp-b92b3e79-53a0-47b9-a559-6a9a5a995c13","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"wiki-genes-nfe2l2","link_type":"mentions","strength":0.8,"evidence":"Gene target: NFE2L2"},{"source_artifact_id":"wiki-genes-tlr4","link_type":"mentions","strength":0.8,"evidence":"Gene target: TLR4"},{"source_artifact_id":"wiki-proteins-tlr4","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TLR4"},{"source_artifact_id":"wiki-therapeutics-tlr4-antagonists-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TLR4"},{"source_artifact_id":"wiki-genes-hmox1","link_type":"mentions","strength":0.8,"evidence":"Gene target: HMOX1"},{"source_artifact_id":"wiki-entities-tlr4","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TLR4"},{"source_artifact_id":"wiki-proteins-nfkb1","link_type":"mentions","strength":0.8,"evidence":"Gene target: NFKB1"},{"source_artifact_id":"wiki-proteins-hmox1-protein","link_type":"mentions","strength":0.8,"evidence":"Gene target: HMOX1"},{"source_artifact_id":"wiki-proteins-tlr4-protein","link_type":"mentions","strength":0.8,"evidence":"Gene target: TLR4"},{"source_artifact_id":"wiki-genes-nfkb1","link_type":"mentions","strength":0.8,"evidence":"Gene target: NFKB1"},{"source_artifact_id":"wiki-therapeutics-tgr5-agonist-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/therapeutics-tgr5-agonist-therapy"},{"source_artifact_id":"wiki-therapeutics-heme-oxygenase-1-modulator-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: HMOX1 mentioned 4x in wiki/therapeutics-heme-oxygenase-1-modulator-therapy"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/therapeutics-epigenetic-therapies-parkinsons"},{"source_artifact_id":"wiki-therapeutics-nrf2-activator-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/therapeutics-nrf2-activator-therapy"},{"source_artifact_id":"wiki-clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"source_artifact_id":"wiki-investment-nrf2-therapeutics","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/investment-nrf2-therapeutics"},{"source_artifact_id":"wiki-mechanisms-nrf2-oxidative-stress","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 5x in wiki/mechanisms-nrf2-oxidative-stress"},{"source_artifact_id":"wiki-mechanisms-hypoxia-neuroprotection-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: HMOX1 mentioned 2x in wiki/mechanisms-hypoxia-neuroprotection-parkinsons"},{"source_artifact_id":"wiki-mechanisms-nrf2-parkinsons-disease","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 6x in wiki/mechanisms-nrf2-parkinsons-disease"},{"source_artifact_id":"wiki-mechanisms-nrf2-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 4x in wiki/mechanisms-nrf2-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-arsenic-alzheimer-mechanism","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/mechanisms-arsenic-alzheimer-mechanism"},{"source_artifact_id":"wiki-mechanisms-nrf2-keap1-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFE2L2 mentioned 2x in wiki/mechanisms-nrf2-keap1-pathway"},{"source_artifact_id":"wiki-mechanisms-hpgv-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NFKB1 mentioned 2x in wiki/mechanisms-hpgv-parkinsons"},{"source_artifact_id":"wiki-entities-p62-sqstm1","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 3x in wiki/entities-p62-sqstm1"}],"current_artifact_id":"experiment-exp-8b61762b-2663-4111-9e71-d728137b316c","is_canonical":true,"supersede_chain":["experiment-exp-8b61762b-2663-4111-9e71-d728137b316c"]}