{"artifact":{"id":"experiment-exp-96ca29f6-fdad-46e2-92e2-2c81c00cffd3","artifact_type":"experiment","entity_ids":"[\"GPR109A\"]","title":"Periodontitis-induced colonic inflammation in mice","quality_score":0.9,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"3c04d058f0cb6c3837f8f3c071e1a43a704827158ee78d89adccfb09d2c040a6","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-10T22:49:24.644409"},"p_value":null,"protocol":"Ligature-induced periodontitis in mice, followed by micro-CT analysis, histological evaluation, qPCR, immunostaining, ELISA, and GC-MS/MS analysis of colonic contents","effect_size":null,"sample_size":null,"source_pmid":"41816355","extracted_at":"2026-04-10T15:49:24.641392","_schema_version":1,"experiment_type":"animal_model","success_criteria":"Significant changes in GPR109A expression, tight junction protein localization, and inflammatory markers","expected_outcomes":"Periodontitis would downregulate GPR109A expression and disrupt intestinal barrier function","statistical_methods":null},"created_at":"2026-04-10T22:49:24-07:00","updated_at":"2026-04-10T22:49:24-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T22:49:24-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"654c46b1-1d7e-4db9-ae9c-e67953f73675","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-fa0d03e3-261c-4eac-8f67-b02263a7a267","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-cafc6e59-f753-4298-bee2-7b0dc9047ff2","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-35dc17bb-762a-401b-beb3-c4899ef58ce2","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"wiki-therapeutics-gpr109a-agonists-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GPR109A"}],"incoming_links":[{"source_artifact_id":"experiment-exp-35dc17bb-762a-401b-beb3-c4899ef58ce2","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-fa0d03e3-261c-4eac-8f67-b02263a7a267","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-cafc6e59-f753-4298-bee2-7b0dc9047ff2","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'gpr109a'"},{"source_artifact_id":"wiki-therapeutics-gpr109a-agonists-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GPR109A"},{"source_artifact_id":"wiki-therapeutics-microbiome-metabolomics-scfa-therapy-cbs-psp","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPR109A mentioned 2x in wiki/therapeutics-microbiome-metabolomics-scfa-therapy-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-section-182-microbiome-metabolomics-scfa-therapy-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: GPR109A mentioned 4x in wiki/therapeutics-section-182-microbiome-metabolomics-scfa-therapy-cbs-psp"},{"source_artifact_id":"wiki-mechanisms-short-chain-fatty-acids","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPR109A mentioned 2x in wiki/mechanisms-short-chain-fatty-acids"}],"current_artifact_id":"experiment-exp-96ca29f6-fdad-46e2-92e2-2c81c00cffd3","is_canonical":true,"supersede_chain":["experiment-exp-96ca29f6-fdad-46e2-92e2-2c81c00cffd3"]}