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wiki/therapeutics-stem-cell-therapy-parkinsonism"},{"source_artifact_id":"wiki-therapeutics-omega-3-fatty-acids-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-omega-3-fatty-acids-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-anti-amyloid-immunotherapy-comparison","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-anti-amyloid-immunotherapy-comparison"},{"source_artifact_id":"wiki-therapeutics-section-201-mitochondrial-biogenesis-pgc1alpha-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 12x in wiki/therapeutics-section-201-mitochondrial-biogenesis-pgc1alpha-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-specialized-pro-resolving-mediator-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-specialized-pro-resolving-mediator-therapy"},{"source_artifact_id":"wiki-therapeutics-anti-tau-immunotherapies","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-anti-tau-immunotherapies"},{"source_artifact_id":"wiki-therapeutics-ceramide-sphingolipid-modulation-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-ceramide-sphingolipid-modulation-therapy"},{"source_artifact_id":"wiki-therapeutics-ampk-activators-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-ampk-activators-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-section-135-telomere-biology-anti-aging-cbs-psp","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-section-135-telomere-biology-anti-aging-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-metabolic-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-metabolic-therapy"},{"source_artifact_id":"wiki-therapeutics-cd38-inhibitor-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/therapeutics-cd38-inhibitor-therapy-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-ferulic-acid-carbamate-derivatives-ad","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-ferulic-acid-carbamate-derivatives-ad"},{"source_artifact_id":"wiki-therapeutics-nanomedicine-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-nanomedicine-alzheimers"},{"source_artifact_id":"wiki-therapeutics-cbs-psp-treatment-rankings","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-cbs-psp-treatment-rankings"},{"source_artifact_id":"wiki-therapeutics-section-103-sirtuin-nad-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 29x in wiki/therapeutics-section-103-sirtuin-nad-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-ampk-activators","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-ampk-activators"},{"source_artifact_id":"wiki-therapeutics-nicotinamide-mononucleotide-nmn","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/therapeutics-nicotinamide-mononucleotide-nmn"},{"source_artifact_id":"wiki-therapeutics-memantine","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-memantine"},{"source_artifact_id":"wiki-therapeutics-nanomedicine-alzheimers-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-nanomedicine-alzheimers-disease"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons-disease","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 9x in wiki/therapeutics-epigenetic-therapies-parkinsons-disease"},{"source_artifact_id":"wiki-therapeutics-calorie-restriction-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/therapeutics-calorie-restriction-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-autophagy-enhancers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-autophagy-enhancers"},{"source_artifact_id":"wiki-therapeutics-coenzyme-q10-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/therapeutics-coenzyme-q10-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-pyroptosis-modulation-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/therapeutics-pyroptosis-modulation-therapy"},{"source_artifact_id":"wiki-therapeutics-natural-compounds-phyto-therapy-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-natural-compounds-phyto-therapy-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-physical-therapy-atypical-parkinsonism","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-physical-therapy-atypical-parkinsonism"},{"source_artifact_id":"wiki-therapeutics-pgc1-alpha-activator-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-pgc1-alpha-activator-therapy"},{"source_artifact_id":"wiki-therapeutics-mitochondrial-therapies-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-mitochondrial-therapies-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-nad-boosters","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/therapeutics-nad-boosters"},{"source_artifact_id":"wiki-therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-mitophagy-activators","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-mitophagy-activators"},{"source_artifact_id":"wiki-therapeutics-resveratrol-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 16x in wiki/therapeutics-resveratrol-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-iron-chelation-therapy-parkinsons-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FTH1 mentioned 2x in wiki/therapeutics-iron-chelation-therapy-parkinsons-disease"},{"source_artifact_id":"wiki-therapeutics-iron-chelation-therapy-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 4x in wiki/therapeutics-iron-chelation-therapy-parkinsons"},{"source_artifact_id":"wiki-therapeutics-nad-precursor-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 11x in wiki/therapeutics-nad-precursor-therapy"},{"source_artifact_id":"wiki-clinical-trials-tocotrienols-pd-nct04491383","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/clinical-trials-tocotrienols-pd-nct04491383"},{"source_artifact_id":"wiki-clinical-trials-alzheimers-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/clinical-trials-alzheimers-disease"},{"source_artifact_id":"wiki-clinical-trials-coq10-qe3","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/clinical-trials-coq10-qe3"},{"source_artifact_id":"wiki-clinical-trials-nadapt-study-nad-replenishment-parkinsonism-nct06162013","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/clinical-trials-nadapt-study-nad-replenishment-parkinsonism-nct06162013"},{"source_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/clinical-trials-nct07062198"},{"source_artifact_id":"wiki-hypotheses-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: ACSL4 mentioned 3x in wiki/hypotheses-oligodendrocyte-myelin-dysfunction-parkinsons"},{"source_artifact_id":"wiki-hypotheses-sirtuin-pathway-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 41x in wiki/hypotheses-sirtuin-pathway-dysfunction-parkinsons"},{"source_artifact_id":"wiki-hypotheses-ferroptosis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 19x in wiki/hypotheses-ferroptosis-parkinsons"},{"source_artifact_id":"wiki-circuits-alzheimer-hippocampal-circuit","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/circuits-alzheimer-hippocampal-circuit"},{"source_artifact_id":"wiki-ideas-cd38-inhibition-nad-synergy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/ideas-cd38-inhibition-nad-synergy"},{"source_artifact_id":"wiki-ideas-mitochondrial-nad-redox-swing-protocol","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"source_artifact_id":"wiki-ideas-payload-insulin-glp1-combo-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-insulin-glp1-combo-therapy"},{"source_artifact_id":"wiki-ideas-combination-logic-ideas","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-combination-logic-ideas"},{"source_artifact_id":"wiki-ideas-novel-therapy-index","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/ideas-novel-therapy-index"},{"source_artifact_id":"wiki-ideas-payload-iron-chelation-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FTH1 mentioned 2x in wiki/ideas-payload-iron-chelation-neurodegeneration"},{"source_artifact_id":"wiki-ideas-parp1-inhibition-parthanatos-prevention","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/ideas-parp1-inhibition-parthanatos-prevention"},{"source_artifact_id":"wiki-ideas-payload-mitochondrial-nad-redox-swing","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 14x in wiki/ideas-payload-mitochondrial-nad-redox-swing"},{"source_artifact_id":"wiki-ideas-payload-ferroptosis-inhibitor","link_type":"mentions","strength":0.5,"evidence":"Content: ACSL4 mentioned 5x in wiki/ideas-payload-ferroptosis-inhibitor"},{"source_artifact_id":"wiki-ideas-payload-epigenetic-clock-reversal-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-epigenetic-clock-reversal-therapy"},{"source_artifact_id":"wiki-ideas-fsp1-coq10-redox-augmentation","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 18x in wiki/ideas-fsp1-coq10-redox-augmentation"},{"source_artifact_id":"wiki-ideas-payload-m6a-rna-methylation-modulation-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-m6a-rna-methylation-modulation-therapy"},{"source_artifact_id":"wiki-ideas-payload-crmp2-phosphorylation-modulation-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-crmp2-phosphorylation-modulation-therapy"},{"source_artifact_id":"wiki-ideas-combo-sirt1-nad-epigenetic-metabolic","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 64x in wiki/ideas-combo-sirt1-nad-epigenetic-metabolic"},{"source_artifact_id":"wiki-ideas-payload-checkpoint-kinase-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/ideas-payload-checkpoint-kinase-modulation-therapy"},{"source_artifact_id":"wiki-ideas-payload-notch-signaling-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/ideas-payload-notch-signaling-modulation-therapy"},{"source_artifact_id":"wiki-ideas-ulnk1-2-kinase-modulation-mitophagy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-ulnk1-2-kinase-modulation-mitophagy"},{"source_artifact_id":"wiki-ideas-mitochondrial-nad-redox-swing","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 6x in wiki/ideas-mitochondrial-nad-redox-swing"},{"source_artifact_id":"wiki-investment-sirtuin-therapeutics-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 20x in wiki/investment-sirtuin-therapeutics-neurodegeneration"},{"source_artifact_id":"wiki-investment-oxidative-stress","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/investment-oxidative-stress"},{"source_artifact_id":"wiki-investment-ferroptosis-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 17x in wiki/investment-ferroptosis-neurodegeneration"},{"source_artifact_id":"wiki-investment-oxidative-stress-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/investment-oxidative-stress-neurodegeneration"},{"source_artifact_id":"wiki-investment-epigenetic-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 8x in wiki/investment-epigenetic-therapy-neurodegeneration"},{"source_artifact_id":"wiki-cell-types-striatum-procedural-memory","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-striatum-procedural-memory"},{"source_artifact_id":"wiki-cell-types-spinal-interneurons-motor-neuron-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-spinal-interneurons-motor-neuron-disease"},{"source_artifact_id":"wiki-cell-types-resilient-neurons-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-resilient-neurons-alzheimers"},{"source_artifact_id":"wiki-cell-types-caudate-nucleus-projection","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FOXO3 mentioned 2x in wiki/cell-types-caudate-nucleus-projection"},{"source_artifact_id":"wiki-cell-types-glucose-metabolism-vulnerable-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-glucose-metabolism-vulnerable-neurons"},{"source_artifact_id":"wiki-cell-types-mitochondrial-dysfunction-dopaminergic","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FOXO3 mentioned 2x in wiki/cell-types-mitochondrial-dysfunction-dopaminergic"},{"source_artifact_id":"wiki-cell-types-circadian-neurons-in-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/cell-types-circadian-neurons-in-neurodegeneration"},{"source_artifact_id":"wiki-cell-types-circadian-dysfunction-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-circadian-dysfunction-neurons"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-expanded","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-ventral-tegmental-area-expanded"},{"source_artifact_id":"wiki-cell-types-ferroptosis-sensitive-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 7x in wiki/cell-types-ferroptosis-sensitive-neurons"},{"source_artifact_id":"wiki-cell-types-telomere-dysfunction-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-telomere-dysfunction-neurons"},{"source_artifact_id":"wiki-cell-types-ferroptotic-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 40x in wiki/cell-types-ferroptotic-neurons"},{"source_artifact_id":"wiki-cell-types-cerebellar-purkinje-cells-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-cerebellar-purkinje-cells-disease"},{"source_artifact_id":"wiki-cell-types-pedunculopontine-nucleus-cholinergic-neurons-in-lewy-body-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-pedunculopontine-nucleus-cholinergic-neurons-in-lewy-body-disease"},{"source_artifact_id":"wiki-cell-types-pedunculopontine-nucleus-neurons-lewy-body-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-pedunculopontine-nucleus-neurons-lewy-body-disease"},{"source_artifact_id":"wiki-cell-types-cerebellar-neurons-creutzfeldt-jakob-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-cerebellar-neurons-creutzfeldt-jakob-disease"},{"source_artifact_id":"wiki-cell-types-endothelial-cells-cerebral","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 4x in wiki/cell-types-endothelial-cells-cerebral"},{"source_artifact_id":"wiki-cell-types-circadian-clock-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-circadian-clock-neurons"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-ventral-tegmental-area"},{"source_artifact_id":"wiki-cell-types-aging-oligodendrocytes","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-aging-oligodendrocytes"},{"source_artifact_id":"wiki-cell-types-aging-microglia","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-aging-microglia"},{"source_artifact_id":"wiki-cell-types-cerebellar-granule-cells-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/cell-types-cerebellar-granule-cells-disease"},{"source_artifact_id":"wiki-mechanisms-epigenetics-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetics-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-metal-homeostasis-dysregulation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/mechanisms-metal-homeostasis-dysregulation"},{"source_artifact_id":"wiki-mechanisms-sirtuins-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 28x in wiki/mechanisms-sirtuins-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-quality-control-network-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitochondrial-quality-control-network-pathway"},{"source_artifact_id":"wiki-mechanisms-ampk-signaling-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-ampk-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-metal-homeostasis-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: FTH1 mentioned 3x in wiki/mechanisms-metal-homeostasis-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-pathway"},{"source_artifact_id":"wiki-mechanisms-nfkb-signaling-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-nfkb-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-sirtuin-mitochondrial-biogenesis-axis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 24x in wiki/mechanisms-sirtuin-mitochondrial-biogenesis-axis"},{"source_artifact_id":"wiki-mechanisms-astrocyte-senescence-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-astrocyte-senescence-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-lipid-peroxidation-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: ACSL4 mentioned 15x in wiki/mechanisms-ferroptosis-lipid-peroxidation-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-dna-damage-ad-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-dna-damage-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-hub","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-hub"},{"source_artifact_id":"wiki-mechanisms-nrf2-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-nrf2-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-regulation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetic-regulation"},{"source_artifact_id":"wiki-mechanisms-neuronal-death-ad","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 8x in wiki/mechanisms-neuronal-death-ad"},{"source_artifact_id":"wiki-mechanisms-histone-modification-pathway-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-histone-modification-pathway-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-ampk-mitochondrial-quality-control","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-ampk-mitochondrial-quality-control"},{"source_artifact_id":"wiki-mechanisms-synthetic-lethality-parp-inhibition","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 15x in wiki/mechanisms-synthetic-lethality-parp-inhibition"},{"source_artifact_id":"wiki-mechanisms-metal-ion-homeostasis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 7x in wiki/mechanisms-metal-ion-homeostasis-parkinsons"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 35x in wiki/mechanisms-ferroptosis-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-circadian-dysfunction-ad-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-circadian-dysfunction-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-iron-homeostasis-dysregulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: FTH1 mentioned 3x in wiki/mechanisms-iron-homeostasis-dysregulation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-chrononutrition-time-restricted-eating","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 11x in wiki/mechanisms-chrononutrition-time-restricted-eating"},{"source_artifact_id":"wiki-mechanisms-neuroresilience","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-neuroresilience"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-ad-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-neuroimmune-metabolic-convergence-therapy-synthesis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-neuroimmune-metabolic-convergence-therapy-synthesis"},{"source_artifact_id":"wiki-mechanisms-iron-metabolism-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FTH1 mentioned 2x in wiki/mechanisms-iron-metabolism-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-ivns1abp-mutation-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/mechanisms-ivns1abp-mutation-disease"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 54x in wiki/mechanisms-sirtuin-signaling-parkinsons"},{"source_artifact_id":"wiki-mechanisms-target-family-consolidation-analysis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-target-family-consolidation-analysis"},{"source_artifact_id":"wiki-mechanisms-citric-acid-cycle","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-citric-acid-cycle"},{"source_artifact_id":"wiki-mechanisms-psp-ferroptosis-iron-dependent-cell-death","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 29x in wiki/mechanisms-psp-ferroptosis-iron-dependent-cell-death"},{"source_artifact_id":"wiki-mechanisms-creb-independent-neuronal-survival-pathways","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-creb-independent-neuronal-survival-pathways"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 23x in wiki/mechanisms-ferroptosis-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: SLC7A11 mentioned 4x in wiki/mechanisms-ferroptosis-alzheimers"},{"source_artifact_id":"wiki-mechanisms-iron-dysregulation","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 3x in wiki/mechanisms-iron-dysregulation"},{"source_artifact_id":"wiki-mechanisms-aging-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-aging-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-heat-shock-protein-response-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-heat-shock-protein-response-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-transcriptional-regulation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-transcriptional-regulation"},{"source_artifact_id":"wiki-mechanisms-geroprotective-therapies-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-geroprotective-therapies-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-alpha-synuclein-autophagy-clearance","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-alpha-synuclein-autophagy-clearance"},{"source_artifact_id":"wiki-mechanisms-oxidative-stress-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 8x in wiki/mechanisms-oxidative-stress-pathway"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-neurodegeneration-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 27x in wiki/mechanisms-ferroptosis-neurodegeneration-pathway"},{"source_artifact_id":"wiki-mechanisms-adiponectin-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-adiponectin-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-psp-epigenetic-changes","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-psp-epigenetic-changes"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-ad-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 23x in wiki/mechanisms-ferroptosis-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-alterations-ad","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-epigenetic-alterations-ad"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 64x in wiki/mechanisms-sirtuin-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 31x in wiki/mechanisms-ferroptosis-pathway"},{"source_artifact_id":"wiki-mechanisms-foxo-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: FOXO3 mentioned 10x in wiki/mechanisms-foxo-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-circadian-disruption-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-circadian-disruption-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-chromatin-remodeling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-nad-metabolism-pathway-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 17x in wiki/mechanisms-nad-metabolism-pathway-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 9x in wiki/mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 38x in wiki/mechanisms-sirtuin-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitochondrial-dysfunction-parkinsons"},{"source_artifact_id":"wiki-mechanisms-metal-ion-synuclein-mitochondria-axis","link_type":"mentions","strength":0.5,"evidence":"Content: FTH1 mentioned 3x in wiki/mechanisms-metal-ion-synuclein-mitochondria-axis"},{"source_artifact_id":"wiki-mechanisms-sleep-circadian-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-sleep-circadian-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis"},{"source_artifact_id":"wiki-mechanisms-mitophagy-defect","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitophagy-defect"},{"source_artifact_id":"wiki-mechanisms-epigenetic-disease-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 9x in wiki/mechanisms-epigenetic-disease-comparison"},{"source_artifact_id":"wiki-mechanisms-nrf2-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-nrf2-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-energy-metabolism-dysfunction-comparison","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-energy-metabolism-dysfunction-comparison"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-clocks-brain-aging","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetic-clocks-brain-aging"},{"source_artifact_id":"wiki-mechanisms-metal-homeostasis-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 7x in wiki/mechanisms-metal-homeostasis-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-nad-metabolism-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 16x in wiki/mechanisms-nad-metabolism-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-pink1-parkin-mitophagy-activators-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-pink1-parkin-mitophagy-activators-parkinsons"},{"source_artifact_id":"wiki-mechanisms-lipid-peroxidation-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/mechanisms-lipid-peroxidation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitophagy-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitophagy-pathway"},{"source_artifact_id":"wiki-mechanisms-transcription-regulation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-transcription-regulation"},{"source_artifact_id":"wiki-mechanisms-cross-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/mechanisms-cross-disease"},{"source_artifact_id":"wiki-mechanisms-mitochondria-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondria-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-nfkb-signaling-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-nfkb-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-lrrk2-signaling-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/mechanisms-lrrk2-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-circadian-disruption-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-circadian-disruption-parkinsons"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-ad","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 52x in wiki/mechanisms-ferroptosis-ad"},{"source_artifact_id":"wiki-mechanisms-ampk-activators-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-ampk-activators-parkinsons"},{"source_artifact_id":"wiki-mechanisms-nad-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-nad-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 24x in wiki/mechanisms-sirtuin-signaling-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-circadian-rhythm-dysfunction-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-circadian-rhythm-dysfunction-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-lactoferrin-neuroprotection","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 5x in wiki/mechanisms-lactoferrin-neuroprotection"},{"source_artifact_id":"wiki-mechanisms-tfeb-autophagy-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-tfeb-autophagy-pathway"},{"source_artifact_id":"wiki-mechanisms-rna-metabolism-alzheimers-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-rna-metabolism-alzheimers-disease"},{"source_artifact_id":"wiki-mechanisms-ferroptosis","link_type":"mentions","strength":0.5,"evidence":"Content: ACSL4 mentioned 10x in wiki/mechanisms-ferroptosis"},{"source_artifact_id":"wiki-mechanisms-cerebrovascular-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/mechanisms-cerebrovascular-disease"},{"source_artifact_id":"wiki-mechanisms-lactate-lactylation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 9x in wiki/mechanisms-lactate-lactylation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-epigenetics-als","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetics-als"},{"source_artifact_id":"wiki-mechanisms-autophagy-bioactive-compounds","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-autophagy-bioactive-compounds"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 12x in wiki/mechanisms-chromatin-remodeling"},{"source_artifact_id":"wiki-mechanisms-rna-dysregulation-ad","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-rna-dysregulation-ad"},{"source_artifact_id":"wiki-mechanisms-iron-accumulation-psp","link_type":"mentions","strength":0.5,"evidence":"Content: FTH1 mentioned 3x in wiki/mechanisms-iron-accumulation-psp"},{"source_artifact_id":"wiki-mechanisms-lipid-peroxidation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GPX4 mentioned 2x in wiki/mechanisms-lipid-peroxidation"},{"source_artifact_id":"wiki-mechanisms-glutathione-metabolism","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 18x in wiki/mechanisms-glutathione-metabolism"},{"source_artifact_id":"wiki-mechanisms-epigenetics-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetics-parkinsons"},{"source_artifact_id":"wiki-mechanisms-circadian-rhythm-disruption-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-circadian-rhythm-disruption-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-unfolded-protein-response","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-mitochondrial-unfolded-protein-response"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-disease-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 16x in wiki/mechanisms-ferroptosis-disease-comparison"},{"source_artifact_id":"wiki-mechanisms-iron-accumulation-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 6x in wiki/mechanisms-iron-accumulation-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-parkinsons-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-pgc1alpha-parkinsons-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetic-dysregulation-comparison"},{"source_artifact_id":"wiki-mechanisms-alpha-klotho-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-alpha-klotho-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: ACSL4 mentioned 7x in wiki/mechanisms-ferroptosis-parkinsons"},{"source_artifact_id":"wiki-mechanisms-huntingtin-mitochondrial-dysfunction","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-huntingtin-mitochondrial-dysfunction"},{"source_artifact_id":"wiki-mechanisms-energy-metabolism-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-energy-metabolism-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-dna-damage-response-parkinsons"},{"source_artifact_id":"wiki-mechanisms-hdac-inhibitor-mechanism","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-hdac-inhibitor-mechanism"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-quality-control","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-quality-control"},{"source_artifact_id":"wiki-mechanisms-ad-epigenetic-alterations-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 12x in wiki/mechanisms-ad-epigenetic-alterations-pathway"},{"source_artifact_id":"wiki-mechanisms-nad-bioenergetics-investment-synthesis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-nad-bioenergetics-investment-synthesis"},{"source_artifact_id":"wiki-technologies-p300-bci","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FOXO3 mentioned 2x in wiki/technologies-p300-bci"},{"source_artifact_id":"wiki-technologies-wearable-sensors-parkinsonism","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/technologies-wearable-sensors-parkinsonism"},{"source_artifact_id":"wiki-entities-mitochondrial-dynamics","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/entities-mitochondrial-dynamics"},{"source_artifact_id":"wiki-entities-hdac-enzymes","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 6x in wiki/entities-hdac-enzymes"},{"source_artifact_id":"wiki-entities-histone-deacetylase","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/entities-histone-deacetylase"},{"source_artifact_id":"wiki-entities-rnf128","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 28x in wiki/entities-rnf128"},{"source_artifact_id":"wiki-entities-ampk","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 3x in wiki/entities-ampk"},{"source_artifact_id":"wiki-brain-regions-brainstem","link_type":"mentions","strength":0.5,"evidence":"Content: FOXO3 mentioned 3x in wiki/brain-regions-brainstem"},{"source_artifact_id":"wiki-brain-regions-ventral-tegmental-area","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/brain-regions-ventral-tegmental-area"},{"source_artifact_id":"wiki-experiments-sirtuin-pathway-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 9x in wiki/experiments-sirtuin-pathway-dysfunction-parkinsons"},{"source_artifact_id":"wiki-experiments-iron-dyshomeostasis-msa-pathogenesis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: FTH1 mentioned 2x in wiki/experiments-iron-dyshomeostasis-msa-pathogenesis"},{"source_artifact_id":"wiki-experiments-sirtuin-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 14x in wiki/experiments-sirtuin-dysfunction-parkinsons"},{"source_artifact_id":"wiki-experiments-circadian-vascular-metabolic-syndrome-ad","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SIRT1 mentioned 2x in wiki/experiments-circadian-vascular-metabolic-syndrome-ad"},{"source_artifact_id":"wiki-experiments-ferroptosis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 4x in wiki/experiments-ferroptosis-parkinsons"},{"source_artifact_id":"wiki-diseases-cockayne-syndrome","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 4x in wiki/diseases-cockayne-syndrome"},{"source_artifact_id":"wiki-diseases-cardiomyopathy","link_type":"mentions","strength":0.5,"evidence":"Content: GPX4 mentioned 3x in wiki/diseases-cardiomyopathy"},{"source_artifact_id":"wiki-diseases-neuroferritinopathy","link_type":"mentions","strength":0.5,"evidence":"Content: FTH1 mentioned 5x in wiki/diseases-neuroferritinopathy"},{"source_artifact_id":"wiki-entities-ppar","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ACSL4 mentioned 2x in wiki/entities-ppar"}],"current_artifact_id":"experiment-exp-9f358501-0c3d-417e-9b43-1be792ee3638","is_canonical":true,"supersede_chain":["experiment-exp-9f358501-0c3d-417e-9b43-1be792ee3638"]}