{"artifact":{"id":"experiment-exp-afe1d470-63a3-44e9-b882-44f89779a907","artifact_type":"experiment","entity_ids":"[\"St8sia1\"]","title":"Abeta-induced cell death and aggregation in GD3S-deficient neurons","quality_score":0.85,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"048e90c305a51d68beec0d28fcf28cd190e702e75a4c754b0d284a059077df58","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-10T22:32:02.709263"},"p_value":null,"protocol":"Primary cell culture from GD3S knockout mice, Abeta exposure, cell viability and aggregation assays","effect_size":null,"sample_size":null,"source_pmid":"18258340","extracted_at":"2026-04-10T15:32:02.705335","_schema_version":1,"experiment_type":"cell_biology","success_criteria":"Significant reduction in cell death and Abeta aggregation compared to wild-type controls","expected_outcomes":"Reduced Abeta-induced cell death and aggregation in GD3S-deficient cells","statistical_methods":null},"created_at":"2026-04-10T22:32:02-07:00","updated_at":"2026-04-10T22:32:02-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T22:32:02-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"10693dc9-37c7-4d6b-96e7-232274783e16","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-8611f56b-0e18-40e2-a0d4-0be2bff633ec","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-4c97be59-973e-4997-bca9-8c28a6affaa8","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-psen1-mutations","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-entities-astrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Astrocytes"},{"target_artifact_id":"wiki-gd3-synthase","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: GD3"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-cell-types-astrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Astrocytes"},{"target_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"}],"incoming_links":[{"source_artifact_id":"experiment-exp-8611f56b-0e18-40e2-a0d4-0be2bff633ec","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-4c97be59-973e-4997-bca9-8c28a6affaa8","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-psen1-mutations","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-entities-astrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Astrocytes"},{"source_artifact_id":"wiki-gd3-synthase","link_type":"mentions","strength":0.7,"evidence":"Gene mention: GD3"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-cell-types-astrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Astrocytes"},{"source_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.6,"evidence":"Disease match: Alzheimer's disease"},{"source_artifact_id":"wiki-mechanisms-sphingolipid-metabolism-4r-tauopathies","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ST8SIA1 mentioned 2x in wiki/mechanisms-sphingolipid-metabolism-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-ganglioside-lipid-raft-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: ST8SIA1 mentioned 3x in wiki/mechanisms-ganglioside-lipid-raft-4r-tauopathies"},{"source_artifact_id":"wiki-technologies-memory-prosthetic-bci","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: ST8SIA1 mentioned 2x in wiki/technologies-memory-prosthetic-bci"},{"source_artifact_id":"open_question-abceda22-4a30-40e7-8a4f-c9e2ca6100e1","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-8d98953b-229f-4da7-b50b-3bbf3f49a2b4","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"experiment-exp-afe1d470-63a3-44e9-b882-44f89779a907","is_canonical":true,"supersede_chain":["experiment-exp-afe1d470-63a3-44e9-b882-44f89779a907"]}