{"artifact":{"id":"experiment-exp-bf66d02f24c1","artifact_type":"experiment","entity_ids":null,"title":"Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, a","quality_score":0.5,"created_by":"experiment_extractor","provenance_chain":null,"content_hash":null,"metadata":{"source":{"pmid":"39402379","type":"paper","extracted_by":"llm_extraction_v1"},"tissue":"middle temporal gyrus","species":"homo_sapiens","summary":"Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, and Pvalb+/Vip+ inhibitory neuron subtype loss.","sample_size":{"case":null,"total":84,"units":"subjects","control":null},"model_system":"human","_schema_version":1,"experiment_type":"computational","methodology_notes":"Multiomics, spatial genomics, and quantitative neuropathology applied to BRAIN Initiative reference atlases. Donors (33 male, 51 female; mean age 88) were stratified using a disease pseudoprogression score based on neuropathology.","replication_status":"replicated","extraction_metadata":{"needs_review":false,"extraction_date":"2026-04-28T06:21:38.643090+00:00","extraction_notes":"","extraction_confidence":0.5},"statistical_evidence":null},"created_at":null,"updated_at":null,"version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"cb27e52e-202c-4aed-aab5-4c3ea56ed422","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"experiment-exp-bf66d02f24c1","is_canonical":true,"supersede_chain":["experiment-exp-bf66d02f24c1"]}