{"artifact":{"id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","artifact_type":"experiment","entity_ids":"[\"APOE\"]","title":"KEEPS Continuation: Long-term effects of menopausal hormone therapy on AD biomarkers","quality_score":0.95,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"d68bc4928adfc01f23a08ce8c7225f52443bff0d38a095fb8e340c9aa8671813","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-11T00:48:06.090741"},"p_value":null,"protocol":"Participants from the original KEEPS trial were recontacted 10 years after completion. Amyloid beta burden was assessed using positron emission tomography. Structural MRI was performed to measure hippocampal atrophy and dorsolateral prefrontal cortex thickness. APOE ε4 genotyping was performed to assess genetic modifying effects.","effect_size":null,"sample_size":"266","source_pmid":"41618732","extracted_at":"2026-04-10T17:48:06.087945","_schema_version":1,"experiment_type":"clinical_trial","success_criteria":"Differences in amyloid beta burden and structural MRI biomarkers between hormone therapy groups and placebo","expected_outcomes":"The study hypothesized that imaging biomarkers would reveal early detection of evolving brain pathology if hormone therapy had long-term effects on AD risk","statistical_methods":"Statistical comparisons between treatment groups, analysis of APOE ε4 modifying effects"},"created_at":"2026-04-11T00:48:06-07:00","updated_at":"2026-04-11T00:48:06-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-11T00:48:06-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"dad92923-b495-4033-b69c-d6fe4fe3d4ff","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"notebook-pathway_2026_04_02","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'apoe'"},{"target_artifact_id":"notebook-SEA-AD-gene-expression-analysis","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'apoe'"},{"target_artifact_id":"wiki-biomarkers-alzheimers-biomarkers","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Alzheimer's Disease Biomarkers"},{"target_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-technologies-magnetic-resonance-imaging","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MRI"},{"target_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-cell-types-apoe-expressing-astrocytes","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-events-aaic-2026-biomarker-integration-pet-fluid-combination","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PET"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimer's-disease-regulat","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diagnostics-mri-findings-in-corticobasal-syndrome","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MRI"},{"target_artifact_id":"wiki-genes-apoe","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diagnostics-neuroimaging","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: neuroimaging"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diagnostics-apoe-genotyping","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-biomarkers","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Biomarkers"},{"target_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-proteins-apoe","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-cell-types-lateral-prefrontal-cortex","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Lateral Prefrontal Cortex"},{"target_artifact_id":"wiki-cell-types-dorsolateral-prefrontal-cortex","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Dorsolateral Prefrontal Cortex"},{"target_artifact_id":"wiki-researchers","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Researchers"},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-psen1-mutations","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-technologies-pet-imaging","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PET"},{"target_artifact_id":"wiki-therapeutics-apoe-genotype-guided-prevention","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"target_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-biomarkers-mri-atrophy-cbs-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: MRI"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: alzheimer's disease"},{"target_artifact_id":"wiki-diagnostics-pet-imaging","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PET"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"mentions","strength":0.9,"evidence":"target_gene: APOE"}],"incoming_links":[{"source_artifact_id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"experiment-exp-a6d16514-1a7a-45c3-8ca8-df341e213c0a","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"experiment-exp-2267dce9-5cf9-4e2f-a543-e339e9156522","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'apoe'"},{"source_artifact_id":"notebook-pathway_2026_04_02","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'apoe'"},{"source_artifact_id":"notebook-SEA-AD-gene-expression-analysis","link_type":"related","strength":0.6,"evidence":"Both artifacts share KG entity: 'apoe'"},{"source_artifact_id":"wiki-biomarkers-alzheimers-biomarkers","link_type":"mentions","strength":0.6,"evidence":"Title match: Alzheimer's Disease Biomarkers"},{"source_artifact_id":"wiki-diseases-preclinical-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-technologies-magnetic-resonance-imaging","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MRI"},{"source_artifact_id":"wiki-diseases-alzheimers-parkinsons-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-cell-types-apoe-expressing-astrocytes","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-events-aaic-2026-biomarker-integration-pet-fluid-combination","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PET"},{"source_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimer's-disease-regulat","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-early-onset-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-dementia-lewy-bodies-parkinsons-alzheimers-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-psen2-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diagnostics-mri-findings-in-corticobasal-syndrome","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MRI"},{"source_artifact_id":"wiki-genes-apoe","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diagnostics-neuroimaging","link_type":"mentions","strength":0.6,"evidence":"Title match: neuroimaging"},{"source_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diagnostics-apoe-genotyping","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-trem2-variants-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-biomarkers","link_type":"mentions","strength":0.6,"evidence":"Title match: Biomarkers"},{"source_artifact_id":"wiki-diseases-app-mutations-in-ad","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-agitation-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-proteins-apoe","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-cell-types-lateral-prefrontal-cortex","link_type":"mentions","strength":0.6,"evidence":"Title match: Lateral Prefrontal Cortex"},{"source_artifact_id":"wiki-cell-types-dorsolateral-prefrontal-cortex","link_type":"mentions","strength":0.6,"evidence":"Title match: Dorsolateral Prefrontal Cortex"},{"source_artifact_id":"wiki-researchers","link_type":"mentions","strength":0.6,"evidence":"Title match: Researchers"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-psen1-mutations","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-alzheimers-genetic-variants","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-sporadic-familial-ad-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-technologies-pet-imaging","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PET"},{"source_artifact_id":"wiki-therapeutics-apoe-genotype-guided-prevention","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"source_artifact_id":"wiki-diseases-investment-landscape-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diseases-prodromal-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-biomarkers-mri-atrophy-cbs-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: MRI"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Disease match: alzheimer's disease"},{"source_artifact_id":"wiki-diagnostics-pet-imaging","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PET"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.6,"evidence":"Disease match: Alzheimer's disease"},{"source_artifact_id":"open_question-6ef95175-77b3-467b-b2a1-06df5bb024ef","link_type":"partial_answer_for","strength":0.68,"evidence":"{\"confidence\": 0.68, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-cae3f33d-c521-41eb-a129-de88719231be","link_type":"partial_answer_for","strength":0.72,"evidence":"{\"confidence\": 0.72, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-46fe4d77-2fcd-422e-9a61-7b7531e8204c","link_type":"discriminating_experiment","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-bb917df2-99a1-4b3e-a0a7-c24cad8233d7","link_type":"bears_on_question","strength":0.62,"evidence":"{\"confidence\": 0.62, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-642754e6-5f66-4f8a-a2c6-efaa408bca05","link_type":"bears_on_question","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","is_canonical":true,"supersede_chain":["experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1"]}