{"artifact":{"id":"experiment-exp-d081efb0-0d00-49ff-80b2-4865e90992e1","artifact_type":"experiment","entity_ids":"[\"CGAS\"]","title":"cGAS/STING pathway activation by TDP-43-released mtDNA","quality_score":0.95,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"f7ee4ff6f340bc690795e909cc83221ffe9b85aad7ada12b30f96251802dd77b","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-06T12:28:36.731202"},"p_value":null,"protocol":"Pharmacologic inhibition and genetic deletion of cGAS and STING, measurement of downstream inflammatory signaling including NF-κB and type I IFN pathways","effect_size":null,"sample_size":null,"source_pmid":"33031745","extracted_at":"2026-04-06T05:28:36.707804","_schema_version":1,"experiment_type":"cell_biology","success_criteria":"Reduced NF-κB and type I IFN activation upon cGAS/STING inhibition","expected_outcomes":"cGAS/STING inhibition prevents TDP-43-induced inflammatory signaling","statistical_methods":null},"created_at":"2026-04-06T12:28:36-07:00","updated_at":"2026-04-06T12:28:36-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-06T12:28:36-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ebf45a44-efd6-4cc6-b749-65b94e33a041","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-cell-types-dna-damage-repair-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-therapeutics-dna-repair-therapy-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-molecular-subtypes","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-biomarkers-dna-methylation-biomarkers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-experiments-als-regional-onset-spread","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-dna-methylation-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-trial-failure-analysis","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-ideas-dna-damage-repair-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-biomarkers-and-disease-monitoring","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-als-cure-roadmap","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-proteins-tdp-43-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-datasets-amp-pd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: AMP"},{"target_artifact_id":"wiki-cell-types-amyotrophic-lateral-sclerosis-frontotemporal-dementia-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-biomarkers-tdp-43","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-entities-dna-methylation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-gaps-als-motor-neuron-vulnerability","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-spinal-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-therapeutics-als-therapeutics","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-technologies-als-communication-bci","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-cell-types-tdp-43-aggregate-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-prkdc-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-therapeutics-als-therapeutic-landscape","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-therapeutic-scorecard","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-cell-types-ftd-tdp-43-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-therapeutics-dna-damage-repair-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-4r-tauopathies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-diseases-als-genetic-variants","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-mechanisms-als-ftd-unified-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-als-knowledge-gaps-ranked","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-therapeutics-als-treatment-strategies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-fus-mutations-als","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-therapeutics-als-treatment","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-cell-types-dna-damage-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-als-tdp43-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-dna-damage-repair-disease-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-diseases-als-ftd-parkinsonism-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-sod1-mutations-als","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-proteins-tdp43_protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-companies-als-pipeline-companies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-dna-damage-repair","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-cell-types-tdp43-proteinopathy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-experiments","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Experiments"},{"target_artifact_id":"wiki-mechanisms-als-progression-trajectories","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-dna-repair-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-cell-types-tdp-43-proteinopathy-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-reversibility-als","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-gaps-tdp-43-pet-ligand-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-sting-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: STING"},{"target_artifact_id":"wiki-mechanisms-als-combination-therapy-matrix","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-als","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-mechanisms-als-biomarker-mechanism-map","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-institutions-als-association","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-sting-casm-gabarap-lrrk2-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: STING"},{"target_artifact_id":"wiki-investment-als-vs-ftd-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-gaps-als-progression-rate-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-als-failed-approaches-analysis","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-neuroinflammation","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: neuroinflammation"},{"target_artifact_id":"wiki-mechanisms-als-ftd-overlap","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-experiments-als-progression-rate-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-proteins-lig3-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-experiments-tdp43-tau-pathology-determination-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-gaps-als-regional-onset-spread","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-als-ftd-spectrum","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-proteins-tar-db-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-sting1-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: STING"},{"target_artifact_id":"wiki-mechanisms-tdp43-dna-repair-als-dementia","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-diseases-bulbar-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-investment-tdp-43-proteinopathy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-therapeutics-sting-inhibitor-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: STING"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-dna-damage-ad-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-gaps-als-immune-signature-stratification","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-genes-cgas","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: CGAS"},{"target_artifact_id":"wiki-genes-sting","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: STING"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-experiments-dna-damage-repair-deficiency-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-gaps-als-trial-failures","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-ideas-payload-tdp43-splicing-modulation-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-psp-dna-damage-repair-dysfunction","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-investment-dna-damage-repair","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-hypotheses-dna-damage-repair-deficiency-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-institutions-als-clinical-trials-consortium","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-diseases-tdp-43-pathology-corticobasal-syndrome","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp43-rna-granule-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-companies-als-pipeline","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-dna-sensing-pathways-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-gaps-als","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-proteins-lig4-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-entities-mitochondria","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Mitochondria"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-tdp-43-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-als-tdp43-pathology","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-dna-damage-response-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-mechanisms-tdp-43-cortico-basal-syndrome","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-als-rna-metabolism-and-proteostasis-failure","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-tdp-43-fus-rna-proteinopathy-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-diseases-tardbp-mutations-als","link_type":"related","strength":0.54,"evidence":"Reverse: Disease match: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-diseases-als-progression-rate-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-proteins-tdp43-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-therapeutics-als-cure-roadmap","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ALS"},{"target_artifact_id":"wiki-mechanisms-tdp-43-proteinopathy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-dna-damage-response","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: DNA"},{"target_artifact_id":"wiki-hypotheses-cgas-sting-parkinsons","link_type":"mentions","strength":0.9,"evidence":"target_gene: CGAS"},{"target_artifact_id":"wiki-diseases-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.7,"evidence":"disease: amyotrophic lateral sclerosis"},{"target_artifact_id":"wiki-genes-sting","link_type":"mentions","strength":0.5,"evidence":"Entity STING in experiment"},{"target_artifact_id":"paper-33031745","link_type":"derives_from","strength":1.0,"evidence":"Extracted from paper abstract/full text"}],"incoming_links":[{"source_artifact_id":"wiki-diseases-als-genetic-variants","link_type":"related","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-cell-types-hek293","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CGAS mentioned 2x in wiki/cell-types-hek293"},{"source_artifact_id":"wiki-cell-types-glial-cells","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CGAS mentioned 2x in wiki/cell-types-glial-cells"},{"source_artifact_id":"wiki-cell-types-enteroendocrine-cells","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CGAS mentioned 2x in wiki/cell-types-enteroendocrine-cells"},{"source_artifact_id":"wiki-mechanisms-interferon-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: CGAS mentioned 4x in wiki/mechanisms-interferon-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-neuroinflammation-mitochondria-crosstalk","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CGAS mentioned 2x in wiki/mechanisms-neuroinflammation-mitochondria-crosstalk"},{"source_artifact_id":"wiki-entities-tumor-necrosis-factor","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CGAS mentioned 2x in wiki/entities-tumor-necrosis-factor"},{"source_artifact_id":"wiki-hypotheses-cgas-sting-parkinsons","link_type":"mentions","strength":0.9,"evidence":"target_gene: CGAS"},{"source_artifact_id":"wiki-diseases-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.7,"evidence":"disease: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-mechanisms-dna-methylation-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-trial-failure-analysis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-ideas-dna-damage-repair-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-biomarkers-and-disease-monitoring","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-als-cure-roadmap","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-proteins-tdp-43-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-datasets-amp-pd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: AMP"},{"source_artifact_id":"wiki-cell-types-amyotrophic-lateral-sclerosis-frontotemporal-dementia-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-biomarkers-tdp-43","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-entities-dna-methylation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-gaps-als-motor-neuron-vulnerability","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-spinal-amyotrophic-lateral-sclerosis","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-therapeutics-als-therapeutics","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-technologies-als-communication-bci","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-cell-types-tdp-43-aggregate-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-prkdc-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-therapeutics-als-therapeutic-landscape","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-therapeutic-scorecard","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-cell-types-ftd-tdp-43-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-therapeutics-dna-damage-repair-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-4r-tauopathies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-diseases-als-genetic-variants","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-mechanisms-als-ftd-unified-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-als-knowledge-gaps-ranked","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-therapeutics-als-treatment-strategies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-fus-mutations-als","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-therapeutics-als-treatment","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-cell-types-dna-damage-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-tdp43-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-dna-damage-repair-disease-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-diseases-als-ftd-parkinsonism-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-sod1-mutations-als","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-proteins-tdp43_protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-companies-als-pipeline-companies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-dna-damage-repair","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-cell-types-tdp43-proteinopathy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-experiments","link_type":"mentions","strength":0.6,"evidence":"Title match: Experiments"},{"source_artifact_id":"wiki-mechanisms-als-progression-trajectories","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-dna-repair-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-cell-types-tdp-43-proteinopathy-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp-43-reversibility-als","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-gaps-tdp-43-pet-ligand-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-sting-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: STING"},{"source_artifact_id":"wiki-mechanisms-als-combination-therapy-matrix","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-als","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-mechanisms-als-biomarker-mechanism-map","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-institutions-als-association","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-sting-casm-gabarap-lrrk2-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: STING"},{"source_artifact_id":"wiki-investment-als-vs-ftd-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-gaps-als-progression-rate-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-als-failed-approaches-analysis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-neuroinflammation","link_type":"mentions","strength":0.6,"evidence":"Title match: neuroinflammation"},{"source_artifact_id":"wiki-mechanisms-als-ftd-overlap","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-experiments-als-progression-rate-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-proteins-lig3-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-experiments-tdp43-tau-pathology-determination-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-gaps-als-regional-onset-spread","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-als-ftd-spectrum","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-proteins-tar-db-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-sting1-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: STING"},{"source_artifact_id":"wiki-mechanisms-tdp43-dna-repair-als-dementia","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-bulbar-amyotrophic-lateral-sclerosis","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-experiments-tdp43-pet-ligand-development","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-investment-tdp-43-proteinopathy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-therapeutics-sting-inhibitor-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: STING"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-dna-damage-ad-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-gaps-als-immune-signature-stratification","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-genes-cgas","link_type":"mentions","strength":0.8,"evidence":"Gene target: CGAS"},{"source_artifact_id":"wiki-genes-sting","link_type":"mentions","strength":0.7,"evidence":"Gene mention: STING"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-experiments-dna-damage-repair-deficiency-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-gaps-als-trial-failures","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-ideas-payload-tdp43-splicing-modulation-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-psp-dna-damage-repair-dysfunction","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-investment-dna-damage-repair","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-hypotheses-dna-damage-repair-deficiency-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-institutions-als-clinical-trials-consortium","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-diseases-tdp-43-pathology-corticobasal-syndrome","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp43-rna-granule-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-companies-als-pipeline","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-dna-sensing-pathways-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-gaps-als","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-proteins-lig4-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-entities-mitochondria","link_type":"mentions","strength":0.6,"evidence":"Title match: Mitochondria"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-tdp-43-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-als-tdp43-pathology","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-dna-damage-response-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-tdp-43-cortico-basal-syndrome","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-als-rna-metabolism-and-proteostasis-failure","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-tdp-43-fus-rna-proteinopathy-comparison","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-tardbp-mutations-als","link_type":"mentions","strength":0.6,"evidence":"Disease match: amyotrophic lateral sclerosis"},{"source_artifact_id":"wiki-diseases-als-progression-rate-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-proteins-tdp43-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-therapeutics-als-cure-roadmap","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-mechanisms-tdp-43-proteinopathy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-cell-types-dna-damage-repair-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-therapeutics-dna-repair-therapy-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-mechanisms-als-molecular-subtypes","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"},{"source_artifact_id":"wiki-biomarkers-dna-methylation-biomarkers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: DNA"},{"source_artifact_id":"wiki-experiments-als-regional-onset-spread","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ALS"}],"current_artifact_id":"experiment-exp-d081efb0-0d00-49ff-80b2-4865e90992e1","is_canonical":true,"supersede_chain":["experiment-exp-d081efb0-0d00-49ff-80b2-4865e90992e1"]}