{"artifact":{"id":"experiment-exp-dbfdb26b-4a5f-463a-8a23-9e7dbdbe0d1a","artifact_type":"experiment","entity_ids":"[\"SNCA\"]","title":"PFF uptake in primary hippocampal neurons with inhibitors","quality_score":0.9,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"236dec9607d3db16635529f5bf7ed2040d36e0e4a2aa06f86830041bda2c5ad0","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-11T00:48:31.411165"},"p_value":null,"protocol":"PFFs labeled with pH-sensitive dye were applied to cultured neurons, with treatment using dynamin or clathrin inhibitors","effect_size":null,"sample_size":null,"source_pmid":"41508763","extracted_at":"2026-04-10T17:48:31.406278","_schema_version":1,"experiment_type":"cell_biology","success_criteria":"significant reduction in PFF uptake with dynamin inhibition","expected_outcomes":"PFF uptake would be blocked by dynamin inhibitors but not clathrin inhibitors","statistical_methods":null},"created_at":"2026-04-11T00:48:31-07:00","updated_at":"2026-04-11T00:48:31-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-11T00:48:31-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"2993d93f-528f-48c8-9d43-5e38d68e4303","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-e67da95a-fc6f-457a-9743-1cc6ea90e57f","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"experiment-exp-28e744bb-a65b-4b06-8636-82e5a2986207","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"target_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-lewy-bodies-causal-chain","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-diseases-snca-variants","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-diseases-snca-a53t","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-cell-types-snca-a53t-neurons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-proteins-snca-protein","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-pd-causal-chain","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Mechanisms"},{"target_artifact_id":"wiki-cell-types-snca-overexpressing-dopaminergic-neurons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-genes-snca","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-cell-types-hippocampal-neurons","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Hippocampal Neurons"},{"target_artifact_id":"wiki-entities-snca","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: SNCA"},{"target_artifact_id":"wiki-mechanisms-nct04724941-prodromal-alpha-synuclein-screening","link_type":"mentions","strength":0.9,"evidence":"target_gene: SNCA"}],"incoming_links":[{"source_artifact_id":"experiment-exp-e67da95a-fc6f-457a-9743-1cc6ea90e57f","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-28e744bb-a65b-4b06-8636-82e5a2986207","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-lewy-bodies-causal-chain","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-diseases-snca-variants","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-diseases-snca-a53t","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-cell-types-snca-a53t-neurons","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-proteins-snca-protein","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-pd-causal-chain","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-cell-types-snca-overexpressing-dopaminergic-neurons","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-genes-snca","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-cell-types-hippocampal-neurons","link_type":"mentions","strength":0.6,"evidence":"Title match: Hippocampal Neurons"},{"source_artifact_id":"wiki-entities-snca","link_type":"mentions","strength":0.8,"evidence":"Gene target: SNCA"},{"source_artifact_id":"wiki-mechanisms-nct04724941-prodromal-alpha-synuclein-screening","link_type":"mentions","strength":0.9,"evidence":"target_gene: SNCA"},{"source_artifact_id":"open_question-6a9df73d-c9ce-4987-ba6a-7ad5aae43d64","link_type":"partial_answer_for","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"experiment-exp-dbfdb26b-4a5f-463a-8a23-9e7dbdbe0d1a","is_canonical":true,"supersede_chain":["experiment-exp-dbfdb26b-4a5f-463a-8a23-9e7dbdbe0d1a"]}