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control vectors at matching titer\n• Validate vector integrity and infectivity in primary astrocyte cultures\n• Confirm astrocyte-specific expression using GFAP co-staining\n\n**Phase 3: Stereotactic Injection (Week 4)**\n• Anesthetize mice with isoflurane (2-3%)\n• Perform bilateral hippocampal injections (coordinates: AP -2.0mm, ML ±1.5mm, DV -1.5mm)\n• Inject 2μL of viral vector per site at 0.5μL/min rate\n• Allow 3-week recovery period for optimal transgene expression\n\n**Phase 4: Neuroi","replication_status":"single_study","extraction_metadata":{"backfill_at":"2026-04-16T01:00:16.908698","needs_review":true,"extraction_notes":"Backfilled from debate_extraction source (no PMID 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