{"artifact":{"id":"experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994","artifact_type":"experiment","entity_ids":"[\"Cdk5, p35, p39\"]","title":"Mouse Cdk5, p35, and p39 mutations in neuronal migration","quality_score":0.8,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"6b709d9e2ac1f693e5ae057cd8ac4786c3e0b794255eb9c5a21671a51c3610fd","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-06T12:34:08.534940"},"p_value":null,"protocol":"generation and phenotypic analysis of mice with mutations in Cdk5, p35, or p39","effect_size":null,"sample_size":null,"source_pmid":"11429281","extracted_at":"2026-04-06T05:34:08.473598","_schema_version":1,"experiment_type":"animal_model","success_criteria":"demonstration of migration phenotype consistent with defective nucleokinesis","expected_outcomes":"mutations would cause defective nucleokinesis and potentially leading edge formation 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mentioned 2x in wiki/mechanisms-systemic-infection-tau-pathology"},{"source_artifact_id":"wiki-mechanisms-traumatic-brain-injury-neurodegeneration-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-traumatic-brain-injury-neurodegeneration-pathway"},{"source_artifact_id":"wiki-mechanisms-tau-kinase-phosphatase-balance","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 19x in wiki/mechanisms-tau-kinase-phosphatase-balance"},{"source_artifact_id":"wiki-mechanisms-viral-post-infectious-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-viral-post-infectious-als"},{"source_artifact_id":"wiki-mechanisms-3r-tauopathy","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 4x in 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wiki/mechanisms-calcium-dysregulation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-psp-epigenetic-changes","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-psp-epigenetic-changes"},{"source_artifact_id":"wiki-mechanisms-cdk-5","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 86x in wiki/mechanisms-cdk-5"},{"source_artifact_id":"wiki-mechanisms-innate-immune-signaling-ad","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-innate-immune-signaling-ad"},{"source_artifact_id":"wiki-mechanisms-mixed-tauopathy","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-mixed-tauopathy"},{"source_artifact_id":"wiki-mechanisms-dyrk1a-tau-phosphorylation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 11x in wiki/mechanisms-dyrk1a-tau-phosphorylation-pathway"},{"source_artifact_id":"wiki-mechanisms-cbs-tau-phosphorylation","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 13x in wiki/mechanisms-cbs-tau-phosphorylation"},{"source_artifact_id":"wiki-mechanisms-tau-phosphorylation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 7x in wiki/mechanisms-tau-phosphorylation-pathway"},{"source_artifact_id":"wiki-mechanisms-gsk3beta-tau-phosphorylation-complex","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 9x in wiki/mechanisms-gsk3beta-tau-phosphorylation-complex"},{"source_artifact_id":"wiki-mechanisms-alzheimers-pathogenesis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-alzheimers-pathogenesis"},{"source_artifact_id":"wiki-mechanisms-kynurenine-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-kynurenine-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-nucleocytoplasmic-transport-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-nucleocytoplasmic-transport-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-tauopathy","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-tauopathy"},{"source_artifact_id":"wiki-mechanisms-amyloid-cascade-hypothesis","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-amyloid-cascade-hypothesis"},{"source_artifact_id":"wiki-mechanisms-mark-tau-phosphorylation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 4x in wiki/mechanisms-mark-tau-phosphorylation-pathway"},{"source_artifact_id":"wiki-mechanisms-kinase-targeting-neurodegenerative-diseases","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 15x in wiki/mechanisms-kinase-targeting-neurodegenerative-diseases"},{"source_artifact_id":"wiki-mechanisms-glucocorticoid-signaling-pathway","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-glucocorticoid-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-app-amyloid-beta-plaque-ad-causal-chain","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-app-amyloid-beta-plaque-ad-causal-chain"},{"source_artifact_id":"wiki-mechanisms-notch-signaling-4r-tauopathies","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-notch-signaling-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-epigenetics-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-epigenetics-als"},{"source_artifact_id":"wiki-mechanisms-phosphoproteomics-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-phosphoproteomics-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-iron-accumulation-psp","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-iron-accumulation-psp"},{"source_artifact_id":"wiki-mechanisms-tau-ptm-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-tau-ptm-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-small-molecule-derivatives-neurodegenerative-pathways","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-small-molecule-derivatives-neurodegenerative-pathways"},{"source_artifact_id":"wiki-mechanisms-pp2a-tau-phosphatase-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-pp2a-tau-phosphatase-pathway"},{"source_artifact_id":"wiki-mechanisms-tau-propagation","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 4x in wiki/mechanisms-tau-propagation"},{"source_artifact_id":"wiki-mechanisms-gsk3-beta-signaling","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 5x in wiki/mechanisms-gsk3-beta-signaling"},{"source_artifact_id":"wiki-mechanisms-pdgf-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-pdgf-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-gsk3-parkinsons-disease","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-gsk3-parkinsons-disease"},{"source_artifact_id":"wiki-mechanisms-jak-stat-cytokine-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/mechanisms-jak-stat-cytokine-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-yin-yang-hypothesis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-yin-yang-hypothesis"},{"source_artifact_id":"wiki-mechanisms-psp-spatial-transcriptomics","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-psp-spatial-transcriptomics"},{"source_artifact_id":"wiki-mechanisms-ftd-tau-subtypes-comparison","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-ftd-tau-subtypes-comparison"},{"source_artifact_id":"wiki-mechanisms-alzheimers-neuroinflammation","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-alzheimers-neuroinflammation"},{"source_artifact_id":"wiki-biomarkers-csf-pta217","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/biomarkers-csf-pta217"},{"source_artifact_id":"wiki-biomarkers-p-tau-181","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/biomarkers-p-tau-181"},{"source_artifact_id":"wiki-biomarkers-p-tau-231","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/biomarkers-p-tau-231"},{"source_artifact_id":"wiki-biomarkers-p-tau181","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/biomarkers-p-tau181"},{"source_artifact_id":"wiki-entities-ryanodine-receptor","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/entities-ryanodine-receptor"},{"source_artifact_id":"wiki-entities-calpains","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 7x in wiki/entities-calpains"},{"source_artifact_id":"wiki-entities-overview","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/entities-overview"},{"source_artifact_id":"wiki-experiments-microbiome-gut-barrier-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/experiments-microbiome-gut-barrier-als"},{"source_artifact_id":"wiki-experiments-sleep-respiratory-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/experiments-sleep-respiratory-als"},{"source_artifact_id":"wiki-experiments-environmental-exposure-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/experiments-environmental-exposure-als"},{"source_artifact_id":"wiki-diseases-als","link_type":"mentions","strength":0.5,"evidence":"Content: CDK5 mentioned 3x in wiki/diseases-als"},{"source_artifact_id":"wiki-cell-types-tau-pathology-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/cell-types-tau-pathology-neurons"},{"source_artifact_id":"wiki-cell-types-argyrophilic-grain-disease-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/cell-types-argyrophilic-grain-disease-neurons"},{"source_artifact_id":"wiki-proteins-q00535","link_type":"mentions","strength":0.8,"evidence":"Gene target: CDK5"},{"source_artifact_id":"wiki-proteins-cdk5r1-protein","link_type":"mentions","strength":0.8,"evidence":"Gene target: P35"},{"source_artifact_id":"wiki-genes-cdk5","link_type":"mentions","strength":0.8,"evidence":"Gene target: CDK5"},{"source_artifact_id":"wiki-proteins-cdk5-protein","link_type":"mentions","strength":0.8,"evidence":"Gene target: CDK5"},{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-proteins-cdk5","link_type":"mentions","strength":0.8,"evidence":"Gene target: CDK5"},{"source_artifact_id":"wiki-therapeutics-cdk5-inhibitors-neurodegeneration","link_type":"mentions","strength":0.8,"evidence":"Gene target: CDK5"},{"source_artifact_id":"wiki-mechanisms-neuronal-migration","link_type":"mentions","strength":0.6,"evidence":"Title match: Neuronal Migration"},{"source_artifact_id":"open_question-d404f502-9c2b-4e0a-bd69-582c4f00f31b","link_type":"bears_on_question","strength":0.42,"evidence":"{\"confidence\": 0.42, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-98b3e538-39c3-45df-9d8f-e5918d3801ca","link_type":"partial_answer_for","strength":0.75,"evidence":"{\"confidence\": 0.75, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994","is_canonical":true,"supersede_chain":["experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994"]}