{"artifact":{"id":"hypothesis-h-3156f6bcd349","artifact_type":"hypothesis","entity_ids":"[]","title":"GPX4 reserve failure gates selective ALS motor-neuron ferroptosis","quality_score":0.745,"created_by":"hypothesis_page_handler","provenance_chain":"[]","content_hash":"3f50d2f072ed1861c650b9c44668516a67c4d170ebc81d84d0ea005ff2a41688","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T14:43:01.422985"},"description":"ALS-linked proteostasis stress lowers effective GPX4 reserve in vulnerable motor neurons, allowing oxidized phospholipids to cross a ferroptotic death threshold. Restoring GPX4 activity or glutathione availability should rescue motor-neuron survival more strongly than generic antioxidants.","hypothesis_id":"h-3156f6bcd349","_schema_version":1},"created_at":"2026-04-28T07:43:01.423088-07:00","updated_at":"2026-04-28T07:43:01.423088-07:00","version_number":3,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"8cba757f-2491-44f5-9d76-885a8a01e5df","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"hypothesis_page_handler"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[{"source_artifact_id":"bench_als_motor_neuron_survival_genes_v1","link_type":"related","strength":0.75,"evidence":"ALS Motor Neuron Survival Gene Prediction benchmark seeded to evaluate hypotheses/gaps related to hypothesis-h-3156f6bcd349 (forge:benchmark_seed_2026-04-28)."}],"current_artifact_id":"hypothesis-h-3156f6bcd349","is_canonical":true,"supersede_chain":["hypothesis-h-3156f6bcd349"]}