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signaling"},{"target_artifact_id":"wiki-mechanisms-hippo-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ghrelin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-camkii-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-mapk-jak-stat-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-camp-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-fbxo7-mitophagy-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-rab39b-endosomal-lysosomal-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-vip-vasoactive-intestinal-peptide-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-short-chain-fatty-acids","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gp130-il6-family-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-lrrk2-pathway-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-calcium-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cd33-siglec-receptor-dysfunction-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tam-receptor-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-interferon-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-endothelin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-interleukin-6-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ppar-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-s1p-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-lrp1-apoe-signaling-cascade","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pd1-pdl1-immune-checkpoint-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tnap-p2x7-ctcf-axis-tauopathy","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-rage-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pyroptosis-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-factor-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-notch-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hedgehog-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-abca1-cholesterol-efflux-apoe-lipidation-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-trem2-cytokine-regulation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-fgf-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tgf-beta-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-notch-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-citric-acid-cycle","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cgmp-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hif-hypoxia-signaling-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-synj1-synaptojanin-1-synaptic-vesicle-recycling-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nf-kb-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-slit-robo-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-yap-taz-hippo-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-trem2-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nrf2-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-notch-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gdnf-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neuropeptide-gpcr-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-leptin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cntf-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-endocannabinoid-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-androgen-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-fgf-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hippo-signaling-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-focal-adhesion-kinase-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-adiponectin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-omega-3-fatty-acid-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-erythropoietin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-retinoic-acid-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hedgehog-signaling-cbs-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-psen1-presenilin-1-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-chchd10-mitochondrial-dysfunction-als-ftd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cr1-complement-synaptic-pruning-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-histamine-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-innate-immune-signaling-ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-melatonin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-semaphorin-plexin-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-adenosine-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tgf-beta-bmp-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-toll-like-receptor-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-orexin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-foxo-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nf-kappa-b-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-lxr-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-mtor-dysregulation-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-jak-stat-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hedgehog-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-integrin-signaling-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-p75ntr-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-serotonin-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-p70s6k-mtorc1-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-somatostatin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ephrin-ephr-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-peroxisome-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-calcium-dysregulation-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-microglia-corticobasal-degeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-c9orf72-rna-foci-dipeptide-repeats-als-ftd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-bdnf-neurotrophin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nrf2-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ceramide-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pten-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-vegfr-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hydrogen-sulfide-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tlr-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-chemokine-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-integrin-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-connexin-hemichannel-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-beta-catenin-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-egfr-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-atp13a2-lysosomal-dysfunction-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cholinergic-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-vps35-retromer-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ampk-signaling-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-microglia-ftd-progression","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-calcineurin-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-jnk-p38-mapk-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-anti-amyloid-therapeutics","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gpcr-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-signaling-disease-comparison","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tgf-beta-signaling-cbs-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gdnf-neurotrophic-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tgf-beta-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-vitamin-d-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-jak-stat-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-snca-alpha-synuclein-lewy-bodies-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-uchl1-ubiquitin-proteasome-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hippo-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-serotonin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nfkb-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-lrrk2-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-camp-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sod1-superoxide-dismutase-als-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-inpp5d-ship1-dysfunction-neuroinflammation-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sorl1-app-trafficking-retromer-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-brain-insulin-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-metabolic-dysfunction-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gdnf-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-fus-als-ftd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-optn-mitophagy-neurodegeneration-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ephrin-ephr-receptor-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-bin1-endosomal-dysfunction-tau-pathology-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nt-3-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pi3k-akt-mtor-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-mapk-erk-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-netrin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-notch-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gaba-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-glucocorticoid-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-estrogen-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nad-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurovascular-unit-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sestrin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-insulin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-picalm-clathrin-endocytosis-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ptk2b-pyk2-synaptic-dysfunction-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-growth-factor-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cxcl12-cxcr4-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nt-4-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-thyroid-hormone-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-yap-taz-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tnf-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-app-amyloid-beta-plaque-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-natriuretic-peptide-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-factor-decline","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gabaergic-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-fibroblast-growth-factor-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-notch-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-akt-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neuropeptide-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-park7-dj1-neuroprotection-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-grn-progranulin-ftd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-pannexin-p2x7-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gba1-gcase-lysosome-pd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-quinolinic-acid-neurotoxicity","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-clu-clusterin-amyloid-clearance-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-cgas-sting-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-insulin-signaling-pathway-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-psen2-presenilin-2-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gabaergic-dysfunction-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-il-6-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-testosterone-neurodegeneration-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gdf-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-microglia-neuroinflammation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gsk3-beta-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-microglia-activation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurotrophin-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-protein-kinase-c-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-phospholipase-signaling-cbs-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-mtor-signaling-cbs-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-calcium-signaling-ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-ampk-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-nfkb-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-hif-hypoxia-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-neurotrophin-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-jnk-p38-mapk-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sigma1-receptor-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-substance-p-nk1-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-dopamine-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-mtor-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sphingolipid-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-integrin-signaling-cbs-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-gsk3-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-sirt1-alzheimer-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-tyrobp-dap12-microglia-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-wnt-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-dctn1-dynactin-perry-syndrome-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"wiki-mechanisms-jak-stat-cytokine-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-ephrin-ephr-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-peroxisome-signaling-pathway-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-calcium-dysregulation-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-microglia-corticobasal-degeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-ampk-signaling-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-microglia-ftd-progression","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-calcineurin-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-jnk-p38-mapk-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-neurotrophic-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-inpp5d-ship1-dysfunction-neuroinflammation-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-sorl1-app-trafficking-retromer-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-brain-insulin-signaling","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-metabolic-dysfunction-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-gdnf-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-fus-als-ftd-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-optn-mitophagy-neurodegeneration-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-ephrin-ephr-receptor-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-bin1-endosomal-dysfunction-tau-pathology-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-nt-3-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-pi3k-akt-mtor-signaling-pathway-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-mapk-erk-signaling-pathway-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-netrin-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-notch-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-neurovascular-unit-signaling","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-sestrin-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-insulin-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-picalm-clathrin-endocytosis-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-ptk2b-pyk2-synaptic-dysfunction-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-growth-factor-signaling-4r-tauopathies","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-cxcl12-cxcr4-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-wnt-signaling-pathway-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-tnf-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-app-amyloid-beta-plaque-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-natriuretic-peptide-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-neurotrophic-factor-decline","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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signaling"},{"source_artifact_id":"wiki-mechanisms-cgas-sting-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-insulin-signaling-pathway-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-psen2-presenilin-2-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-gabaergic-dysfunction-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-il-6-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-testosterone-neurodegeneration-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-gdf-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"wiki-mechanisms-microglia-neuroinflammation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory 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