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Title match: Clinical Trials"},{"target_artifact_id":"wiki-cell-types-blood-brain-barrier","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Blood-Brain Barrier"},{"target_artifact_id":"wiki-therapeutics-levodopa","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: levodopa"},{"target_artifact_id":"wiki-diseases-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Parkinson's Disease"},{"target_artifact_id":"wiki-diseases-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Amyotrophic Lateral Sclerosis"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Alzheimer's Disease"},{"target_artifact_id":"wiki-investment","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Investment"},{"target_artifact_id":"wiki-institutions-biogen","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Biogen"},{"target_artifact_id":"wiki-companies-passage-bio","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Passage Bio"},{"target_artifact_id":"wiki-diseases-huntingtons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Huntington's Disease"},{"target_artifact_id":"wiki-biomarkers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Biomarkers"},{"target_artifact_id":"wiki-entities-lecanemab","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: lecanemab"},{"target_artifact_id":"wiki-diagnostics-neuroimaging","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: neuroimaging"},{"target_artifact_id":"wiki-proteins-alpha-synuclein","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: alpha-synuclein"},{"target_artifact_id":"wiki-companies-biogen","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Biogen"},{"target_artifact_id":"wiki-therapeutics","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Therapeutics"},{"target_artifact_id":"wiki-entities","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/entities"},{"target_artifact_id":"wiki-ideas","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/ideas"},{"target_artifact_id":"wiki-therapeutics-melatonin-therapy-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/therapeutics-melatonin-therapy-neurodegeneration"},{"target_artifact_id":"wiki-therapeutics-dna-damage-repair-therapy","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-dna-damage-repair-therapy"},{"target_artifact_id":"wiki-therapeutics-section-248-epigenetic-clock-reversal-cbs-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-section-248-epigenetic-clock-reversal-cbs-psp"},{"target_artifact_id":"wiki-therapeutics-section-162-advanced-antioxidant-redox-therapy-cbs-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/therapeutics-section-162-advanced-antioxidant-redox-therapy-cbs-psp"},{"target_artifact_id":"wiki-therapeutics-personalized-treatment-plan-atypical-parkinsonism","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 7x in wiki/therapeutics-personalized-treatment-plan-atypical-parkinsonism"},{"target_artifact_id":"wiki-therapeutics-section-148-advanced-nutritional-biochemistry-cbs-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 7x in wiki/therapeutics-section-148-advanced-nutritional-biochemistry-cbs-psp"},{"target_artifact_id":"wiki-therapeutics-sirtuin-modulators","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 23x in wiki/therapeutics-sirtuin-modulators"},{"target_artifact_id":"wiki-therapeutics-melatonin-therapy-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-melatonin-therapy-parkinsons"},{"target_artifact_id":"wiki-therapeutics-metformin-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-metformin-neurodegeneration"},{"target_artifact_id":"wiki-therapeutics-sirtuin-modulators-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 42x in wiki/therapeutics-sirtuin-modulators-parkinsons"},{"target_artifact_id":"wiki-therapeutics-hdac-inhibitors-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-hdac-inhibitors-neurodegeneration"},{"target_artifact_id":"wiki-therapeutics-nicotinamide-riboside","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 19x in wiki/therapeutics-nicotinamide-riboside"},{"target_artifact_id":"wiki-therapeutics-natural-compound-therapies-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-natural-compound-therapies-neurodegeneration"},{"target_artifact_id":"wiki-therapeutics-pgc1-alpha-targeted-therapies","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/therapeutics-pgc1-alpha-targeted-therapies"},{"target_artifact_id":"wiki-therapeutics-adiponectin-receptor-modulators","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/therapeutics-adiponectin-receptor-modulators"},{"target_artifact_id":"wiki-therapeutics-parkin-activators-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/therapeutics-parkin-activators-parkinsons"},{"target_artifact_id":"wiki-therapeutics-section-186-bioenergetics-mitochondrial-coupling-cbs-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in 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Content: SIRT1 mentioned 28x in wiki/mechanisms-sirtuins-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-histone-modification-pathway-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 8x in wiki/mechanisms-histone-modification-pathway-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-synthetic-lethality-parp-inhibition","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 15x in wiki/mechanisms-synthetic-lethality-parp-inhibition"},{"target_artifact_id":"wiki-mechanisms-chrononutrition-time-restricted-eating","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 11x in wiki/mechanisms-chrononutrition-time-restricted-eating"},{"target_artifact_id":"wiki-mechanisms-neuroresilience","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in 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wiki/mechanisms-adiponectin-signaling-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-psp-epigenetic-changes","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/mechanisms-psp-epigenetic-changes"},{"target_artifact_id":"wiki-mechanisms-epigenetic-alterations-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 7x in wiki/mechanisms-epigenetic-alterations-ad"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-pathway","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 64x in wiki/mechanisms-sirtuin-signaling-pathway"},{"target_artifact_id":"wiki-mechanisms-circadian-disruption-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/mechanisms-circadian-disruption-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-chromatin-remodeling-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 7x in wiki/mechanisms-chromatin-remodeling-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 9x in wiki/mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 38x in wiki/mechanisms-sirtuin-signaling-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-sleep-circadian-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 6x in wiki/mechanisms-sleep-circadian-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis"},{"target_artifact_id":"wiki-mechanisms-epigenetic-disease-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 9x in wiki/mechanisms-epigenetic-disease-comparison"},{"target_artifact_id":"wiki-mechanisms-nrf2-signaling-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 7x in wiki/mechanisms-nrf2-signaling-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-pathway","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-pathway"},{"target_artifact_id":"wiki-mechanisms-circadian-disruption-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 10x in wiki/mechanisms-circadian-disruption-parkinsons"},{"target_artifact_id":"wiki-mechanisms-ampk-activators-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/mechanisms-ampk-activators-parkinsons"},{"target_artifact_id":"wiki-mechanisms-nad-signaling-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 8x in wiki/mechanisms-nad-signaling-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-sirtuin-signaling-4r-tauopathies","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 24x in wiki/mechanisms-sirtuin-signaling-4r-tauopathies"},{"target_artifact_id":"wiki-mechanisms-chromatin-remodeling","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 12x in wiki/mechanisms-chromatin-remodeling"},{"target_artifact_id":"wiki-mechanisms-energy-metabolism-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/mechanisms-energy-metabolism-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-hdac-inhibitor-mechanism","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 6x in wiki/mechanisms-hdac-inhibitor-mechanism"},{"target_artifact_id":"wiki-mechanisms-ad-epigenetic-alterations-pathway","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 12x in wiki/mechanisms-ad-epigenetic-alterations-pathway"},{"target_artifact_id":"wiki-entities-hdac-enzymes","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 6x in wiki/entities-hdac-enzymes"},{"target_artifact_id":"wiki-entities-rnf128","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 28x in wiki/entities-rnf128"},{"target_artifact_id":"wiki-brain-regions-ventral-tegmental-area","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/brain-regions-ventral-tegmental-area"},{"target_artifact_id":"wiki-experiments-sirtuin-pathway-dysfunction-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 9x in wiki/experiments-sirtuin-pathway-dysfunction-parkinsons"},{"target_artifact_id":"wiki-experiments-sirtuin-dysfunction-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 14x in wiki/experiments-sirtuin-dysfunction-parkinsons"},{"target_artifact_id":"wiki-diseases-cockayne-syndrome","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 4x in wiki/diseases-cockayne-syndrome"},{"target_artifact_id":"wiki-ai-tool-alibaba-tongyi-qianwen-bio","link_type":"related","strength":0.7,"evidence":"disease: neurodegeneration"},{"target_artifact_id":"wiki-technologies-crispr-gene-editing-neurodegeneration","link_type":"related","strength":0.4,"evidence":"KG bridge: CRISPR ↔ PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes"},{"target_artifact_id":"wiki-cell-types-cell-atlas-coverage","link_type":"related","strength":0.4,"evidence":"KG bridge: RNA ↔ PGC1A, SIRT1, FOXO3, mitochondrial biogenesis 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match"},{"target_artifact_id":"wiki-therapeutics-section-194-mitochondrial-dynamics-biogenesis-therapy-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via biogenesis match"},{"target_artifact_id":"wiki-therapeutics-section-201-mitochondrial-biogenesis-pgc1alpha-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via biogenesis match"},{"target_artifact_id":"wiki-proteins-pex6-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via biogenesis match"},{"target_artifact_id":"wiki-proteins-pex2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via biogenesis match"},{"target_artifact_id":"wiki-genes","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via genes match"},{"target_artifact_id":"wiki-therapeutics-neurogenesis-therapies-neurodegeneration","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via genes 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wiki/therapeutics-cd38-inhibitor-therapy-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-cbs-psp-treatment-rankings","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-cbs-psp-treatment-rankings"},{"source_artifact_id":"wiki-therapeutics-section-103-sirtuin-nad-cbs-psp","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 29x in wiki/therapeutics-section-103-sirtuin-nad-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-ampk-activators","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/therapeutics-ampk-activators"},{"source_artifact_id":"wiki-therapeutics-nicotinamide-mononucleotide-nmn","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/therapeutics-nicotinamide-mononucleotide-nmn"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons-disease","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 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wiki/therapeutics-pgc1-alpha-activator-therapy"},{"source_artifact_id":"wiki-therapeutics-mitochondrial-therapies-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-mitochondrial-therapies-neurodegeneration"},{"source_artifact_id":"wiki-therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-resveratrol-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 16x in wiki/therapeutics-resveratrol-neurodegeneration"},{"source_artifact_id":"wiki-clinical-trials-tocotrienols-pd-nct04491383","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/clinical-trials-tocotrienols-pd-nct04491383"},{"source_artifact_id":"wiki-clinical-trials-coq10-qe3","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/clinical-trials-coq10-qe3"},{"source_artifact_id":"wiki-clinical-trials-nadapt-study-nad-replenishment-parkinsonism-nct06162013","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/clinical-trials-nadapt-study-nad-replenishment-parkinsonism-nct06162013"},{"source_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/clinical-trials-nct07062198"},{"source_artifact_id":"wiki-hypotheses-sirtuin-pathway-dysfunction-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 41x in wiki/hypotheses-sirtuin-pathway-dysfunction-parkinsons"},{"source_artifact_id":"wiki-ideas-cd38-inhibition-nad-synergy","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/ideas-cd38-inhibition-nad-synergy"},{"source_artifact_id":"wiki-ideas-mitochondrial-nad-redox-swing-protocol","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"source_artifact_id":"wiki-ideas-payload-insulin-glp1-combo-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-insulin-glp1-combo-therapy"},{"source_artifact_id":"wiki-ideas-combination-logic-ideas","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-combination-logic-ideas"},{"source_artifact_id":"wiki-ideas-novel-therapy-index","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/ideas-novel-therapy-index"},{"source_artifact_id":"wiki-ideas-parp1-inhibition-parthanatos-prevention","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/ideas-parp1-inhibition-parthanatos-prevention"},{"source_artifact_id":"wiki-ideas-payload-mitochondrial-nad-redox-swing","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 14x in wiki/ideas-payload-mitochondrial-nad-redox-swing"},{"source_artifact_id":"wiki-ideas-payload-epigenetic-clock-reversal-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-epigenetic-clock-reversal-therapy"},{"source_artifact_id":"wiki-ideas-payload-m6a-rna-methylation-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-m6a-rna-methylation-modulation-therapy"},{"source_artifact_id":"wiki-ideas-payload-crmp2-phosphorylation-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-payload-crmp2-phosphorylation-modulation-therapy"},{"source_artifact_id":"wiki-ideas-payload-checkpoint-kinase-modulation-therapy","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/ideas-payload-checkpoint-kinase-modulation-therapy"},{"source_artifact_id":"wiki-ideas-payload-notch-signaling-modulation-therapy","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/ideas-payload-notch-signaling-modulation-therapy"},{"source_artifact_id":"wiki-ideas-ulnk1-2-kinase-modulation-mitophagy","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/ideas-ulnk1-2-kinase-modulation-mitophagy"},{"source_artifact_id":"wiki-ideas-mitochondrial-nad-redox-swing","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 6x in wiki/ideas-mitochondrial-nad-redox-swing"},{"source_artifact_id":"wiki-investment-sirtuin-therapeutics-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 20x in wiki/investment-sirtuin-therapeutics-neurodegeneration"},{"source_artifact_id":"wiki-investment-epigenetic-therapy-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 8x in wiki/investment-epigenetic-therapy-neurodegeneration"},{"source_artifact_id":"wiki-cell-types-striatum-procedural-memory","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-striatum-procedural-memory"},{"source_artifact_id":"wiki-cell-types-resilient-neurons-alzheimers","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-resilient-neurons-alzheimers"},{"source_artifact_id":"wiki-cell-types-caudate-nucleus-projection","link_type":"mentions","strength":0.5,"evidence":"Content: FOXO3 mentioned 2x in wiki/cell-types-caudate-nucleus-projection"},{"source_artifact_id":"wiki-cell-types-glucose-metabolism-vulnerable-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-glucose-metabolism-vulnerable-neurons"},{"source_artifact_id":"wiki-cell-types-mitochondrial-dysfunction-dopaminergic","link_type":"mentions","strength":0.5,"evidence":"Content: FOXO3 mentioned 2x in wiki/cell-types-mitochondrial-dysfunction-dopaminergic"},{"source_artifact_id":"wiki-cell-types-circadian-neurons-in-neurodegeneration","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/cell-types-circadian-neurons-in-neurodegeneration"},{"source_artifact_id":"wiki-cell-types-circadian-dysfunction-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-circadian-dysfunction-neurons"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-expanded","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-ventral-tegmental-area-expanded"},{"source_artifact_id":"wiki-cell-types-telomere-dysfunction-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-telomere-dysfunction-neurons"},{"source_artifact_id":"wiki-cell-types-circadian-clock-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/cell-types-circadian-clock-neurons"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/cell-types-ventral-tegmental-area"},{"source_artifact_id":"wiki-mechanisms-epigenetics-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetics-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-sirtuins-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 28x in wiki/mechanisms-sirtuins-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-quality-control-network-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitochondrial-quality-control-network-pathway"},{"source_artifact_id":"wiki-mechanisms-ampk-signaling-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-ampk-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-pathway"},{"source_artifact_id":"wiki-mechanisms-nfkb-signaling-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-nfkb-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-sirtuin-mitochondrial-biogenesis-axis","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 24x in wiki/mechanisms-sirtuin-mitochondrial-biogenesis-axis"},{"source_artifact_id":"wiki-mechanisms-astrocyte-senescence-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-astrocyte-senescence-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-dna-damage-ad-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-dna-damage-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-hub","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-hub"},{"source_artifact_id":"wiki-mechanisms-nrf2-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-nrf2-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-regulation","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetic-regulation"},{"source_artifact_id":"wiki-mechanisms-histone-modification-pathway-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-histone-modification-pathway-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-ampk-mitochondrial-quality-control","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-ampk-mitochondrial-quality-control"},{"source_artifact_id":"wiki-mechanisms-synthetic-lethality-parp-inhibition","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 15x in wiki/mechanisms-synthetic-lethality-parp-inhibition"},{"source_artifact_id":"wiki-mechanisms-circadian-dysfunction-ad-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-circadian-dysfunction-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-chrononutrition-time-restricted-eating","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 11x in wiki/mechanisms-chrononutrition-time-restricted-eating"},{"source_artifact_id":"wiki-mechanisms-neuroresilience","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-neuroresilience"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-ad-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-dysfunction-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-neuroimmune-metabolic-convergence-therapy-synthesis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-neuroimmune-metabolic-convergence-therapy-synthesis"},{"source_artifact_id":"wiki-mechanisms-nfkb-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-nfkb-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 54x in wiki/mechanisms-sirtuin-signaling-parkinsons"},{"source_artifact_id":"wiki-technologies-p300-bci","link_type":"mentions","strength":0.5,"evidence":"Content: FOXO3 mentioned 2x in wiki/technologies-p300-bci"},{"source_artifact_id":"wiki-mechanisms-target-family-consolidation-analysis","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-target-family-consolidation-analysis"},{"source_artifact_id":"wiki-mechanisms-citric-acid-cycle","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-citric-acid-cycle"},{"source_artifact_id":"wiki-mechanisms-creb-independent-neuronal-survival-pathways","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-creb-independent-neuronal-survival-pathways"},{"source_artifact_id":"wiki-mechanisms-heat-shock-protein-response-neurodegeneration","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-heat-shock-protein-response-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-transcriptional-regulation","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-transcriptional-regulation"},{"source_artifact_id":"wiki-mechanisms-geroprotective-therapies-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-geroprotective-therapies-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-alpha-synuclein-autophagy-clearance","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-alpha-synuclein-autophagy-clearance"},{"source_artifact_id":"wiki-mechanisms-adiponectin-signaling-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-adiponectin-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-psp-epigenetic-changes","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-psp-epigenetic-changes"},{"source_artifact_id":"wiki-mechanisms-epigenetic-alterations-ad","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-epigenetic-alterations-ad"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-pathway","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 64x in wiki/mechanisms-sirtuin-signaling-pathway"},{"source_artifact_id":"wiki-mechanisms-circadian-disruption-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-circadian-disruption-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-chromatin-remodeling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 9x in wiki/mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 38x in wiki/mechanisms-sirtuin-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-mitochondrial-dysfunction-parkinsons"},{"source_artifact_id":"wiki-mechanisms-sleep-circadian-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-sleep-circadian-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis"},{"source_artifact_id":"wiki-mechanisms-epigenetic-disease-comparison","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 9x in wiki/mechanisms-epigenetic-disease-comparison"},{"source_artifact_id":"wiki-mechanisms-nrf2-signaling-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 7x in wiki/mechanisms-nrf2-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-energy-metabolism-dysfunction-comparison","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-energy-metabolism-dysfunction-comparison"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-pathway","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-clocks-brain-aging","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-epigenetic-clocks-brain-aging"},{"source_artifact_id":"wiki-mechanisms-pink1-parkin-mitophagy-activators-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-pink1-parkin-mitophagy-activators-parkinsons"},{"source_artifact_id":"wiki-mechanisms-transcription-regulation","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-transcription-regulation"},{"source_artifact_id":"wiki-mechanisms-circadian-disruption-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-circadian-disruption-parkinsons"},{"source_artifact_id":"wiki-mechanisms-ampk-activators-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-ampk-activators-parkinsons"},{"source_artifact_id":"wiki-mechanisms-nad-signaling-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 8x in wiki/mechanisms-nad-signaling-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-sirtuin-signaling-4r-tauopathies","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 24x in wiki/mechanisms-sirtuin-signaling-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-circadian-rhythm-dysfunction-4r-tauopathies","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-circadian-rhythm-dysfunction-4r-tauopathies"},{"source_artifact_id":"wiki-mechanisms-tfeb-autophagy-pathway","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-tfeb-autophagy-pathway"},{"source_artifact_id":"wiki-mechanisms-rna-metabolism-alzheimers-disease","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-rna-metabolism-alzheimers-disease"},{"source_artifact_id":"wiki-mechanisms-epigenetics-als","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetics-als"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 12x in wiki/mechanisms-chromatin-remodeling"},{"source_artifact_id":"wiki-mechanisms-rna-dysregulation-ad","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-rna-dysregulation-ad"},{"source_artifact_id":"wiki-mechanisms-epigenetics-parkinsons","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetics-parkinsons"},{"source_artifact_id":"wiki-mechanisms-circadian-rhythm-disruption-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-circadian-rhythm-disruption-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-unfolded-protein-response","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 10x in wiki/mechanisms-mitochondrial-unfolded-protein-response"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-parkinsons-pathway","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-pgc1alpha-parkinsons-pathway"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-comparison","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-epigenetic-dysregulation-comparison"},{"source_artifact_id":"wiki-mechanisms-alpha-klotho-neurodegeneration","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-alpha-klotho-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-huntingtin-mitochondrial-dysfunction","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-huntingtin-mitochondrial-dysfunction"},{"source_artifact_id":"wiki-mechanisms-energy-metabolism-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/mechanisms-energy-metabolism-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 16x in wiki/mechanisms-epigenetic-dysregulation-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-dna-damage-response-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/mechanisms-dna-damage-response-parkinsons"},{"source_artifact_id":"wiki-mechanisms-hdac-inhibitor-mechanism","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 6x in wiki/mechanisms-hdac-inhibitor-mechanism"},{"source_artifact_id":"wiki-mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/mechanisms-pgc1alpha-mitochondrial-biogenesis-comparison"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-quality-control","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/mechanisms-mitochondrial-quality-control"},{"source_artifact_id":"wiki-mechanisms-ad-epigenetic-alterations-pathway","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 12x in wiki/mechanisms-ad-epigenetic-alterations-pathway"},{"source_artifact_id":"wiki-technologies-wearable-sensors-parkinsonism","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/technologies-wearable-sensors-parkinsonism"},{"source_artifact_id":"wiki-entities-mitochondrial-dynamics","link_type":"mentions","strength":0.55,"evidence":"Content: SIRT1 mentioned 3x in wiki/entities-mitochondrial-dynamics"},{"source_artifact_id":"wiki-entities-hdac-enzymes","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 6x in wiki/entities-hdac-enzymes"},{"source_artifact_id":"wiki-entities-histone-deacetylase","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/entities-histone-deacetylase"},{"source_artifact_id":"wiki-entities-rnf128","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 28x in wiki/entities-rnf128"},{"source_artifact_id":"wiki-brain-regions-brainstem","link_type":"mentions","strength":0.55,"evidence":"Content: FOXO3 mentioned 3x in wiki/brain-regions-brainstem"},{"source_artifact_id":"wiki-brain-regions-ventral-tegmental-area","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/brain-regions-ventral-tegmental-area"},{"source_artifact_id":"wiki-experiments-sirtuin-pathway-dysfunction-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 9x in wiki/experiments-sirtuin-pathway-dysfunction-parkinsons"},{"source_artifact_id":"wiki-experiments-sirtuin-dysfunction-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 14x in wiki/experiments-sirtuin-dysfunction-parkinsons"},{"source_artifact_id":"wiki-experiments-circadian-vascular-metabolic-syndrome-ad","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 2x in wiki/experiments-circadian-vascular-metabolic-syndrome-ad"},{"source_artifact_id":"wiki-diseases-cockayne-syndrome","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 4x in wiki/diseases-cockayne-syndrome"},{"source_artifact_id":"wiki-therapeutics-section-151-thyroid-metabolic-hormone-optimization-cbs-psp","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-827a821b: ...rcuits](/hypothesis/h-827a821b) — <span 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