{"artifact":{"id":"hypothesis-h-9d22b570","artifact_type":"hypothesis","entity_ids":"[\"NURR1\", \"PITX3\", \"NEURONAL IDENTITY TRANSCRIPTION FACTORS\"]","title":"Programmable Neuronal Circuit Repair via Epigenetic CRISPR","quality_score":0.37,"created_by":"import","provenance_chain":null,"content_hash":"801cf6d5b5a73242bea6923e16bcdf898ead78f6a9572383023ffffe6918e65b","metadata":{"status":"proposed","disease":"neurodegeneration","analysis_id":"SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","target_gene":"NURR1, PITX3, neuronal identity transcription factors","target_pathway":null,"_schema_version":1,"composite_score":0.37},"created_at":"2026-04-02T20:53:07-07:00","updated_at":"2026-04-02T16:29:15.880371-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T20:53:07-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5b1a335b-071f-426d-a7e4-9c1dfdbd6076","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"import"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-therapeutics-nurr1-agonist-therapy","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-therapeutics-nurr1-agonists-parkinsons","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-therapeutics-nurr1-agonist-therapies","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-nr4a2-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-nurr1","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-mechanisms-nurr1-nr4a2-pathway-parkinsons","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-pitx3-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via PITX3 match"},{"target_artifact_id":"wiki-therapeutics-neuronal-stem-cell-transplantation-neurodegeneration","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-147-neuroimmune-glial-crosstalk-cbs-psp","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-242-advanced-stem-cell-therapy-neuronal-replacement-cbs-psp","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-cellular-reprogramming-neuronal-replacement","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-147-neuroimmune-interface-glial-crosstalk-cbs-psp","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-proteins-nos1","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-proteins-kcnh3-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-genes-cln8","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via neuronal match"},{"target_artifact_id":"wiki-cell-types-social-identity-cells","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via identity match"},{"target_artifact_id":"wiki-proteins-tfeb","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-e2f2-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-olig1-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-atf2-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-stat4-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-sin3a-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-mafb-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-atf4-protein","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via transcription match"},{"target_artifact_id":"wiki-investment-neurotrophic-factors","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-psp-environmental-risk-factors","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-vascular-risk-factors-alzheimers","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-msa-genetics-risk-factors","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-pd-genetic-penetrance","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-environmental-risk-factors","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-modifiable-risk-factors","link_type":"related","strength":0.81,"evidence":"Reverse: Cross-linked via factors match"},{"target_artifact_id":"wiki-diseases-nbia","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-mpan","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-bpan","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-disease-progression","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-pkan","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-diseases-manganism","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-clinical-trials-beacon-study-nct03860857","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-clinical-trials-olfactory-mucosa-early-neurodegeneration-nct06846658","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-clinical-trials-gut-brain-axis-neurodegeneration-nct05934188","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-clinical-trials-swedish-biofinder-2-psp-nct03174938","link_type":"related","strength":0.54,"evidence":"Reverse: Disease page related to hypothesis disease: neurodegeneration"},{"target_artifact_id":"wiki-mechanisms-substantia-nigra-selective-vulnerability-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dat-dysfunction-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopaminergic-neuron-vulnerability","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-pd-dopamine-metabolism","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-trace-amine-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-mesolimbic-dopamine-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-complement-system-activation-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-epigenetics-ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-protein-quality-control-network","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-mitochondrial-quality-control-network-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-htt-huntingtin-hd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopaminergic-vulnerability","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-factor-signaling-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-complement-activation-cbd","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-gene-mechanism-therapy-causal-chains","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-cbs-pyroptosis-inflammasome-activation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-transcription-regulation-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-mlcs-parkinsons-ipsc-methods","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-cbs-psp-genetic-architecture","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopaminergic-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-lrrk2-kinase-endolysosomal-dysfunction-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-nonfluent-agrammatic-ppa-mechanisms","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopamine-metabolism","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-pre-symptomatic-conversion-als","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-amyloid-beta-trans-synaptic-spread-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-syk-kinase-microglial-activation-alzheimers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-tau-oligodendrocyte-methylation-ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-factor-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-network-functional-connectivity-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-nlrp3-inflammasome-activation-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-psp-pyroptosis-inflammasome-activation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-mds-2026-pd-genetic-molecular-mechanisms","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-cr1-complement-synaptic-pruning-ad-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dian","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-semantic-variant-ftd-mechanisms","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-psp-neurotrophic-factor-dysfunction","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopamine-biosynthesis-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-proteostasis-network","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopamine-oxidation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-gba-parkinson-risk","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-cbs-network-spreading","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopamine-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-aav-gene-therapy-vectors-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-tau-network-propagation-hypothesis","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-gdnf-neurotrophic-signaling-pathway","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-proteostasis-network-comparison","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-transcription-regulation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-fus-als-ftd-causal-chain","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-bdnf-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-epigenetics-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-behavioral-variant-ftd-mechanisms","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-growth-factor-signaling-4r-tauopathies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-neurotrophic-factor-decline","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-non-dopaminergic-neurotransmitter-degeneration-parkinsons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-syk-microglial-activation-alzheimers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-psp-brain-network-connectivity","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-fibroblast-growth-factor-signaling-neurodegeneration","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-c9orf72-als-network","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-network-pharmacology-neurodegeneration-synthesis","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-lrrk2-14-3-3-interaction-network","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-network-oscillation-dysfunction","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-microglia-activation","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-4r-tauopathy-genetic-comparison","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dopamine-signaling","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-brain-network-connectivity-psp","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-dj1-pten-p53-network","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-mechanisms-neural-network-dysfunction-alzheimers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"wiki-cell-types-dopaminergic-neurons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Dopaminergic Neurons"},{"target_artifact_id":"wiki-mechanisms","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Mechanisms"},{"target_artifact_id":"wiki-mechanisms-genetics","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: genetics"},{"target_artifact_id":"wiki-clinical-trials","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Clinical Trials"},{"target_artifact_id":"wiki-diseases-parkinsons-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Parkinson's Disease"},{"target_artifact_id":"wiki-cell-types-motor-neurons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Motor Neurons"},{"target_artifact_id":"wiki-technologies-optogenetics","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Optogenetics"},{"target_artifact_id":"wiki-diseases-amyotrophic-lateral-sclerosis","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Amyotrophic Lateral Sclerosis"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Alzheimer's Disease"},{"target_artifact_id":"wiki-cell-types-substantia-nigra","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Substantia Nigra Neurons"},{"target_artifact_id":"wiki-brain-regions","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Brain Regions"},{"target_artifact_id":"wiki-diseases-huntingtons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Huntington's Disease"},{"target_artifact_id":"wiki-technologies","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Technologies"},{"target_artifact_id":"wiki-cell-types","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Cell Types"},{"target_artifact_id":"wiki-cell-types-cholinergic-neurons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Cholinergic Neurons"},{"target_artifact_id":"wiki-cell-types-glutamatergic-neurons","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Glutamatergic Neurons"},{"target_artifact_id":"wiki-therapeutics","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: Therapeutics"},{"target_artifact_id":"wiki-mechanisms-parkinsons-disease-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Content: NURR1 mentioned 4x in wiki/mechanisms-parkinsons-disease-mechanisms"},{"target_artifact_id":"wiki-ai-tool-alibaba-tongyi-qianwen-bio","link_type":"related","strength":0.7,"evidence":"disease: neurodegeneration"},{"target_artifact_id":"wiki-genes-en1","link_type":"mentions","strength":0.5,"evidence":"Entity EN1 in hypothesis text"},{"target_artifact_id":"wiki-genes-ascl1","link_type":"mentions","strength":0.5,"evidence":"Entity ASCL1 in hypothesis text"},{"target_artifact_id":"wiki-genes-lmx1a","link_type":"mentions","strength":0.5,"evidence":"Entity LMX1A in hypothesis text"},{"target_artifact_id":"wiki-genes-scn9a","link_type":"mentions","strength":0.5,"evidence":"Entity SCN9A in hypothesis text"},{"target_artifact_id":"wiki-genes-map6","link_type":"mentions","strength":0.5,"evidence":"Entity MAP6 in hypothesis text"},{"target_artifact_id":"wiki-genes-ptbp1","link_type":"mentions","strength":0.5,"evidence":"Entity PTBP1 in hypothesis text"},{"target_artifact_id":"wiki-genes-foxa2","link_type":"mentions","strength":0.5,"evidence":"Entity FOXA2 in hypothesis text"},{"target_artifact_id":"wiki-genes-map2","link_type":"mentions","strength":0.5,"evidence":"Entity MAP2 in hypothesis text"},{"target_artifact_id":"wiki-genes-en2","link_type":"mentions","strength":0.5,"evidence":"Entity EN2 in hypothesis text"},{"target_artifact_id":"wiki-technologies-crispr-gene-editing-neurodegeneration","link_type":"related","strength":0.4,"evidence":"KG bridge: CRISPR ↔ NURR1, PITX3, neuronal identity transcription factors"},{"target_artifact_id":"wiki-cell-types-cell-atlas-coverage","link_type":"related","strength":0.4,"evidence":"KG bridge: RNA ↔ NURR1, PITX3, neuronal identity transcription factors"},{"target_artifact_id":"wiki-therapeutics-nurr1-agonist-therapy","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-therapeutics-nurr1-agonists-parkinsons","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-therapeutics-nurr1-agonist-therapies","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-nr4a2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-nurr1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-genes-nurr1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-mechanisms-nurr1-nr4a2-pathway-parkinsons","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"target_artifact_id":"wiki-proteins-pitx3-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via PITX3 match"},{"target_artifact_id":"wiki-genes-pitx3","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via PITX3 match"},{"target_artifact_id":"wiki-therapeutics-neuronal-stem-cell-transplantation-neurodegeneration","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-147-neuroimmune-glial-crosstalk-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-242-advanced-stem-cell-therapy-neuronal-replacement-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-cellular-reprogramming-neuronal-replacement","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-therapeutics-section-147-neuroimmune-interface-glial-crosstalk-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-proteins-nos1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-proteins-kcnh3-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-genes-cln8","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"target_artifact_id":"wiki-cell-types-social-identity-cells","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via identity match"},{"target_artifact_id":"wiki-proteins-tfeb","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-e2f2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-olig1-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-atf2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-stat4-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-sin3a-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-mafb-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-proteins-atf4-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"target_artifact_id":"wiki-investment-neurotrophic-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-psp-environmental-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-vascular-risk-factors-alzheimers","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-msa-genetics-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-pd-genetic-penetrance","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-environmental-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-mechanisms-modifiable-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"target_artifact_id":"wiki-circuits","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-therapeutics-section-253-optogenetics-chemogenetics-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-therapeutics-section-253-advanced-optogenetics-chemogenetics-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-clinical-trials-circuit-based-dbs-parkinson","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-clinical-trials-circuit-based-dbs-nct05658302","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-circuits-olfactory-limbic-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-circuits-interhemispheric-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-circuits-hippocampal-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"target_artifact_id":"wiki-therapeutics-dna-damage-repair-therapy","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-section-144-advanced-myelin-repair-oligodendrocyte-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-section-146-advanced-synaptic-plasticity-network-repair-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-myelin-repair","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-dna-repair-therapy-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-section-128-myelin-repair-remyelination-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-proteins-ercc2-protein","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-proteins-xrcc2-protein","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"target_artifact_id":"wiki-therapeutics-section-248-epigenetic-clock-reversal-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-epigenetic-therapies-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-epigenetic-reprogramming","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons-disease","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-therapeutics-epigenetic-editing-crispr-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"target_artifact_id":"wiki-genes-nurr1","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene NURR1 described in wiki"},{"target_artifact_id":"wiki-genes-pitx3","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene PITX3 described in wiki"},{"target_artifact_id":"wiki-neurodegeneration","link_type":"related","strength":0.8,"evidence":"Hypothesis relates to disease described in wiki"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"derives_from","strength":0.95,"evidence":"Hypothesis derives from this analysis"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Disease: neurodegeneration"},{"target_artifact_id":"wiki-genes-nr4a2","link_type":"mentions","strength":0.5,"evidence":"Entity NR4A2 in hypothesis text"},{"target_artifact_id":"wiki-genes-vmat2","link_type":"mentions","strength":0.5,"evidence":"Entity VMAT2 in hypothesis text"},{"target_artifact_id":"wiki-genes-sox9","link_type":"mentions","strength":0.5,"evidence":"Entity SOX9 in hypothesis text"},{"target_artifact_id":"wiki-genes-ezh2","link_type":"mentions","strength":0.5,"evidence":"Entity EZH2 in hypothesis text"},{"target_artifact_id":"wiki-genes-dnmt3a","link_type":"mentions","strength":0.5,"evidence":"Entity DNMT3A in hypothesis text"},{"target_artifact_id":"wiki-genes-olig2","link_type":"mentions","strength":0.5,"evidence":"Entity OLIG2 in hypothesis text"},{"target_artifact_id":"wiki-genes-chat","link_type":"mentions","strength":0.5,"evidence":"Entity CHAT in hypothesis text"},{"target_artifact_id":"wiki-genes-lrrk2","link_type":"mentions","strength":0.5,"evidence":"Entity LRRK2 in hypothesis text"},{"target_artifact_id":"wiki-genes-rank","link_type":"related","strength":0.4,"evidence":"KG bridge: RANK ↔ NURR1, PITX3, neuronal identity transcription factors"},{"target_artifact_id":"wiki-entities-sirt1","link_type":"related","strength":0.4,"evidence":"KG bridge: SIRT1 ↔ NURR1, PITX3, neuronal identity transcription factors"},{"target_artifact_id":"wiki-genes-pafah1b1","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'FACTOR' found in hypothesis pathway"},{"target_artifact_id":"wiki-genes-prpf3","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'FACTOR' found in hypothesis pathway"},{"target_artifact_id":"wiki-genes-sdhaf2","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'FACTOR' found in hypothesis pathway"},{"target_artifact_id":"wiki-genes-prpf6","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'FACTOR' found in hypothesis pathway"},{"target_artifact_id":"wiki-genes-tfap4","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'TRANSCRIPTION' found in hypothesis pathway"},{"target_artifact_id":"wiki-genes-arhgef28","link_type":"see_also","strength":0.5,"evidence":"Reverse: Wiki title word 'FACTOR' found in hypothesis pathway"},{"target_artifact_id":"wiki-proteins-nurr1","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene NURR1 discussed in wiki page"},{"target_artifact_id":"wiki-genes-nurr1","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene NURR1 discussed in wiki page"},{"target_artifact_id":"wiki-genes-pitx3","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene PITX3 discussed in wiki page"}],"incoming_links":[{"source_artifact_id":"wiki-cell-types-aldh1a1-dopamine-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PITX3 mentioned 2x in wiki/cell-types-aldh1a1-dopamine-neurons"},{"source_artifact_id":"wiki-cell-types-claustrum","link_type":"mentions","strength":0.5,"evidence":"Content: NURR1 mentioned 2x in wiki/cell-types-claustrum"},{"source_artifact_id":"wiki-cell-types-ventral-midbrain-dopamine-neurons-development","link_type":"mentions","strength":0.5,"evidence":"Content: NURR1 mentioned 2x in wiki/cell-types-ventral-midbrain-dopamine-neurons-development"},{"source_artifact_id":"wiki-cell-types-ipsc-derived-dopamine-neurons","link_type":"mentions","strength":0.55,"evidence":"Content: NURR1 mentioned 3x in wiki/cell-types-ipsc-derived-dopamine-neurons"},{"source_artifact_id":"wiki-cell-types-ipsc-derived-dopaminergic-neurons","link_type":"mentions","strength":0.55,"evidence":"Content: PITX3 mentioned 3x in wiki/cell-types-ipsc-derived-dopaminergic-neurons"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area","link_type":"mentions","strength":0.5,"evidence":"Content: NURR1 mentioned 2x in wiki/cell-types-ventral-tegmental-area"},{"source_artifact_id":"wiki-cell-types-vulnerable-substantia-nigra-dopamine-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PITX3 mentioned 2x in wiki/cell-types-vulnerable-substantia-nigra-dopamine-neurons"},{"source_artifact_id":"wiki-mechanisms-parkinsons-disease-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Content: NURR1 mentioned 4x in wiki/mechanisms-parkinsons-disease-mechanisms"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-dopamine-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: NURR1 mentioned 2x in wiki/cell-types-ventral-tegmental-area-dopamine-neurodegeneration"},{"source_artifact_id":"wiki-cell-types-primary-motor-cortex-layer-5-betz-cells","link_type":"mentions","strength":0.55,"evidence":"Content: PITX3 mentioned 3x in wiki/cell-types-primary-motor-cortex-layer-5-betz-cells"},{"source_artifact_id":"wiki-therapeutics-section-144-advanced-myelin-repair-oligodendrocyte-therapy-cbs-psp","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-therapeutics-section-146-advanced-synaptic-plasticity-network-repair-cbs-psp","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-therapeutics-myelin-repair","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-therapeutics-section-253-optogenetics-chemogenetics-cbs-psp","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-proteins-app","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-genes-app","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-ideas-payload-app-dosage-reduction-ds-therapy","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-9d22b570: ...CRISPR](/hypothesis/h-9d22b570) — <span style=\"col..."},{"source_artifact_id":"wiki-ai-tool-alibaba-tongyi-qianwen-bio","link_type":"related","strength":0.7,"evidence":"disease: neurodegeneration"},{"source_artifact_id":"wiki-genes-en1","link_type":"mentions","strength":0.5,"evidence":"Entity EN1 in hypothesis text"},{"source_artifact_id":"wiki-genes-en2","link_type":"mentions","strength":0.5,"evidence":"Entity EN2 in hypothesis text"},{"source_artifact_id":"wiki-technologies-crispr-gene-editing-neurodegeneration","link_type":"related","strength":0.4,"evidence":"KG bridge: CRISPR ↔ NURR1, PITX3, neuronal identity transcription factors"},{"source_artifact_id":"wiki-cell-types-cell-atlas-coverage","link_type":"related","strength":0.4,"evidence":"KG bridge: RNA ↔ NURR1, PITX3, neuronal identity transcription factors"},{"source_artifact_id":"wiki-mpan","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'mpan' — entity matches hypothesis target"},{"source_artifact_id":"wiki-proteins-bdnf","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-bdnf","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-sirt1","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-entities-sirt1","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-proteins-foxo3","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-foxo3","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-ldlr","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-proteins-nurr1","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-nurr1","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-pgc1a","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-htt","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-pitx3","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-dmpk","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-creb1","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-genes-hmgcr","link_type":"related","strength":0.4,"evidence":null},{"source_artifact_id":"wiki-therapeutics-nurr1-agonist-therapy","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-therapeutics-nurr1-agonists-parkinsons","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-therapeutics-nurr1-agonist-therapies","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-proteins-nr4a2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-proteins-nurr1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-genes-nurr1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-mechanisms-nurr1-nr4a2-pathway-parkinsons","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via NURR1 match"},{"source_artifact_id":"wiki-proteins-pitx3-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via PITX3 match"},{"source_artifact_id":"wiki-genes-pitx3","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via PITX3 match"},{"source_artifact_id":"wiki-therapeutics-neuronal-stem-cell-transplantation-neurodegeneration","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-therapeutics-section-147-neuroimmune-glial-crosstalk-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-therapeutics-section-242-advanced-stem-cell-therapy-neuronal-replacement-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-therapeutics-cellular-reprogramming-neuronal-replacement","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-therapeutics-section-147-neuroimmune-interface-glial-crosstalk-cbs-psp","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-proteins-nos1","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-proteins-kcnh3-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-genes-cln8","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via neuronal match"},{"source_artifact_id":"wiki-cell-types-social-identity-cells","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via identity match"},{"source_artifact_id":"wiki-proteins-tfeb","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-e2f2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-olig1-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-atf2-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-stat4-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-sin3a-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-mafb-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-proteins-atf4-protein","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via transcription match"},{"source_artifact_id":"wiki-investment-neurotrophic-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-psp-environmental-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-vascular-risk-factors-alzheimers","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-msa-genetics-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-pd-genetic-penetrance","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-environmental-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-mechanisms-modifiable-risk-factors","link_type":"mentions","strength":0.9,"evidence":"Cross-linked via factors match"},{"source_artifact_id":"wiki-circuits","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-therapeutics-section-253-optogenetics-chemogenetics-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-therapeutics-section-253-advanced-optogenetics-chemogenetics-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-clinical-trials-circuit-based-dbs-parkinson","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-clinical-trials-circuit-based-dbs-nct05658302","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-circuits-olfactory-limbic-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-circuits-interhemispheric-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-circuits-hippocampal-circuit","link_type":"related","strength":0.7,"evidence":"Cross-linked via Circuit match"},{"source_artifact_id":"wiki-therapeutics-dna-damage-repair-therapy","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-section-144-advanced-myelin-repair-oligodendrocyte-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-section-146-advanced-synaptic-plasticity-network-repair-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-myelin-repair","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-dna-repair-therapy-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-section-128-myelin-repair-remyelination-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-proteins-ercc2-protein","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-proteins-xrcc2-protein","link_type":"related","strength":0.7,"evidence":"Cross-linked via Repair match"},{"source_artifact_id":"wiki-therapeutics-section-248-epigenetic-clock-reversal-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-epigenetic-reprogramming","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons-disease","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-section-203-advanced-epigenetic-chromatin-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-section-200-epigenetic-chromatin-therapy-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-therapeutics-epigenetic-editing-crispr-cbs-psp","link_type":"related","strength":0.7,"evidence":"Cross-linked via Epigenetic match"},{"source_artifact_id":"wiki-neurodegeneration","link_type":"related","strength":0.8,"evidence":"Wiki disease page related to hypothesis about neurodegeneration"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"derives_from","strength":0.95,"evidence":"Hypothesis generated from analysis debate"},{"source_artifact_id":"wiki-genes-lmx1b","link_type":"related","strength":0.5,"evidence":"Gene 'NURR1' found in wiki content"},{"source_artifact_id":"wiki-genes-smarca2","link_type":"related","strength":0.5,"evidence":"Gene 'NURR1' found in wiki content"},{"source_artifact_id":"wiki-genes-setd1b","link_type":"related","strength":0.5,"evidence":"Gene 'NURR1' found in wiki content"},{"source_artifact_id":"wiki-genes-aldh1a2","link_type":"related","strength":0.5,"evidence":"Gene 'NURR1' found in wiki content"},{"source_artifact_id":"wiki-LRRK2_inhibitors","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'LRRK2_inhibitors' — entity matches hypothesis target"},{"source_artifact_id":"wiki-LRRK2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'LRRK2' — entity matches hypothesis target"},{"source_artifact_id":"wiki-dopaminergic_neuron_death","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'dopaminergic_neuron_death' — entity matches hypothesis target"},{"source_artifact_id":"wiki-lipid_metabolism","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'lipid_metabolism' — entity matches hypothesis target"},{"source_artifact_id":"wiki-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'neuroinflammation' — entity matches hypothesis target"},{"source_artifact_id":"wiki-late","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'late' — entity matches hypothesis target"},{"source_artifact_id":"wiki-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'neurodegeneration' — entity matches hypothesis target"},{"source_artifact_id":"wiki-therapeutics-neuroprotection","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'Neuroprotection Strategies in Neurodegeneration' — entity matches hypothesis target"},{"source_artifact_id":"wiki-proteins-parkin","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'Parkin' — entity matches hypothesis target"},{"source_artifact_id":"wiki-proteins-lrrk2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'LRRK2 (Leucine-Rich Repeat Kinase 2)' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-parkin","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'PARKIN Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-olig2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'OLIG2 Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-vmat2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'VMAT2 Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-sting","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'STING Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-ezh2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'EZH2 — Enhancer of Zeste Homolog 2' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-chat","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'CHAT Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-rest","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'REST Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-tet1","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'TET1 Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-dnmt3a","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'DNMT3A Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-endog","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'ENDOG' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-sox9","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'SOX9 Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-lrrk2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'LRRK2 — Leucine Rich Repeat Kinase 2' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-nr4a2","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'NR4A2 Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-myot","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'MYOT Gene' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes-sust","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'SUMF1 - Sulfatase Modifying Factor 1' — entity matches hypothesis target"},{"source_artifact_id":"wiki-mechanisms-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'neuroinflammation' — entity matches hypothesis target"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'Neurodegeneration' — entity matches hypothesis target"},{"source_artifact_id":"wiki-diseases","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'diseases' — entity matches hypothesis target"},{"source_artifact_id":"wiki-circuits","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'circuits' — entity matches hypothesis target"},{"source_artifact_id":"wiki-events","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'events' — entity matches hypothesis target"},{"source_artifact_id":"wiki-companies","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'companies' — entity matches hypothesis target"},{"source_artifact_id":"wiki-entities","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'entities' — entity matches hypothesis target"},{"source_artifact_id":"wiki-hypotheses","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'hypotheses' — entity matches hypothesis target"},{"source_artifact_id":"wiki-genes","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'Genes' — entity matches hypothesis target"},{"source_artifact_id":"wiki-models","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'Models' — entity matches hypothesis target"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-genes-rank","link_type":"related","strength":0.4,"evidence":"KG bridge: RANK ↔ NURR1, PITX3, neuronal identity transcription factors"},{"source_artifact_id":"wiki-cell-types-mesocortical-circuit","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-neuronal-ceroid-lipofuscinosis","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-creb-independent-neuronal-survival-pathway","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-crispr-gene-editing","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-ad-epigenetic-alterations-pathway","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-dna-damage-repair","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neural-circuit-disruption","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-cellular-reprogramming-neuronal-replacement","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-crispr-gene-editing-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-mesolimbic-circuit","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-huntingtons-somatic-cag-expansion-and-dna-repair","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-death-ad","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-changes-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-4r-tauopathies","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-pdlim7-epigenetic-activation-pd","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-metabolic-epigenetic-axis-neurodegeneration-synthesis","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-selective-neuronal-vulnerability-pathway","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-cerebellar-circuit-neurons","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-hypothalamic-sleep-wake-circuit","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-disease-comparison","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-hyperexcitability","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-cbs-epigenetic-mechanisms","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-neuronal-spheroids","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-migration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-network-dysfunction-alzheimers","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-pathway","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-dna-repair-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-biomarkers-neuronal-pentraxin-1-nptx1","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-selective-neuronal-vulnerability-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-alterations-ad","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-cbs-selective-neuronal-vulnerability","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-neuronal-precursor-cells","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-non-dopaminergic-circuit-dysfunction-parkinsons","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neural-circuit-dysfunction-4r-tauopathies","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-engineered-neuronal-cells","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-neuronal-stem-cell-transplantation-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-brainstem-circuit-vulnerability-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-section-241-advanced-gene-therapy-crispr-approaches-cbs-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-crispr-gene-editing-parkinsons","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-crispr-brain-delivery","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-biomarkers-neuronal-exosome-biomarkers","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-dna-damage-repair-neurons","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-brainstem-circuit-vulnerability","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-microglial-neuronal-tauopathies","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-network-dysfunction-pathway","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-regulation","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-section-107-crispr-therapies-cbs-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-basal-ganglia-circuit-dysfunction","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-selective-neuronal-vulnerability","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-biomarkers-epigenetic-biomarkers-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-alpha-synuclein-neuronal-uptake","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-tdp43-dna-repair-als-dementia","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-neuronal-cytoskeleton-4r-tauopathies","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-nigrostriatal-circuit","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-dna-damage-repair-dysfunction","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-papez-circuit-neurons","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-clocks-brain-aging","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-dna-damage-repair-disease-comparison","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-section-242-advanced-stem-cell-therapy-neuronal-replacement-cbs-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-biomarkers-neuronal-pentraxin-receptor-nptxr","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-selective-neuronal-vulnerability","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-creb-independent-neuronal-survival-pathways","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-section-186-crispr-base-editing-therapeutics-cbs-psp","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-basal-ganglia-circuit-dysfunction-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-therapeutics-crispr-cas9-gene-therapy-neurodegeneration","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-epigenetic-changes","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-biomarkers-nptx2-neuronal-pentraxin-2","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-cell-types-neuronal-intermediate-filament-inclusion","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-comparison","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-mechanisms-psp-subcortical-circuit-dysfunction","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"source_artifact_id":"wiki-proteins-map2","link_type":"mentions","strength":0.5,"evidence":"Entity 'MAP2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-brain-connectivity-tacs-early-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-brain-computer-interface-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-brain-drug-delivery-challenges","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-clinical-trials-brain-activity-walking-atypical-parkinsonism-nct06906276","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-brain-hyperconnectivity-tau-spread-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-brain-computer-interface","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-brain-vascular-endothelial-cells","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-brain-organoids","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-capillary-endothelial-cells-brain","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-endothelial-cells-brain","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-endothelial-cells-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-venous-endothelial-cells-brain","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-pericytes-brain","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-brain-endothelial-cells","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-brain-pericytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-ependymal-cells-brain","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-brain-pericytes-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-reserve-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-volume-changes-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-region-therapeutic-targeting-index","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-endothelial-cell-dysfunction-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-4r-tauopathies-brain-region-vulnerability","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-insulin-signaling","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-brain-age-gap-amyloid-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-multiple-system-atrophy","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-parkinsons-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-knowledge-platform","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-to-brain-interface","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-organoids","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-lewy-body-dementia","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-vascular-dementia","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-frontotemporal-dementia","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-progressive-supranuclear-palsy","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-corticobasal-degeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-shuttles","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-organoids-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-computer-interfaces","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-technology-landscape","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-computer-interface","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-als","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-index","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-normal-pressure-hydrocephalus","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-waste-clearance-therapies","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-organoid-silicon-interface","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-brain-shuttle-technologies","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-bci-huntingtons-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-events-brain-health-roundtable-aadapt-act","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-brain-health-roundtable-aadapt-act","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-brain-insulin-signaling","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-brain-regions-connectivity","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-brain-regions-disease-involvement","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-brain-regions-vulnerability-map","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-brain-connectivity-tacs-early-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-institutions-brain-behavior-research-foundation","link_type":"mentions","strength":0.5,"evidence":"Entity 'BRAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-gene-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'GENE THERAPY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-gene-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'GENE THERAPY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-gene-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'GENE THERAPY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-gene-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'GENE THERAPY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-gene-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'GENE THERAPY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-complement-inhibitor-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-complement-c1q-inhibitor-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-payload-complement-pathway-inhibition-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-complement-system-therapeutics-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-coagulation-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-system-activation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-activation-cbd","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-mediated-synapse-loss","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-tauopathies-cbs","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-system-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-complement-system-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-biomarkers-complement-c3","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-gaps-complement-system-dysregulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'COMPLEMENT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-dopamine-agonists","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-dopamine-replacement-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-dopamine-agonists-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-neurons-msa","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-d3-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-neurons-adhd","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-d1-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-d5-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-vta-dopamine-reward","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-neurons-fxtas","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-d2-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-neurons-drd","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-transporter-pd","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-d4-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dat-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-neurons-reward","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dopamine-transporter-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dat-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-pd-dopamine-metabolism","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dopamine-metabolism","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dopamine-biosynthesis-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dopamine-oxidation","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dopamine-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-dopamine-signaling","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-dopamine","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-dopamine-d3-d4-selective-agonists","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-dopamine-metabolism-enzymes-beyond-comt","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-dopamine-transporter-modulators","link_type":"mentions","strength":0.5,"evidence":"Entity 'DOPAMINE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-intranasal-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-intrathecal-drug-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-liposome-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-convection-enhanced-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-nanoparticle-drug-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-exosome-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-crispr-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-cell-based-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-nanoparticle-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-aso-brain-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-lipid-nanoparticle-cns-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-intranasal-drug-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-exosome-cns-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-lipid-nanoparticle-cns-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pd-neurotrophin-gdnf-delivery","link_type":"mentions","strength":0.5,"evidence":"Entity 'DELIVERY' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-huntington-disease-treatment","link_type":"mentions","strength":0.5,"evidence":"Entity 'HUNTINGTON' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-astrocyte-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-astrocyte-metabolic-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-astrocyte-neuron-metabolic-coupling-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-payload-eaat2-glutamate-buffer-rescue","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-payload-eeat2-glutamate-buffer-rescue","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-astrocyte-neuron-reprogramming","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-astrocyte-therapeutics-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocyte-precursor-cells","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-senescence-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-reactivity-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-iron-alpha-synuclein-pathology","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-reactivity","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-neuron-metabolic-coupling","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-astrocyte-metabolic-enhancement-pd","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-biomarkers-astrocyte-exosomal-mrna-reference-genes","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-astrocyte-pd-therapy-companies","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-astrocyte-targeted-parkinsons-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-astrocyte-ferritin-iron-metabolism-pd","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-astrocyte-neuron-metabolic-coupling-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-epigenetic-reprogramming","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-parkinsons-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-epigenetic-dysregulation-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-payload-epigenetic-clock-reversal-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-combo-sirt1-nad-epigenetic-metabolic","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-epigenetic-therapy-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetics-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-regulation","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-alterations-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-disease-comparison","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-clocks-brain-aging","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetics-psp","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-epigenetic-dysregulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-ad-epigenetic-alterations-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-biomarkers-epigenetic-biomarkers-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-epigenetic-dysregulation-hd","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-epigenetic-regulation-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-epigenetic-dysregulation-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-experiments-epigenetic-clocks-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'EPIGENETIC' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-exosome-based-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-mitochondrial-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-anti-amyloid-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-tgfb-signaling-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-neurotrophic-factor-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-anti-tau-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-microbiome-based-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-senolytic-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-er-stress-upr-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-adult-neurogenesis-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-4r-tauopathy-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-protein-aggregation-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-mitochondrial-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-heat-shock-protein-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-glp-1-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-rna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-anti-tau-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-peptide-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-lysosomal-dysfunction-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-anti-amyloid-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-rna-editing-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-digital-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-events-mds-2026-parkinsons-emerging-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-4d-molecular-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-chelsea-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-ad-exosome-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neubase-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-appvian-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-vator-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-alectos-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-sangamo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-crispr-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neuromito-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-inception-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-yumanity-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-monte-rosa-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-t3d-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neuexo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-cyclo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-cynata-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-lyterian-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-denali-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-evox-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-cerevel-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-trefoil-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pd-digital-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pd-exosome-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-click-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pd-rna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-ventus-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-rodin-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-arvinas-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pear-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-axsome-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-synaptic-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-synchronicity-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-ad-rna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-encoded-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-axial-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-lexeo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-vtv-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neteo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-stoke-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-heqix-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-karuna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-fulcrum-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-iduna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-lysoway-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-koneqia-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-ad-digital-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-ifm-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-voyager-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-alterity-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-pinteon-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-blue-rock-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-spark-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-muna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-finch-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-aleza-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-prevail-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-paxos-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-capricor-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-sage-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-convelo-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neumora-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-spin-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-amyl-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-cytochrome-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-brainstorm-cell-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-organizations-denali-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-institutions-denali-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-institutions-aleza-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'THERAPEUTICS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-growth-factor-therapies-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'GROWTH' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-growth-factor-therapies","link_type":"mentions","strength":0.5,"evidence":"Entity 'GROWTH' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-growth-factors","link_type":"mentions","strength":0.5,"evidence":"Entity 'GROWTH' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-investment-growth-factor-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'GROWTH' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-growth-factor-signaling-4r-tauopathies","link_type":"mentions","strength":0.5,"evidence":"Entity 'GROWTH' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-therapeutics-hedgehog-signaling-modulators-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'HEDGEHOG' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-ideas-payload-hedgehog-signaling-modulation-therapy","link_type":"mentions","strength":0.5,"evidence":"Entity 'HEDGEHOG' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-hedgehog-signaling-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'HEDGEHOG' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-hedgehog-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'HEDGEHOG' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-hedgehog-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'HEDGEHOG' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-clinical-trials-pain-autonomic-symptoms-parkinsonism-nct05748028","link_type":"mentions","strength":0.5,"evidence":"Entity 'PAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-clinical-trials-serotonin-pet-pain-pd-nct06008704","link_type":"mentions","strength":0.5,"evidence":"Entity 'PAIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-clinical-trials-blarcamesine-axon","link_type":"mentions","strength":0.5,"evidence":"Entity 'AXON' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-parkin-protein","link_type":"mentions","strength":0.5,"evidence":"Entity 'PARKIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-map2","link_type":"mentions","strength":0.5,"evidence":"Entity 'MAP2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-models-lrrk2-g2019s-transgenic-mouse-model","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRRK2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-pax2","link_type":"mentions","strength":0.5,"evidence":"Entity 'PAX2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-foxa2","link_type":"mentions","strength":0.5,"evidence":"Entity 'FOXA2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-ascl1","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASCL1' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-fgf8","link_type":"mentions","strength":0.5,"evidence":"Entity 'FGF8' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-ptbp1","link_type":"mentions","strength":0.5,"evidence":"Entity 'PTBP1' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-scn9a","link_type":"mentions","strength":0.5,"evidence":"Entity 'SCN9A' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-dysf","link_type":"mentions","strength":0.5,"evidence":"Entity 'DYSF' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-lmx1a","link_type":"mentions","strength":0.5,"evidence":"Entity 'LMX1A' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-palb2","link_type":"mentions","strength":0.5,"evidence":"Entity 'PALB2' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-syna","link_type":"mentions","strength":0.5,"evidence":"Entity 'SYNA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-neurod1","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROD1' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-genes-map6","link_type":"mentions","strength":0.5,"evidence":"Entity 'MAP6' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-mlcs-dysfunction-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-mitochondria-lysosome-contact-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-hypotheses-mlsm-axis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-mlcs-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-mitochondria-lysosome-contact-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-mitochondria-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-mitochondria-lysosome-contact-sites","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-mitochondria","link_type":"mentions","strength":0.5,"evidence":"Entity 'MITOCHONDRIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-circuits-alzheimer-hippocampal-circuit","link_type":"mentions","strength":0.5,"evidence":"Entity 'ALZHEIMER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-institutions-alzheimer-europe","link_type":"mentions","strength":0.5,"evidence":"Entity 'ALZHEIMER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"mentions","strength":0.5,"evidence":"Entity 'ALZHEIMER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-circuits-parkinson-basal-ganglia-circuit","link_type":"mentions","strength":0.5,"evidence":"Entity 'PARKINSON' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-neurodegeneration-parkinson","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dementia-with-lewy-bodies-astrocytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-argyrophilic-grain-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-hepatic-encephalopathy","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-homeostasis","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-als","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-astrocytes-wilson-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-astrocytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-mptp-induced-dopaminergic-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MPTP' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-mptp-parkinson-model","link_type":"mentions","strength":0.5,"evidence":"Entity 'MPTP' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-models-mptp-mouse-model-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'MPTP' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-dentatorubral-pallidoluysian-atrophy-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-wilson-disease-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-neurons-hierarchy","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-normal-pressure-hydrocephalus-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-prion-disease-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-lysosomal-storage-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-spinocerebellar-ataxia-type-3-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-viral-entry-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURONS' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-basal-radial-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-neural-crest-derived-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-bergmann-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-ng2-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-muller-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-satellite-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-radial-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-outer-radial-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-nigral-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-enteric-glia","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLIA' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-spinal-interneurons-motor-neuron-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-cerebellar-purkinje-cells-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-pedunculopontine-nucleus-cholinergic-neurons-in-lewy-body-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-pedunculopontine-nucleus-neurons-lewy-body-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-cerebellar-neurons-creutzfeldt-jakob-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-cerebellar-granule-cells-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-ivns1abp-mutation-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-cross-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-cerebrovascular-disease","link_type":"mentions","strength":0.5,"evidence":"Entity 'DISEASE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-glutamate-receptor-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-gad-glutamate-decarboxylase-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-glutamate-transporter-neurons","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-glutamate-transport","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-glutamate-excitotoxicity","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-glutamate-excitotoxicity-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-glutamate-signaling","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-biomarkers-glutamate-excitotoxicity-biomarker","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-glutamate","link_type":"mentions","strength":0.5,"evidence":"Entity 'GLUTAMATE' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-reactive-astrocytes-a2","link_type":"mentions","strength":0.5,"evidence":"Entity 'REACTIVE ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-reactive-astrocytes-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'REACTIVE ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-reactive-astrocytes-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Entity 'REACTIVE ASTROCYTES' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-aging-associated-astrocytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-aging-oligodendrocytes","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-cell-types-aging-microglia","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-aging-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-aging-to-ad-switch-trigger","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Entity 'AGING' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-axonal-transport","link_type":"mentions","strength":0.5,"evidence":"Entity 'AXONAL TRANSPORT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-ad-neuroinflammation-microglia-pathway","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROINFLAMMATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-cbs-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROINFLAMMATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-cbd-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROINFLAMMATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-pd-neuroinflammation","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROINFLAMMATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-diagnostics-cbs-psp-neuroinflammation-pet","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEUROINFLAMMATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-liver-brain-neurodegeneration-axis","link_type":"mentions","strength":0.5,"evidence":"Entity 'LIVER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-liver-brain-axis-bbb-protection","link_type":"mentions","strength":0.5,"evidence":"Entity 'LIVER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-lxr-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'LIVER' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'CHROMATIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling-epigenetic-therapy-neurodegeneration-synthesis","link_type":"mentions","strength":0.5,"evidence":"Entity 'CHROMATIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-chromatin-remodeling","link_type":"mentions","strength":0.5,"evidence":"Entity 'CHROMATIN' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-mechanisms-fibroblast-growth-factor-signaling-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Entity 'FIBROBLAST' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-p300-bci","link_type":"mentions","strength":0.5,"evidence":"Entity 'P300' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-technologies-spect","link_type":"mentions","strength":0.5,"evidence":"Entity 'SPECT' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-biomarkers-neuron-specific-enolase-nse","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURON' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-companies-neuron-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Entity 'NEURON' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-entities-dna-methylation","link_type":"mentions","strength":0.5,"evidence":"Entity 'DNA METHYLATION' mentioned in hypothesis description/evidence"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-clinical-trials-beacon-study-nct03860857","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-clinical-trials-olfactory-mucosa-early-neurodegeneration-nct06846658","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-clinical-trials-gut-brain-axis-neurodegeneration-nct05934188","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-clinical-trials-swedish-biofinder-2-psp-nct03174938","link_type":"related","strength":0.6,"evidence":"Disease page related to hypothesis disease: neurodegeneration"},{"source_artifact_id":"wiki-genes-prpf3","link_type":"related","strength":0.5,"evidence":"Wiki title word 'FACTOR' found in hypothesis pathway"},{"source_artifact_id":"wiki-genes-sdhaf2","link_type":"related","strength":0.5,"evidence":"Wiki title word 'FACTOR' found in hypothesis pathway"},{"source_artifact_id":"wiki-genes-prpf6","link_type":"related","strength":0.5,"evidence":"Wiki title word 'FACTOR' found in hypothesis pathway"},{"source_artifact_id":"wiki-genes-pafah1b1","link_type":"related","strength":0.5,"evidence":"Wiki title word 'FACTOR' found in hypothesis pathway"},{"source_artifact_id":"wiki-genes-tfap4","link_type":"related","strength":0.5,"evidence":"Wiki title word 'TRANSCRIPTION' found in hypothesis pathway"},{"source_artifact_id":"wiki-genes-arhgef28","link_type":"related","strength":0.5,"evidence":"Wiki title word 'FACTOR' found in hypothesis pathway"},{"source_artifact_id":"wiki-mechanisms-substantia-nigra-selective-vulnerability-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dat-dysfunction-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopaminergic-neuron-vulnerability","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-pd-dopamine-metabolism","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-trace-amine-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-mesolimbic-dopamine-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-complement-system-activation-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-epigenetics-ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-protein-quality-control-network","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-quality-control-network-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-htt-huntingtin-hd-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopaminergic-vulnerability","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-neurotrophic-factor-signaling-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-complement-activation-cbd","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-gene-mechanism-therapy-causal-chains","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-cbs-pyroptosis-inflammasome-activation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-transcription-regulation-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-mlcs-parkinsons-ipsc-methods","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-cbs-psp-genetic-architecture","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopaminergic-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-lrrk2-kinase-endolysosomal-dysfunction-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-nonfluent-agrammatic-ppa-mechanisms","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopamine-metabolism","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-pre-symptomatic-conversion-als","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-amyloid-beta-trans-synaptic-spread-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-syk-kinase-microglial-activation-alzheimers","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-tau-oligodendrocyte-methylation-ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-neurotrophic-factor-signaling","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-network-functional-connectivity-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-nlrp3-inflammasome-activation-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-psp-pyroptosis-inflammasome-activation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-mds-2026-pd-genetic-molecular-mechanisms","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-cr1-complement-synaptic-pruning-ad-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dian","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-pd-genetic-penetrance","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-semantic-variant-ftd-mechanisms","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-psp-neurotrophic-factor-dysfunction","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopamine-biosynthesis-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-proteostasis-network","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopamine-oxidation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-gba-parkinson-risk","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-cbs-network-spreading","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopamine-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-aav-gene-therapy-vectors-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-tau-network-propagation-hypothesis","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-gdnf-neurotrophic-signaling-pathway","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-proteostasis-network-comparison","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-transcription-regulation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-fus-als-ftd-causal-chain","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-bdnf-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-epigenetics-psp","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-behavioral-variant-ftd-mechanisms","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-growth-factor-signaling-4r-tauopathies","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-neurotrophic-factor-decline","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-non-dopaminergic-neurotransmitter-degeneration-parkinsons","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-syk-microglial-activation-alzheimers","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-psp-brain-network-connectivity","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-fibroblast-growth-factor-signaling-neurodegeneration","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-c9orf72-als-network","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-network-pharmacology-neurodegeneration-synthesis","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-lrrk2-14-3-3-interaction-network","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-network-oscillation-dysfunction","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-microglia-activation","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-4r-tauopathy-genetic-comparison","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dopamine-signaling","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-brain-network-connectivity-psp","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-dj1-pten-p53-network","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-mechanisms-neural-network-dysfunction-alzheimers","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"wiki-cell-types-telencephalon-development","link_type":"related","strength":0.55,"evidence":"Cell type Telencephalon Development mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-supraoptic-vasopressin-neurons-neurodegeneration","link_type":"related","strength":0.55,"evidence":"Cell type Supraoptic Vasopressin Neurons Neurodegeneration mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-spinal-cord-interneurons-chronic-pain","link_type":"related","strength":0.55,"evidence":"Cell type spinal-cord-interneurons-chronic-pain mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-hypothalamic-melanocortin-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Hypothalamic Melanocortin Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-hippocampal-ca3-pyramidal-neurons-parkinsons","link_type":"related","strength":0.55,"evidence":"Cell type hippocampal-ca3-pyramidal-neurons-parkinsons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-psd95-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Psd95 Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-subicular-neurons","link_type":"related","strength":0.55,"evidence":"Cell type subicular-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-spinothalamic-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Spinothalamic Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-cannabinoid-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Cannabinoid Receptor Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-adenosine-a3-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Adenosine A3 Receptor Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-medullary-rapth-magnus-pain","link_type":"related","strength":0.55,"evidence":"Cell type medullary-rapth-magnus-pain mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-layer-3-neurons","link_type":"related","strength":0.55,"evidence":"Cell type layer-3-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-claustrum-in-alzheimers-disease","link_type":"related","strength":0.55,"evidence":"Cell type Claustrum-in-Alzheimers-Disease mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-dopa-decarboxylase-neurons","link_type":"related","strength":0.55,"evidence":"Cell type dopa-decarboxylase-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-vasopressin-v1a-neurons","link_type":"related","strength":0.55,"evidence":"Cell type vasopressin-v1a-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-medium-spiny-neurons-huntington-disease","link_type":"related","strength":0.55,"evidence":"Cell type medium-spiny-neurons-huntington-disease mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-acc-chronic-pain","link_type":"related","strength":0.55,"evidence":"Cell type acc-chronic-pain mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-pituitary-somatotrophs-neurodegeneration","link_type":"related","strength":0.55,"evidence":"Cell type Pituitary Somatotrophs Neurodegeneration mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-interpeduncular-nucleus-in-parkinsons-disease","link_type":"related","strength":0.55,"evidence":"Cell type Interpeduncular-Nucleus-in-Parkinsons-Disease mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-histamine-h3-heteroreceptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type histamine-h3-heteroreceptor-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-myelin-forming-cells","link_type":"related","strength":0.55,"evidence":"Cell type myelin-forming-cells mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-glutamate-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Glutamate Receptor Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-dopamine-d1-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type dopamine-d1-receptor-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-blood-brain-barrier-endothelial-cells","link_type":"related","strength":0.55,"evidence":"Cell type blood-brain-barrier-endothelial-cells mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-catecholaminergic-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Catecholaminergic Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-arterial-endothelial-cells-brain","link_type":"related","strength":0.55,"evidence":"Cell type arterial-endothelial-cells-brain mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-voltage-gated-calcium-channel-neurons","link_type":"related","strength":0.55,"evidence":"Cell type voltage-gated-calcium-channel-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-choroid-plexus-in-alzheimers-disease","link_type":"related","strength":0.55,"evidence":"Cell type Choroid-Plexus-in-Alzheimers-Disease mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-retinal-amacrine-cells-parkinsons-disease","link_type":"related","strength":0.55,"evidence":"Cell type retinal-amacrine-cells-parkinsons-disease mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-sigma-1-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type sigma-1-receptor-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-serotonergic-raphe-neurons","link_type":"related","strength":0.55,"evidence":"Cell type serotonergic-raphe-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-reward","link_type":"related","strength":0.55,"evidence":"Cell type ventral-tegmental-area-reward mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-adult-neural-stem-cells","link_type":"related","strength":0.55,"evidence":"Cell type adult-neural-stem-cells mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-npy-y1-receptor-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Npy Y1 Receptor Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-deep-cerebellar-nuclei-in-ataxia","link_type":"related","strength":0.55,"evidence":"Cell type Deep-Cerebellar-Nuclei-in-Ataxia mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-nucleus-incertus-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Nucleus Incertus Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-cortical-pyramidal-layer5","link_type":"related","strength":0.55,"evidence":"Cell type cortical-pyramidal-layer5 mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-circadian-neurons-in-neurodegeneration","link_type":"related","strength":0.55,"evidence":"Cell type Circadian-Neurons-in-Neurodegeneration mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-lateral-hypothalamus","link_type":"related","strength":0.55,"evidence":"Cell type Lateral Hypothalamus mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-enteric-nervous-system-expanded","link_type":"related","strength":0.55,"evidence":"Cell type enteric-nervous-system-expanded mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-tyrosine-hydroxylase-th-neurons","link_type":"related","strength":0.55,"evidence":"Cell type Tyrosine Hydroxylase Th Neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-pontine-nucleus-neurons","link_type":"related","strength":0.55,"evidence":"Cell type pontine-nucleus-neurons mentioned in hypothesis"},{"source_artifact_id":"wiki-cell-types-cerebellar-granule-cells","link_type":"related","strength":0.55,"evidence":"Cell type Cerebellar Granule Cells mentioned in hypothesis"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-dopaminergic-neurons","link_type":"mentions","strength":0.65,"evidence":"Title match: Dopaminergic Neurons"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.65,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-mechanisms-genetics","link_type":"mentions","strength":0.65,"evidence":"Title match: genetics"},{"source_artifact_id":"wiki-clinical-trials","link_type":"mentions","strength":0.65,"evidence":"Title match: Clinical Trials"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-parkinsons-disease","link_type":"mentions","strength":0.65,"evidence":"Title match: Parkinson's Disease"},{"source_artifact_id":"wiki-cell-types-motor-neurons","link_type":"mentions","strength":0.65,"evidence":"Title match: Motor Neurons"},{"source_artifact_id":"wiki-technologies-optogenetics","link_type":"mentions","strength":0.65,"evidence":"Title match: Optogenetics"},{"source_artifact_id":"wiki-diseases-amyotrophic-lateral-sclerosis","link_type":"mentions","strength":0.65,"evidence":"Title match: Amyotrophic Lateral Sclerosis"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"mentions","strength":0.65,"evidence":"Title match: Alzheimer's Disease"},{"source_artifact_id":"wiki-cell-types-substantia-nigra","link_type":"mentions","strength":0.65,"evidence":"Title match: Substantia Nigra Neurons"},{"source_artifact_id":"wiki-brain-regions","link_type":"mentions","strength":0.65,"evidence":"Title match: Brain Regions"},{"source_artifact_id":"wiki-diseases-huntingtons","link_type":"mentions","strength":0.65,"evidence":"Title match: Huntington's Disease"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-technologies","link_type":"mentions","strength":0.65,"evidence":"Title match: Technologies"},{"source_artifact_id":"wiki-cell-types","link_type":"mentions","strength":0.65,"evidence":"Title match: Cell Types"},{"source_artifact_id":"wiki-cell-types-cholinergic-neurons","link_type":"mentions","strength":0.65,"evidence":"Title match: Cholinergic Neurons"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-glutamatergic-neurons","link_type":"mentions","strength":0.65,"evidence":"Title match: Glutamatergic Neurons"},{"source_artifact_id":"wiki-therapeutics","link_type":"mentions","strength":0.65,"evidence":"Title match: Therapeutics"},{"source_artifact_id":"open_question-8d98953b-229f-4da7-b50b-3bbf3f49a2b4","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-98b3e538-39c3-45df-9d8f-e5918d3801ca","link_type":"bears_on_question","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-5ed8ee43-6276-4d8b-b863-f5b32c29d88e","link_type":"bears_on_question","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-517e4dcb-13db-4894-b8dc-38f239b35d9a","link_type":"candidate_answer","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-e57ded60-0aa8-4bdd-9a0c-f1065c6a0c63","link_type":"candidate_answer","strength":0.75,"evidence":"{\"confidence\": 0.75, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-7d03ee55-88f4-4875-acc1-65300b9f07fa","link_type":"partial_answer_for","strength":0.48,"evidence":"{\"confidence\": 0.48, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"hypothesis-h-9d22b570","is_canonical":true,"supersede_chain":["hypothesis-h-9d22b570"]}