{"artifact":{"id":"hypothesis-h-da9af6a77a","artifact_type":"hypothesis","entity_ids":"[]","title":"NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic Neuron Survival in Parkinson's Disease Models","quality_score":0.79,"created_by":"hypothesis_page_handler","provenance_chain":"[]","content_hash":"066effcd548f021186fba06fbdd8a394797f4403dce890a80ae8c0afecbf69b7","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T15:33:42.964883"},"description":"## Mechanistic Overview\nNMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic Neuron Survival in Parkinson's Disease Models starts from the claim that modulating SIRT1/NAD+ axis within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: \"**Molecular Mechanism and Rationale** The proposed therapeutic mechanism centers on the restoration of the NAD+/SIRT1 epigenetic regulatory axis in dopaminergic neurons of t","hypothesis_id":"h-da9af6a77a","_schema_version":1},"created_at":"2026-04-28T08:33:42.965001-07:00","updated_at":"2026-04-28T08:33:42.965001-07:00","version_number":3,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c1a4019b-8429-4140-9b34-c6e99ea1aa57","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"hypothesis_page_handler"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[{"source_artifact_id":"bench_pd_dopaminergic_expression_signature_v1","link_type":"related","strength":0.75,"evidence":"PD Dopaminergic Neuron Expression Signature benchmark seeded to evaluate hypotheses/gaps related to hypothesis-h-da9af6a77a (forge:benchmark_seed_2026-04-28)."}],"current_artifact_id":"hypothesis-h-da9af6a77a","is_canonical":true,"supersede_chain":["hypothesis-h-da9af6a77a"]}