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TFEB"},{"target_artifact_id":"wiki-proteins-alpha-synuclein","link_type":"related","strength":0.4,"evidence":"KG bridge: ALPHA-SYNUCLEIN ↔ TFEB"},{"target_artifact_id":"wiki-institutions-packard-center-als","link_type":"related","strength":0.4,"evidence":"KG bridge: ALS ↔ TFEB"},{"target_artifact_id":"wiki-genes-als4","link_type":"related","strength":0.4,"evidence":"KG bridge: ALS4 ↔ TFEB"},{"target_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"related","strength":0.4,"evidence":"KG bridge: ALZHEIMER ↔ TFEB"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.4,"evidence":"KG bridge: ALZHEIMER'S DISEASE ↔ TFEB"},{"target_artifact_id":"wiki-genes-ambra1","link_type":"related","strength":0.4,"evidence":"KG bridge: AMBRA1 ↔ TFEB"},{"target_artifact_id":"wiki-TFEB","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene TFEB"},{"target_artifact_id":"wiki-genes-tfeb","link_type":"targets","strength":0.9,"evidence":null},{"target_artifact_id":"wiki-cell-types-cochlear-hair-cells-aging","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: cell-types-cochlear-hair-cells-aging --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-experiments-selective-neuronal-vulnerability-aging","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: experiments-selective-neuronal-vulnerability-aging --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-mechanisms-cellular-senescence-brain-aging","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: mechanisms-cellular-senescence-brain-aging --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-mechanisms-epigenetic-clocks-brain-aging","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: mechanisms-epigenetic-clocks-brain-aging --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-diseases-als","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: diseases-als --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-cell-types-hippocampal-ca3-neurons-alzheimer","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: cell-types-hippocampal-ca3-neurons-alzheimer --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-cell-types-microglia-neurodegeneration-alzheimer","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: cell-types-microglia-neurodegeneration-alzheimer --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-researchers-alois-alzheimer","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: researchers-alois-alzheimer --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-entities-ampk","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: entities-ampk --activates--> TFEB (hypothesis 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mechanisms-apoptosis --associated_with--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-proteins-app","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: proteins-app --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-genes-aqp4","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: genes-aqp4 --co_discussed--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-genes-ar","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: genes-ar --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-genes-arc","link_type":"see_also","strength":0.5,"evidence":"Reverse: KG edge: genes-arc --activates--> TFEB (hypothesis target)"},{"target_artifact_id":"wiki-proteins-tfeb","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene TFEB discussed in wiki page"},{"target_artifact_id":"wiki-genes-tfeb","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene TFEB discussed in wiki page"},{"target_artifact_id":"wiki-entities-tfeb","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene TFEB discussed in wiki page"}],"incoming_links":[{"source_artifact_id":"experiment-exp-6c42097c-1042-4686-bacf-d5adc29cd868","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-eb6c3b7d-b813-471c-90bc-79b65b7b6dde","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-41a0b4b1-9406-4ed5-b496-fb18149232f6","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb","link_type":"related","strength":1.0,"evidence":"Shared entity overlap (Jaccard=1.00)"},{"source_artifact_id":"experiment-exp-2141f24c-6948-4c8b-a156-22051d521fd1","link_type":"related","strength":1.0,"evidence":"Shared entity overlap 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mentioned 4x in wiki/therapeutics-ambroxol-parkinsons"},{"source_artifact_id":"wiki-therapeutics-mitochondrial-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/therapeutics-mitochondrial-therapeutics"},{"source_artifact_id":"wiki-therapeutics-anti-tau-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/therapeutics-anti-tau-therapeutics"},{"source_artifact_id":"wiki-investment-peptide-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-peptide-therapeutics"},{"source_artifact_id":"wiki-investment-microbiome-based-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-microbiome-based-therapeutics"},{"source_artifact_id":"wiki-investment-senolytic-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-senolytic-therapeutics"},{"source_artifact_id":"wiki-investment-er-stress-upr-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-er-stress-upr-therapeutics"},{"source_artifact_id":"wiki-investment-adult-neurogenesis-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-adult-neurogenesis-therapeutics"},{"source_artifact_id":"wiki-investment-4r-tauopathy-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-4r-tauopathy-therapeutics"},{"source_artifact_id":"wiki-investment-protein-aggregation-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-protein-aggregation-therapeutics"},{"source_artifact_id":"wiki-investment-heat-shock-protein-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-heat-shock-protein-therapeutics"},{"source_artifact_id":"wiki-investment-mitochondrial-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-mitochondrial-therapeutics"},{"source_artifact_id":"wiki-investment-rna-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-rna-therapeutics"},{"source_artifact_id":"wiki-investment-anti-tau-therapeutics","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 2x in wiki/investment-anti-tau-therapeutics"},{"source_artifact_id":"wiki-cell-types-tuberomammillary-nucleus-expanded","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-tuberomammillary-nucleus-expanded"},{"source_artifact_id":"wiki-cell-types-interstitial-nucleus-of-cajal","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-interstitial-nucleus-of-cajal"},{"source_artifact_id":"wiki-cell-types-spinal-cord-lamina-x","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-spinal-cord-lamina-x"},{"source_artifact_id":"wiki-cell-types-inferior-colliculus-localization","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-inferior-colliculus-localization"},{"source_artifact_id":"wiki-cell-types-ventral-pallidum-neurons-motivation","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-ventral-pallidum-neurons-motivation"},{"source_artifact_id":"wiki-cell-types-reticular-thalamic-nucleus-gabaergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-reticular-thalamic-nucleus-gabaergic"},{"source_artifact_id":"wiki-cell-types-medial-septal-cholinergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-medial-septal-cholinergic"},{"source_artifact_id":"wiki-cell-types-tuberomammillary-histaminergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-tuberomammillary-histaminergic"},{"source_artifact_id":"wiki-cell-types-cortical-chandelier-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-cortical-chandelier-cells"},{"source_artifact_id":"wiki-cell-types-laterodorsal-tegmental-nucleus-gabaergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-laterodorsal-tegmental-nucleus-gabaergic"},{"source_artifact_id":"wiki-cell-types-preoptic-area-gaehrens","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-preoptic-area-gaehrens"},{"source_artifact_id":"wiki-cell-types-striatal-horizontal-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-striatal-horizontal-cells"},{"source_artifact_id":"wiki-cell-types-lateral-pericentral-nucleus-inferior-colliculus","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-lateral-pericentral-nucleus-inferior-colliculus"},{"source_artifact_id":"wiki-cell-types-horizonal-diagonal-band","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-horizonal-diagonal-band"},{"source_artifact_id":"wiki-cell-types-globus-pallidus-internal-segment-gabaergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-globus-pallidus-internal-segment-gabaergic"},{"source_artifact_id":"wiki-cell-types-gaba-c-receptor-neurons","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-gaba-c-receptor-neurons"},{"source_artifact_id":"wiki-cell-types-lateral-preoptic-area","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-lateral-preoptic-area"},{"source_artifact_id":"wiki-cell-types-hippocampal-axo-axonic-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-hippocampal-axo-axonic-cells"},{"source_artifact_id":"wiki-cell-types-cochlear-nuclei-auditory","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-cochlear-nuclei-auditory"},{"source_artifact_id":"wiki-cell-types-reticularis-pontis-oralis","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-reticularis-pontis-oralis"},{"source_artifact_id":"wiki-cell-types-laterodorsal-tegmental","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-laterodorsal-tegmental"},{"source_artifact_id":"wiki-cell-types-globus-pallidus-externus","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-globus-pallidus-externus"},{"source_artifact_id":"wiki-cell-types-lateral-lemniscus","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-lateral-lemniscus"},{"source_artifact_id":"wiki-cell-types-ventral-pallidum-reward","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-ventral-pallidum-reward"},{"source_artifact_id":"wiki-cell-types-olfactory-bulb-short-axon-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-olfactory-bulb-short-axon-cells"},{"source_artifact_id":"wiki-cell-types-medial-geniculate","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-medial-geniculate"},{"source_artifact_id":"wiki-cell-types-habenular-commissure-fibers","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-habenular-commissure-fibers"},{"source_artifact_id":"wiki-cell-types-horizontal-cells-retina","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-horizontal-cells-retina"},{"source_artifact_id":"wiki-cell-types-spinal-lamina-ii-substantia-gelatinosa","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-spinal-lamina-ii-substantia-gelatinosa"},{"source_artifact_id":"wiki-cell-types-purkinje-cell-axonal-terminals","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-purkinje-cell-axonal-terminals"},{"source_artifact_id":"wiki-cell-types-median-raphe","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-median-raphe"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-gabaergic","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-ventral-tegmental-area-gabaergic"},{"source_artifact_id":"wiki-cell-types-cerebellar-purkinje-cells-motor","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-cerebellar-purkinje-cells-motor"},{"source_artifact_id":"wiki-cell-types-main-olfactory-bulb","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-main-olfactory-bulb"},{"source_artifact_id":"wiki-cell-types-ventral-tegmental-area-expanded-v2","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-ventral-tegmental-area-expanded-v2"},{"source_artifact_id":"wiki-cell-types-ventral-pallidum","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-ventral-pallidum"},{"source_artifact_id":"wiki-cell-types-gaba-receptors-neurons","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-gaba-receptors-neurons"},{"source_artifact_id":"wiki-cell-types-triangular-nucleus-septern","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-triangular-nucleus-septern"},{"source_artifact_id":"wiki-cell-types-renshaw-cells-inhibition","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-renshaw-cells-inhibition"},{"source_artifact_id":"wiki-cell-types-golgi-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-golgi-cells"},{"source_artifact_id":"wiki-cell-types-laterodorsal-tegmental-nucleus-expanded","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-laterodorsal-tegmental-nucleus-expanded"},{"source_artifact_id":"wiki-cell-types-hippocampal-pv-interneurons","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-hippocampal-pv-interneurons"},{"source_artifact_id":"wiki-cell-types-flocculus","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-flocculus"},{"source_artifact_id":"wiki-cell-types-horizonal-limb-diagonal-band","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-horizonal-limb-diagonal-band"},{"source_artifact_id":"wiki-cell-types-cortical-bipolar-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-cortical-bipolar-cells"},{"source_artifact_id":"wiki-cell-types-hypothalamic-sleep-active","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-hypothalamic-sleep-active"},{"source_artifact_id":"wiki-cell-types-habenula-mood-reward","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-habenula-mood-reward"},{"source_artifact_id":"wiki-cell-types-striatal-parvalbumin-interneurons","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-striatal-parvalbumin-interneurons"},{"source_artifact_id":"wiki-cell-types-cortical-basket-cells","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-cortical-basket-cells"},{"source_artifact_id":"wiki-cell-types-wernickes-area","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-wernickes-area"},{"source_artifact_id":"wiki-cell-types-intercalated-nucleus-amygdala-expanded","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in wiki/cell-types-intercalated-nucleus-amygdala-expanded"},{"source_artifact_id":"wiki-cell-types-pars-reticularis-nigral","link_type":"mentions","strength":0.6,"evidence":"Content: TFEB mentioned 4x in 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analysis"},{"source_artifact_id":"wiki-arsacs","link_type":"related","strength":0.45,"evidence":"Domain-level link via neurodegeneration analysis"},{"source_artifact_id":"wiki-arsb","link_type":"related","strength":0.45,"evidence":"Domain-level link via neurodegeneration analysis"},{"source_artifact_id":"wiki-arx","link_type":"related","strength":0.45,"evidence":"Domain-level link via neurodegeneration analysis"},{"source_artifact_id":"wiki-meta-tags","link_type":"related","strength":0.45,"evidence":"Domain-level link via neurodegeneration analysis"},{"source_artifact_id":"wiki-genes-deptor","link_type":"related","strength":0.6,"evidence":"KG edge: DEPTOR connects to TFEB"},{"source_artifact_id":"wiki-genes-cfh","link_type":"related","strength":0.6,"evidence":"KG edge: CFH connects to TFEB"},{"source_artifact_id":"wiki-genes-nlrx1","link_type":"related","strength":0.6,"evidence":"KG edge: NLRX1 connects to 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ALPHA-SYNUCLEIN ↔ TFEB"},{"source_artifact_id":"wiki-institutions-packard-center-als","link_type":"related","strength":0.4,"evidence":"KG bridge: ALS ↔ TFEB"},{"source_artifact_id":"wiki-genes-als4","link_type":"related","strength":0.4,"evidence":"KG bridge: ALS4 ↔ TFEB"},{"source_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"related","strength":0.4,"evidence":"KG bridge: ALZHEIMER ↔ TFEB"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.4,"evidence":"KG bridge: ALZHEIMER'S DISEASE ↔ TFEB"},{"source_artifact_id":"wiki-genes-ambra1","link_type":"related","strength":0.4,"evidence":"KG bridge: AMBRA1 ↔ TFEB"},{"source_artifact_id":"wiki-diseases-lysosomal-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 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