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granule"},{"source_artifact_id":"wiki-genes-pfn1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-trpm8","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-celf1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-trim24","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-rpl21","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-hspbap1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-gemin4","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-elavl4","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-srsf1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-cdk11a","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-dnajc4","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-hsp90aa1","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-als9","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-atg12","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-prpf31","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-dnajc26","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-rnasek","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-morc3","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Stress granule"},{"source_artifact_id":"wiki-genes-hnrnpg","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene G3BP1"},{"source_artifact_id":"wiki-genes-rpl30","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene G3BP1"},{"source_artifact_id":"wiki-genes-lsml1","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene G3BP1"},{"source_artifact_id":"wiki-genes-hnrnpm","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene G3BP1"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease: neurodegeneration"},{"source_artifact_id":"experiment-exp-wiki-experiments-c9orf72-hexanucleotide-repeat-mechanism","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-prion-pre-symptomatic-detection","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-c9orf72-phenotype-divergence-als-ftd","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"experiment-exp-debate-7c7a8ed89fd3","link_type":"supports","strength":0.8,"evidence":"Experiment designed to test this hypothesis"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Disease match: neurodegeneration"},{"source_artifact_id":"wiki-g3bp1","link_type":"mentions","strength":0.8,"evidence":"Shared entity_id: G3BP1"},{"source_artifact_id":"open_question-5d89bdd4-b6d5-4dbc-91b5-00e92d729614","link_type":"bears_on_question","strength":0.4,"evidence":"{\"confidence\": 0.4, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-1aa28c4e-6a34-4330-bf1c-914119cb08d7","link_type":"candidate_answer","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-77868f83-fea2-487d-a259-6a39d315552d","link_type":"candidate_answer","strength":0.92,"evidence":"{\"confidence\": 0.92, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"open_question-55b07b98-a397-4f21-97c2-0a5a2d6c72b5","link_type":"partial_answer_for","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"source_artifact_id":"paper-32213321","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 32213321: G3BP1 knockout reduces neuroinflammation and improves outcomes after CNS injury"},{"source_artifact_id":"paper-31776345","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 31776345: G3BP1 directly activates cGAS within stress granules to amplify innate immune signaling"},{"source_artifact_id":"paper-33219229","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 33219229: Stress granule persistence drives neuroinflammation via STING pathway in ALS/FTD models"},{"source_artifact_id":"paper-30078711","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 30078711: G3BP1/2 are essential scaffolds for stress granule assembly via liquid-liquid phase separation"},{"source_artifact_id":"paper-26317470","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 26317470: Pathological stress granule maturation involves liquid-to-solid phase transitions of RNA-binding proteins"},{"source_artifact_id":"paper-31113947","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 31113947: Tau oligomers induce G3BP1-dependent stress granule formation causing translational repression in AD neurons"},{"source_artifact_id":"paper-32302571","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 32302571: G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules."},{"source_artifact_id":"paper-32048886","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 32048886: Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles."},{"source_artifact_id":"paper-36394332","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 36394332: Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage."},{"source_artifact_id":"paper-37100798","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 37100798: Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex."},{"source_artifact_id":"paper-36806943","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 36806943: The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation."},{"source_artifact_id":"paper-41780839","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41780839: Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer."},{"source_artifact_id":"paper-41508039","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41508039: Proteasome inhibition by VR23 enhances autophagic clearance of FUS(P525L)-mediated persistent stress granule in SH-SY5Y cells."},{"source_artifact_id":"paper-39995077","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 39995077: Confirms the role of stress granules as critical cellular structures that can mediate both protective and pathological responses in neurological contexts."},{"source_artifact_id":"paper-41597214","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41597214: Demonstrates how stress granule formation is linked to integrated stress responses and inflammatory cytokine production, consistent with the hypothesis's mechanisms."},{"source_artifact_id":"paper-41808986","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41808986: Highlights the complex protein interactions within stress granules and their role in translation regulation, which aligns with the hypothesis's description of stress granule molecular architecture."},{"source_artifact_id":"paper-41586493","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41586493: Provides direct evidence of targeting G3BP1 as a potential therapeutic strategy, supporting the hypothesis's core mechanistic and therapeutic approach."},{"source_artifact_id":"paper-41931190","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41931190: Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities."},{"source_artifact_id":"paper-41935238","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41935238: Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation."},{"source_artifact_id":"paper-41960678","link_type":"supports","strength":0.7,"evidence":"Evidence from PMID 41960678: Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication."}],"current_artifact_id":"hypothesis-h-ec731b7a","is_canonical":true,"supersede_chain":["hypothesis-h-ec731b7a"]}