{"artifact":{"id":"hypothesis-h-var-18aae53fe9","artifact_type":"hypothesis","entity_ids":"[]","title":"TREM2-ASM Crosstalk in Microglial Lysosomal Senescence","quality_score":0.913761,"created_by":"hypothesis_page_handler","provenance_chain":"[]","content_hash":"cc862f9a3dae376a2870c27733bd4c989ef4b41b759de6dd8d92679475aa8291","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-27T16:04:40.501324"},"description":"## Mechanistic Overview\nTREM2-ASM Crosstalk in Microglial Lysosomal Senescence starts from the claim that modulating SMPD1 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: \"**Molecular Mechanism and Rationale** The TREM2-ASM crosstalk hypothesis centers on the intersection of microglial immunoreceptor signaling and sphingolipid metabolism within the lysosomal compartment. TREM2 (Triggering Receptor Expressed on Myeloid cells","hypothesis_id":"h-var-18aae53fe9","_schema_version":1},"created_at":"2026-04-27T09:04:40.507980-07:00","updated_at":"2026-04-27T09:04:40.507980-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d3e24b67-b401-4d19-96d6-15424ee39e06","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"hypothesis_page_handler"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"hypothesis-h-var-18aae53fe9","is_canonical":true,"supersede_chain":["hypothesis-h-var-18aae53fe9"]}