{"artifact":{"id":"hypothesis-h-var-6612521a02","artifact_type":"hypothesis","entity_ids":"[]","title":"Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease","quality_score":0.950872,"created_by":"hypothesis_page_handler","provenance_chain":"[]","content_hash":"85a8892d21f1c2949ee7b49616a747b72860c87de50e7fe6d8ec84c83aaef528","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-27T16:04:00.013996"},"description":"## Mechanistic Overview\nClosed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: \"**Background and Rationale** Alzheimer's disease (AD) manifests early hippocampal network dysfunction characterized by the progressive loss of gamma oscillations","hypothesis_id":"h-var-6612521a02","_schema_version":1},"created_at":"2026-04-27T09:04:00.021404-07:00","updated_at":"2026-04-27T09:04:00.021404-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"8d5e0147-9793-4202-a9f8-256bae7bdcc6","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"hypothesis_page_handler"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"hypothesis-h-var-6612521a02","is_canonical":true,"supersede_chain":["hypothesis-h-var-6612521a02"]}