{"artifact":{"id":"hypothesis-h-var-b7e4505525","artifact_type":"hypothesis","entity_ids":"[]","title":"Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease","quality_score":0.957822,"created_by":"hypothesis_page_handler","provenance_chain":"[]","content_hash":"24cef12953e90661c2217625570aa6e4a80b4fea123490ea066177a383b8446d","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-27T16:03:58.284740"},"description":"## Mechanistic Overview\nClosed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease starts from the claim that modulating SST within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: \"## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma osc","hypothesis_id":"h-var-b7e4505525","_schema_version":1},"created_at":"2026-04-27T09:03:58.293059-07:00","updated_at":"2026-04-27T09:03:58.293059-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c0df97b6-b692-4af3-97ba-5946aded603d","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"hypothesis_page_handler"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[{"source_artifact_id":"wiki-diseases-alzheimer","link_type":"related","strength":0.9,"evidence":"Curated AD disease page: top-scored SciDEX AD hypothesis"}],"current_artifact_id":"hypothesis-h-var-b7e4505525","is_canonical":true,"supersede_chain":["hypothesis-h-var-b7e4505525"]}