{"artifact":{"id":"open_question-0acb2914-d8d3-4dc5-a7b9-dccf6e59f85b","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"Do different aggregate strains explain clinical heterogeneity within diseases?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"d4329ad58ae1e43de620caed65108c4b09df894aabc4202e28b54a9b6ada858a","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:28:21.335945"},"field_tag":"mechanisms","source_id":"mechanisms-protein-aggregation-comparison","sub_field":"protein-aggregation-comparison","source_kind":"wiki","question_hash":"6c41792ae723874e9c31eff1ca052cbe67c33029eb0cdfb398b943bec9fd594d","question_text":"Do different aggregate strains explain clinical heterogeneity within diseases?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-protein-aggregation-comparison","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:28:21.336108-07:00","updated_at":"2026-04-25T20:28:21.336108-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:28:21.336108-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"3afc067c-be87-4b71-8ab8-36f01321c825","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-protein-aggregation-comparison","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"incoming_links":[],"current_artifact_id":"open_question-0acb2914-d8d3-4dc5-a7b9-dccf6e59f85b","is_canonical":true,"supersede_chain":["open_question-0acb2914-d8d3-4dc5-a7b9-dccf6e59f85b"]}