{"artifact":{"id":"open_question-1d826b32-8dd0-49f5-a5c8-ed8ba7f20332","artifact_type":"open_question","entity_ids":"[\"cell\"]","title":"Why do only some PINK1 mutation carriers develop disease?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"fd32c92117aa919bd38ed5440f8674f670fd449324a613ec85b8fff9cff858a1","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:30.358848"},"field_tag":"cell","source_id":"cell-types-pink1-neurons","sub_field":"types-pink1-neurons","source_kind":"wiki","question_hash":"28a4e40624819f9105fd28c1f7eef4698e9dee4ddaa84ed004847a20d6e02dc2","question_text":"Why do only some PINK1 mutation carriers develop disease?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page cell-types-pink1-neurons","evidence_xref_at":"2026-04-27T14:21:27.043432+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:30.358973-07:00","updated_at":"2026-04-25T20:29:30.358973-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:30.358973-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"294ff5b0-1afd-44a4-9efd-35e109157a9f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-cell-types-pink1-neurons","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"bears_on_question","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"partial_answer_for","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-var-d04a952932","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-91bdb9ad","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"discriminating_experiment","strength":0.85,"evidence":"{\"confidence\": 0.85, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"discriminating_experiment","strength":0.8,"evidence":"{\"confidence\": 0.8, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-tmem106b-genetic-modifier-ftd","link_type":"discriminating_experiment","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-1d826b32-8dd0-49f5-a5c8-ed8ba7f20332","is_canonical":true,"supersede_chain":["open_question-1d826b32-8dd0-49f5-a5c8-ed8ba7f20332"]}