{"artifact":{"id":"open_question-3fc3ac93-718e-418f-a2ea-980d556b8247","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"Are there safety concerns about enhancing synaptic adhesion in a system where over-connectivity could promote excitotoxicity?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"dd8cfdd812129b7aeb0c4194920f77d59e4e92b27fce069bb4a13506ed58a421","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:38.808928"},"field_tag":"mechanisms","source_id":"mechanisms-neurexin-neuroligin-neurodegeneration-modulation","sub_field":"neurexin-neuroligin-neurodegeneration-modulation","source_kind":"wiki","question_hash":"160f3612ff1afc693748ade541bbe995546fdfa81823902b65fe7187bf4a4aab","question_text":"Are there safety concerns about enhancing synaptic adhesion in a system where over-connectivity could promote excitotoxicity?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-neurexin-neuroligin-neurodegeneration-modulation","evidence_xref_at":"2026-04-27T12:41:52.050958+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:38.809065-07:00","updated_at":"2026-04-25T20:29:38.809065-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:38.809065-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"cf8596c5-5bda-4efd-ad9c-984571dbd873","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-neurexin-neuroligin-neurodegeneration-modulation","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"candidate_answer","strength":0.85,"evidence":"{\"confidence\": 0.85, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-a8165b3b","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-early-ad","link_type":"partial_answer_for","strength":0.48,"evidence":"{\"confidence\": 0.48, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-3fc3ac93-718e-418f-a2ea-980d556b8247","is_canonical":true,"supersede_chain":["open_question-3fc3ac93-718e-418f-a2ea-980d556b8247"]}