{"artifact":{"id":"open_question-46fe4d77-2fcd-422e-9a61-7b7531e8204c","artifact_type":"open_question","entity_ids":"[\"researchers\"]","title":"How can Clinical trials, Care research signals be standardized across cohorts and sites without losing disease-stage sensitivity?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"6d8eddbfeb08d5107b07dddd62cea836bfa33868941ac26489e300ac1328e56e","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:37.022700"},"field_tag":"researchers","source_id":"researchers-bengt-winblad","sub_field":"bengt-winblad","source_kind":"wiki","question_hash":"58d0b79f110acf87ef38d62ebe67349d9adda3c712e088626ce4a1c269d8bb80","question_text":"How can Clinical trials, Care research signals be standardized across cohorts and sites without losing disease-stage sensitivity?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page researchers-bengt-winblad","evidence_xref_at":"2026-04-27T13:06:17.838520+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:37.022840-07:00","updated_at":"2026-04-25T20:29:37.022840-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:37.022840-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"39e7a208-afde-4538-a8cc-3d56248fb7b2","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-researchers-bengt-winblad","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-experiment-index","link_type":"bears_on_question","strength":0.72,"evidence":"{\"confidence\": 0.72, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-5557bb06-d381-4a86-b164-12e0dd2cc287","link_type":"partial_answer_for","strength":0.68,"evidence":"{\"confidence\": 0.68, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"discriminating_experiment","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-scoring-methodology","link_type":"candidate_answer","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-57831259-5234-4ae5-8338-b254a8dbed47","link_type":"bears_on_question","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-circadian-vascular-metabolic-syndrome-ad","link_type":"bears_on_question","strength":0.52,"evidence":"{\"confidence\": 0.52, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","link_type":"discriminating_experiment","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-normal-aging-to-ad-transition","link_type":"bears_on_question","strength":0.61,"evidence":"{\"confidence\": 0.61, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"bears_on_question","strength":0.59,"evidence":"{\"confidence\": 0.59, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-46fe4d77-2fcd-422e-9a61-7b7531e8204c","is_canonical":true,"supersede_chain":["open_question-46fe4d77-2fcd-422e-9a61-7b7531e8204c"]}