{"artifact":{"id":"open_question-53b299ad-42ec-4ec0-9a63-362506546741","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"Optimal intervention timing** — When during disease progression should fission be modulated?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"f7c49160399d47ca7f79b26005b29f5cbcaead5c9e004cd002567d8db06e48fb","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:47.116010"},"field_tag":"mechanisms","source_id":"mechanisms-mitochondrial-fission-neurodegeneration","sub_field":"mitochondrial-fission-neurodegeneration","source_kind":"wiki","question_hash":"ec6d27aefcfca36295235d3db6056650ae5173bc2ad44e9c6eb0e10a26e3d5e1","question_text":"Optimal intervention timing** — When during disease progression should fission be modulated?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-mitochondrial-fission-neurodegeneration","evidence_xref_at":"2026-04-27T11:49:08.918462+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:47.116142-07:00","updated_at":"2026-04-25T20:29:47.116142-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:47.116142-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1544149a-214e-4c8e-aa74-0290089e483e","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-mitochondrial-fission-neurodegeneration","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-8bd89d90","link_type":"bears_on_question","strength":0.7,"evidence":"{\"confidence\": 0.7, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"bears_on_question","strength":0.75,"evidence":"{\"confidence\": 0.75, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"bears_on_question","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-cb833ed8","link_type":"bears_on_question","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-a90e2e89","link_type":"bears_on_question","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-aging-h7-prs-aging-convergence","link_type":"bears_on_question","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-a9571dbb","link_type":"bears_on_question","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"bears_on_question","strength":0.7,"evidence":"{\"confidence\": 0.7, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-presymptomatic-grn-carrier-intervention-timing","link_type":"discriminating_experiment","strength":0.85,"evidence":"{\"confidence\": 0.85, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment_proposal-e5b45059-f361-45a3-8ed0-f972ded65df8","link_type":"discriminating_experiment","strength":0.8,"evidence":"{\"confidence\": 0.8, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"discriminating_experiment","strength":0.82,"evidence":"{\"confidence\": 0.82, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-29897aa0-fe95-4809-9f76-24dd8a396b70","link_type":"partial_answer_for","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-prion-pre-symptomatic-detection","link_type":"discriminating_experiment","strength":0.8,"evidence":"{\"confidence\": 0.8, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-normal-aging-to-ad-transition","link_type":"discriminating_experiment","strength":0.88,"evidence":"{\"confidence\": 0.88, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-53b299ad-42ec-4ec0-9a63-362506546741","is_canonical":true,"supersede_chain":["open_question-53b299ad-42ec-4ec0-9a63-362506546741"]}