{"artifact":{"id":"open_question-6989b61e-efe5-4f7f-ab8a-440af0791a22","artifact_type":"open_question","entity_ids":"[\"diseases\"]","title":"How can biomarker-defined subtypes guide personalized treatment?**: Emerging data suggests different therapeutic responses based on biomarker profiles (e.g., tau burden, APOE status). How should treat","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"fa5c8e37567a820a91be3101bbf4856775c20d251f0ceb942fb40b475fd82892","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:25:53.186533"},"field_tag":"diseases","source_id":"diseases-alzheimers-disease","sub_field":"alzheimers-disease","source_kind":"wiki","question_hash":"9e944bedaed89df4fb96271f7a53b08287837fb982e1205985ae8159e35e158e","question_text":"How can biomarker-defined subtypes guide personalized treatment?**: Emerging data suggests different therapeutic responses based on biomarker profiles (e.g., tau burden, APOE status). How should treatment selection be personalized based on molecular subtype?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page diseases-alzheimers-disease","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:25:53.186667-07:00","updated_at":"2026-04-25T20:25:53.186667-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:25:53.186667-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9d4ad619-2a1f-4563-88f7-48a8e64c5e44","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"incoming_links":[],"current_artifact_id":"open_question-6989b61e-efe5-4f7f-ab8a-440af0791a22","is_canonical":true,"supersede_chain":["open_question-6989b61e-efe5-4f7f-ab8a-440af0791a22"]}