{"artifact":{"id":"open_question-6f8bfbff-f48a-41b3-9c07-106ea65350c6","artifact_type":"open_question","entity_ids":"[\"proteins\"]","title":"Therapeutic optimization**: What is the optimal dosing and timing?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"0a4a680c421891ce345ee93077f3b9a511e076415bd655f1d5a15210709689cd","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:43.932112"},"field_tag":"proteins","source_id":"proteins-csf2ra","sub_field":"csf2ra","source_kind":"wiki","question_hash":"857a366636b82ddbe6be5cc039f174e8e406e3fd8a146dc9fc7d1bbb538e8e9c","question_text":"Therapeutic optimization**: What is the optimal dosing and timing?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page proteins-csf2ra","evidence_xref_at":"2026-04-27T12:28:23.063163+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:43.932262-07:00","updated_at":"2026-04-25T20:29:43.932262-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:43.932262-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"df52762f-61c2-44d1-b31e-14ab53dc3919","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-proteins-csf2ra","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"candidate_answer","strength":0.92,"evidence":"{\"confidence\": 0.92, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-debate-d9d4c802fd99","link_type":"discriminating_experiment","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"bears_on_question","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-combination-therapy-sequencing-pd","link_type":"bears_on_question","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-eb97f425-ed39-4f3b-93f8-797ce348761e","link_type":"bears_on_question","strength":0.52,"evidence":"{\"confidence\": 0.52, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"bears_on_question","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment_proposal-e5b45059-f361-45a3-8ed0-f972ded65df8","link_type":"candidate_answer","strength":0.85,"evidence":"{\"confidence\": 0.85, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment_proposal-80535751-ea37-430e-bfbc-672d470c87de","link_type":"candidate_answer","strength":0.85,"evidence":"{\"confidence\": 0.85, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-6f8bfbff-f48a-41b3-9c07-106ea65350c6","is_canonical":true,"supersede_chain":["open_question-6f8bfbff-f48a-41b3-9c07-106ea65350c6"]}