{"artifact":{"id":"open_question-76b9e7e9-562d-4641-8a54-500b9c54a331","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"What is the complete inventory of BACE1 substrates, and how does chronic inhibition affect their function?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"9dd6c1dd0c24f6e67a2f676b060b1c9fa447abf81601529da0ee1378beaaef49","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:45.997405"},"field_tag":"mechanisms","source_id":"mechanisms-app-bace1-fe65-complex","sub_field":"app-bace1-fe65-complex","source_kind":"wiki","question_hash":"b47b46f2dcbee8106601b685ed5688be2ca781de6ae6ee4d0dd6810b0f2a39bb","question_text":"What is the complete inventory of BACE1 substrates, and how does chronic inhibition affect their function?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-app-bace1-fe65-complex","evidence_xref_at":"2026-04-27T12:01:56.959398+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:45.997512-07:00","updated_at":"2026-04-25T20:29:45.997512-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:45.997512-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"38bc43b0-6c8c-48e0-bf16-33d0c2ba562f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-app-bace1-fe65-complex","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"bears_on_question","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"bears_on_question","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-2370b8d3-fa40-4c14-92a7-36bce77cdcd4","link_type":"partial_answer_for","strength":0.72,"evidence":"{\"confidence\": 0.72, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-76b9e7e9-562d-4641-8a54-500b9c54a331","is_canonical":true,"supersede_chain":["open_question-76b9e7e9-562d-4641-8a54-500b9c54a331"]}