{"artifact":{"id":"open_question-ad98882f-ae10-455c-9c22-716a40dc9c2f","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"Population selection**: Should therapy target all PD, only LRRK2 mutation carriers, or all with elevated LRRK2 activity?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"3786badc3239f795f80eea2d4710ed8d660cdc40a12412f30cf0d36f85b93de4","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:35.422721"},"field_tag":"mechanisms","source_id":"mechanisms-lrrk2-kinase-pathway-parkinsons","sub_field":"lrrk2-kinase-pathway-parkinsons","source_kind":"wiki","question_hash":"836e52d73f08e11c9ac0064c2c5ce11a28c18e7eab8f18bcde12a2bd87ddaeaa","question_text":"Population selection**: Should therapy target all PD, only LRRK2 mutation carriers, or all with elevated LRRK2 activity?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-lrrk2-kinase-pathway-parkinsons","evidence_xref_at":"2026-04-27T13:26:58.265187+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:35.422852-07:00","updated_at":"2026-04-25T20:29:35.422852-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:35.422852-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"cd612511-8b6a-429a-b86d-efc65b8380d4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-lrrk2-kinase-pathway-parkinsons","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-gene-therapy","link_type":"candidate_answer","strength":0.92,"evidence":"{\"confidence\": 0.92, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-gene-therapy-comparison","link_type":"candidate_answer","strength":0.92,"evidence":"{\"confidence\": 0.92, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-lrrk2-ind-enabling-studies","link_type":"candidate_answer","strength":0.88,"evidence":"{\"confidence\": 0.88, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-ind-enabling-study","link_type":"candidate_answer","strength":0.88,"evidence":"{\"confidence\": 0.88, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"partial_answer_for","strength":0.78,"evidence":"{\"confidence\": 0.78, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-knockdown","link_type":"candidate_answer","strength":0.9,"evidence":"{\"confidence\": 0.9, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-combination-therapy-sequencing-pd","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-ad98882f-ae10-455c-9c22-716a40dc9c2f","is_canonical":true,"supersede_chain":["open_question-ad98882f-ae10-455c-9c22-716a40dc9c2f"]}