{"artifact":{"id":"open_question-d492953d-13ee-48dc-8d6d-40e3d44eae51","artifact_type":"open_question","entity_ids":"[\"clinical\"]","title":"Biomarker stratification**: Are there biomarker subgroups that respond better to therapy?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"3a2bc9537c6640b343840c2cd3be0fe27d48904f9775e0a30649e3e4744b595f","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:26:32.114761"},"field_tag":"clinical","source_id":"clinical-trials-nio752-psp-tau-aso-nct04539041","sub_field":"trials-nio752-psp-tau-aso-nct04539041","source_kind":"wiki","question_hash":"56ee3deb0e81f82a2a5da8051ec861c0fd945ad9e9c28706f6b43e65a062b5a8","question_text":"Biomarker stratification**: Are there biomarker subgroups that respond better to therapy?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page clinical-trials-nio752-psp-tau-aso-nct04539041","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:26:32.114880-07:00","updated_at":"2026-04-25T20:26:32.114880-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:26:32.114880-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"924b54cc-d1d7-420f-bc6e-d4997b717bdb","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-clinical-trials-nio752-psp-tau-aso-nct04539041","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"incoming_links":[],"current_artifact_id":"open_question-d492953d-13ee-48dc-8d6d-40e3d44eae51","is_canonical":true,"supersede_chain":["open_question-d492953d-13ee-48dc-8d6d-40e3d44eae51"]}