{"artifact":{"id":"open_question-ee470d33-1749-4b81-800e-f1c3bd92f546","artifact_type":"open_question","entity_ids":"[\"diseases\"]","title":"What are the exact mechanisms of prion-like propagation of [alpha-synuclein](/proteins/alpha-synuclein) pathology?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"5b9b88340a387399f30c2a0423ec955d5ae79989ba7dcf770feef47dc6670ffc","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:27:36.615789"},"field_tag":"diseases","source_id":"diseases-parkinson-disease","sub_field":"parkinson-disease","source_kind":"wiki","question_hash":"181c40dd5c0a0b4477f6f1a69fe012f907cf40f0d4d4c33ad08caae11509f561","question_text":"What are the exact mechanisms of prion-like propagation of [alpha-synuclein](/proteins/alpha-synuclein) pathology?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page diseases-parkinson-disease","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:27:36.615898-07:00","updated_at":"2026-04-25T20:27:36.615898-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:27:36.615898-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1b25ea16-30c9-4d21-bfa6-44c09cf7e4e3","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-diseases-parkinson-disease","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"incoming_links":[],"current_artifact_id":"open_question-ee470d33-1749-4b81-800e-f1c3bd92f546","is_canonical":true,"supersede_chain":["open_question-ee470d33-1749-4b81-800e-f1c3bd92f546"]}