{"artifact":{"id":"open_question-f6631d41-1e4d-4bc5-9fad-d379082e44b8","artifact_type":"open_question","entity_ids":"[\"mechanisms\"]","title":"How do other PD genes (LRRK2, GBA, SNCA) interact with the DJ-1-PTEN-P53 network?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"d269dcfa667636baa99d7c71f178768bc234e0c8713a4c2215cbafe56fbcd9fa","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:38.385694"},"field_tag":"mechanisms","source_id":"mechanisms-dj1-pten-p53-network","sub_field":"dj1-pten-p53-network","source_kind":"wiki","question_hash":"ff5b56ac05d0a996a80f630c59931d6c359bf14770d493aa1f5b14566f4836a4","question_text":"How do other PD genes (LRRK2, GBA, SNCA) interact with the DJ-1-PTEN-P53 network?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page mechanisms-dj1-pten-p53-network","evidence_xref_at":"2026-04-27T12:47:55.171321+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:38.385820-07:00","updated_at":"2026-04-25T20:29:38.385820-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:38.385820-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d4c237f0-523e-4f6a-908d-8ab0247d5fda","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-dj1-pten-p53-network","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"partial_answer_for","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"partial_answer_for","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-782e55f6","link_type":"bears_on_question","strength":0.4,"evidence":"{\"confidence\": 0.4, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-e3506e5a","link_type":"candidate_answer","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-0e614ae4","link_type":"bears_on_question","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"hypothesis-h-8bd89d90","link_type":"bears_on_question","strength":0.4,"evidence":"{\"confidence\": 0.4, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-gene-therapy","link_type":"discriminating_experiment","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"partial_answer_for","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-gene-therapy-comparison","link_type":"discriminating_experiment","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-aav-ind-enabling-study","link_type":"discriminating_experiment","strength":0.6,"evidence":"{\"confidence\": 0.6, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-e67da95a-fc6f-457a-9743-1cc6ea90e57f","link_type":"discriminating_experiment","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-aav-serotype-lrrk2-knockdown","link_type":"discriminating_experiment","strength":0.65,"evidence":"{\"confidence\": 0.65, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-1511b30e-82a8-4dbd-a5f6-3a12348e2b3f","link_type":"bears_on_question","strength":0.4,"evidence":"{\"confidence\": 0.4, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-2370b8d3-fa40-4c14-92a7-36bce77cdcd4","link_type":"partial_answer_for","strength":0.5,"evidence":"{\"confidence\": 0.5, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-e1037aba-6e79-4a79-a389-f4ee2f844a81","link_type":"discriminating_experiment","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-f6631d41-1e4d-4bc5-9fad-d379082e44b8","is_canonical":true,"supersede_chain":["open_question-f6631d41-1e4d-4bc5-9fad-d379082e44b8"]}