{"artifact":{"id":"open_question-neurodegeneration-9fe6d49b","artifact_type":"open_question","entity_ids":"[\"neurodegeneration\"]","title":"What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?","quality_score":0.775,"created_by":"open_question_miner_papers","provenance_chain":"[]","content_hash":"e59b7bcb20a60ce40ca6ce0fd79f8587c16ad81f04df1c80422b2e6a87aafcb2","metadata":{"status":"open","_origin":{"url":null,"type":"external","tracked_at":"2026-04-28T06:17:37.633290"},"field_tag":"neurodegeneration","source_id":"37292694","source_doi":"10.21203/rs.3.rs-2921860/v1","source_kind":"paper","question_hash":"9fe6d49b3d333674","question_text":"What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?","importance_elo":1500,"_schema_version":1,"source_paper_id":"paper-e883559ad84c","evidence_summary":"A subset of donors showed a particularly severe cellular and molecular phenotype","tractability_score":0.7,"potential_impact_score":0.85,"is_answerable_in_principle":true},"created_at":"2026-04-27T23:17:37.633364-07:00","updated_at":"2026-04-27T23:17:37.633364-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c76700f0-c0fd-4361-a615-125378943acc","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"open_question_miner_papers"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"open_question-neurodegeneration-9fe6d49b","is_canonical":true,"supersede_chain":["open_question-neurodegeneration-9fe6d49b"]}