{"artifact":{"id":"paper-fig-0afcd4d8-9800-4d88-bf77-743edd20ff15-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2.: Extent of CR-mediated increases in longevity depend on feeding time. (A)  Surviv...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"0afcd4d8-9800-4d88-bf77-743edd20ff15\", \"relation\": \"extracted_from\"}]","content_hash":"33b193a5fab8d5bfa1f3b3e3878eee8e5c212acf62ace34cee8dd17e9c868574","metadata":{"doi":"10.1007/s10522-025-10301-3","pmcid":"9262309","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC9262309/bin/nihms-1820506-f0002.jpg","type":"external","tracked_at":"2026-04-22T23:25:48.576912"},"caption":"Extent of CR-mediated increases in longevity depend on feeding time. (A)  Survival curves for each group (n = 43 for AL and n = 36 for each of the CR) are shown in left panel with median lifespan (days) inset. Right panel summarizes the results, showing the increase in lifespan from timed feeding with the largest increase when food is restricted to night.  (B)  Correlation plots comparing lifespan (days) for each mouse with its daily averaged total activity (counts/min) at different ages. Increased activity significantly correlates with longer lifespan in older (but not young) mice in all groups (see asterisks, Spearman correlation).  (C)  Necropsy followed by histopathology results showing pathologies and diseases (left) and tissues mostly affected (right) at time of death for each feeding condition.","paper_id":"0afcd4d8-9800-4d88-bf77-743edd20ff15","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9262309/bin/nihms-1820506-f0002.jpg","image_path":"","description":"","figure_label":"Fig. 2.","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T16:25:48.577017-07:00","updated_at":"2026-04-22T16:25:48.577017-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9262309/bin/nihms-1820506-f0002.jpg","lifecycle_changed_at":"2026-04-22T16:25:48.577017-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"04ecb454-faf4-4d25-82d4-d8c74b5c4897","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-0afcd4d8-9800-4d88-bf77-743edd20ff15-2","is_canonical":true,"supersede_chain":["paper-fig-0afcd4d8-9800-4d88-bf77-743edd20ff15-2"]}