{"artifact":{"id":"paper-fig-20a37cef-ee77-4d5e-88d9-391adc1ab02d-11","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 11: Effect of AMI treatment on intestinal barrier disruption and subsequent serum LP...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"20a37cef-ee77-4d5e-88d9-391adc1ab02d\", \"relation\": \"extracted_from\"}]","content_hash":"91bc054e45906971f9050f0c4d3b360990a0f7e6b97154183dc2cda2c40ae5f6","metadata":{"doi":"10.1007/s11481-025-10270-x","pmcid":"PMC12764700","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12764700/bin/11481_2025_10270_Fig11_HTML.jpg","type":"external","tracked_at":"2026-04-22T22:49:35.497362"},"caption":"Effect of AMI treatment on intestinal barrier disruption and subsequent serum LPS levels associated with tauopathy in P301S mice. ( a ) Photomicrographs showing the expression of claudin-1 and ZO-1 tight junction proteins in distal colon in the three experimental groups (400X scale bar = 50 μm). ( b ) A graph showing the percentage area of immunostaining for claudin-1 tight junction protein in distal colon in the three experimental groups. ( c ) A graph showing the percentage area of immunostaining for ZO-1 tight junction protein in distal colon in the three experimental groups. ( d ) serum LPS levels in the three experimental groups All data are presented as a mean ± SD. ( n  = 6). One-way analysis of variance (ANOVA) was used to determine statistical significance, followed by Tukey’s multiple comparison analysis. A p-value below 0.05 was considered significant where *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.001, ****p ≤ 0.001","paper_id":"20a37cef-ee77-4d5e-88d9-391adc1ab02d","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12764700/bin/11481_2025_10270_Fig11_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 11","figure_number":11,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T15:49:35.497474-07:00","updated_at":"2026-04-22T15:49:35.497474-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12764700/bin/11481_2025_10270_Fig11_HTML.jpg","lifecycle_changed_at":"2026-04-22T15:49:35.497474-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"0e1d9077-a09c-4b7b-8483-18a3e9f77cd9","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-20a37cef-ee77-4d5e-88d9-391adc1ab02d-11","is_canonical":true,"supersede_chain":["paper-fig-20a37cef-ee77-4d5e-88d9-391adc1ab02d-11"]}