{"artifact":{"id":"paper-fig-23402e4f-47bc-4793-ad72-fa8ce1bf1f80-9","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 9 — Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hip","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"23402e4f-47bc-4793-ad72-fa8ce1bf1f80\", \"timestamp\": \"2026-04-22T01:29:41.277639\"}]","content_hash":null,"metadata":{"pmid":"23402e4f-47bc-4793-ad72-fa8ce1bf1f80","caption":"Immunohistochemical Detection of the Expression of Genes Related to Adipogenesis. Rats were divided into six groups: control, resveratrol (100 μmol/L), and ICA (1, 10, 50, 100 μmol/L). Tissue samples were collected at 10, 14, and 21 days for immunohistochemical analysis.  (A)  Expression of the adipogenesis-related gene PPARγ detected by immunohistochemistry (Left: Microscope ×100, Scale = 200 μm; Right: Microscope ×400, Scale = 50 μm).  (B)  Quantitative analysis of the PPARγ-positive cell area. The data were obtained from multiple analyses (n = 3). Statistical significance is indicated by: * p  < 0.05, ** p  < 0.01 vs. the control group; # p  < 0.05, ## p  < 0.01 vs. the RES group.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11770256/bin/fphar-15-1510561-g009.jpg","paper_title":"Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP/TAZ pathway: a novel therapeutic strategy for osteoporosis.","figure_label":"FIGURE 9","figure_number":9,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9f196630-2df8-421a-aea0-3afc7a1741fa","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-23402e4f-47bc-4793-ad72-fa8ce1bf1f80-9","is_canonical":true,"supersede_chain":["paper-fig-23402e4f-47bc-4793-ad72-fa8ce1bf1f80-9"]}