{"artifact":{"id":"paper-fig-277d6fab-2b93-4984-bc0b-4c0c08a75d1b-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2. — Mitochondrial function in development and disease.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"277d6fab-2b93-4984-bc0b-4c0c08a75d1b\", \"timestamp\": \"2026-04-22T01:29:41.227801\"}]","content_hash":null,"metadata":{"pmid":"277d6fab-2b93-4984-bc0b-4c0c08a75d1b","caption":"Organization and replication of the human mitochondrial genome.  (A) Map of mtDNA. The black arrows point to the nucleotides affected in the indicated diseases; the black bar depicts the span of the ‘common deletion’ in mtDNA, which accounts for a third of Kearns-Sayre syndrome (KSS) cases (see  Table 3 ). HSP, H-strand promoter; LHON, Leber hereditary optic neuropathy; LSP, L-strand promoter; MELAS, Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes; MERFF, myoclonic epilepsy with ragged red fibers; NCR, non-coding control region (also known as D-loop region); PEO, progressive external ophthalmoplegia. (B) Strand displacement model of mtDNA replication. After initiation of replication at O H  by an RNA primer transcribed by mitochondrial DNA-directed RNA polymerase (POLRMT), POLRMT is replaced by Polγ, which synthesizes the full-length nascent daughter heavy (H)-strand using the light (L)-strand DNA as the template, with the Twinkle helicase moving on the","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC8214736/bin/dmm-14-048912-g2.jpg","paper_title":"Mitochondrial function in development and disease.","figure_label":"Fig. 2.","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ffda45bc-fab6-453e-bbc9-46784ccd57c4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-277d6fab-2b93-4984-bc0b-4c0c08a75d1b-2","is_canonical":true,"supersede_chain":["paper-fig-277d6fab-2b93-4984-bc0b-4c0c08a75d1b-2"]}