{"artifact":{"id":"paper-fig-32863951-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1: The cytosolic DNA-sensing pathway is upregulated in microglia after cerebral isc...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"32863951\", \"relation\": \"extracted_from\"}]","content_hash":"938f6cfe76bab04f14f793394b251037474907c0a91f00b98a42d3cc5ba8a434","metadata":{"doi":"10.7150/thno.47651","pmid":"32863951","pmcid":"PMC7449914","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC7449914/bin/thnov10p9644g001.jpg","type":"external","tracked_at":"2026-04-12T00:38:58.996865"},"caption":"The cytosolic DNA-sensing pathway is upregulated in microglia after cerebral ischemia/reperfusion (I/R).  ( A ) Kyoto encyclopedia of genes and genomes (KEGG) analysis of the upregulated genes from the RNA sequencing data of adult primary microglia isolated from the brains of mice that underwent tMCAO (10 mice for each sample). ( B ) Gene set enrichment analysis showed that the cytosolic DNA sensing pathway was upregulated in microglia isolated from mice subjected to tMCAO (Sham: the brain underwent sham operation; Contra: the contralateral side of the brain underwent I/R; Lateral: the side of the brain underwent I/R). ( C ) Genes involved in the cytosolic DNA sensing pathway were upregulated in microglia isolated from mice subjected to tMCAO. ( D and E ) Ischemic penumbra cortex was collected from mice that underwent tMCAO at different time points post-reperfusion, and the mRNA levels of IFN-β (D) and IL-6 (E) were quantified by real-time PCR (* indicates  p  < 0.05, ** indicates  p  ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC7449914/bin/thnov10p9644g001.jpg","image_path":"","description":"","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-11T17:38:59-07:00","updated_at":"2026-04-18T21:54:00.100607-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC7449914/bin/thnov10p9644g001.jpg","lifecycle_changed_at":"2026-04-11T17:38:59-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"45a2b77b-8132-4a5c-bd2a-df26eac642b7","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-32863951","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 32863951"}],"incoming_links":[],"current_artifact_id":"paper-fig-32863951-1","is_canonical":true,"supersede_chain":["paper-fig-32863951-1"]}