{"artifact":{"id":"paper-fig-36747024-10","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 5: SPP1 deficiency prevents synapse loss upon oAβ challenge. (a ) Scheme illustrati...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"36747024\", \"relation\": \"extracted_from\"}]","content_hash":"d215a238f31a129949b705c669c51668f4910cbbf211c7a5a96d9e6576a7a33b","metadata":{"doi":"","pmcid":"PMC9991912","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig10_ESM.jpg","type":"external","tracked_at":"2026-04-15T23:28:06.336410"},"caption":"SPP1 deficiency prevents synapse loss upon oAβ challenge. (a ) Scheme illustrating tail vein (TV) injection of 100ng S26C oAβ versus PBS in WT versus  Spp1 KO/KO  mice, 72 h before tissue collection and analysis.  (b)  Representative super-resolution images of Homer1 and Bassoon puncta colocalization in 3 mo WT and  Spp1 KO/KO  SR injected with oAβ versus PBS control, at 72 h post-TV injection. Scale bar represents 5 µm. ( c ) Quantification of Homer1/Bassoon colocalization density, represented as S26C oAβ-injected mice normalized to PBS injected mice. 1 datapoint represents the average of 1 animal (3–5 ROIs per animal, 40 cells per ROI) with a total of n = 4 mice per genotype. Data are from one experiment.  P  Values from multiple unpaired  t -tests, Bonferroni’s multiple comparison test. Data are shown as Mean ± SEM. \n Source data","paper_id":"36747024","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig10_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 5","figure_number":10,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-15T23:28:06-07:00","updated_at":"2026-04-16T21:02:10.792794-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig10_ESM.jpg","lifecycle_changed_at":"2026-04-15T23:28:06-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1d920872-4834-41a8-a688-84c9ba4a4b03","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-36747024","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 36747024"}],"incoming_links":[],"current_artifact_id":"paper-fig-36747024-10","is_canonical":true,"supersede_chain":["paper-fig-36747024-10"]}