{"artifact":{"id":"paper-fig-36747024-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 1: Pre-plaque vascular Aβ deposition in  App NL-F  mice. (a ,  b)  Quantification o...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"36747024\", \"relation\": \"extracted_from\"}]","content_hash":"5f5d74c96738d893ee5a8192208317526eeab3b1e08bae2d5d8bddff37a965de","metadata":{"doi":"","pmcid":"PMC9991912","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig6_ESM.jpg","type":"external","tracked_at":"2026-04-15T23:28:06.274382"},"caption":"Pre-plaque vascular Aβ deposition in  App NL-F  mice. (a ,  b)  Quantification of SPP1 immunoreactivity in CA1 hippocampus  (a)  versus cerebellum as control region  (b) , as measured by confocal imaging. 1 datapoint represents 1 ROI per mouse hippocampus, with total of 8 (CA1,  a ) and 7 (CRB,  b ) mice per genotype examined over 2 independent experiments.  P  Values from linear mixed-effect model with multivariate t-distribution post-hoc test. Data are shown as Mean ± SEM.  (c)  Validation of SPP1 antibody (left) and anti- Spp1  probe for smFISH (right) in 3 mo  Spp1 KO/KO  hippocampal tissue. Scale bar represents 10 µm. Data representative of n = 4  Spp1 KO/KO  mice examined over 1 independent experiment.  (d)  Representative confocal image of  Spp1  mRNA expression along GLUT1 +  vasculature in SLM of 6 mo  App NL-F  mice as characterized by smFISH-IHC. Scale bar represents 20 µm. Insert: 3D reconstruction. Scale bar represents 5 µm. Data are representative of 3  App NL-F  mice exa","paper_id":"36747024","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig6_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 1","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-15T23:28:06-07:00","updated_at":"2026-04-16T21:02:10.792794-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig6_ESM.jpg","lifecycle_changed_at":"2026-04-15T23:28:06-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e3210cc2-0843-4d82-bbc4-ee46ef232b9f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-36747024","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 36747024"}],"incoming_links":[],"current_artifact_id":"paper-fig-36747024-6","is_canonical":true,"supersede_chain":["paper-fig-36747024-6"]}