{"artifact":{"id":"paper-fig-36747024-7","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 2: Spp1  is expressed in perivascular cells. (a)  Representative confocal image sho...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"36747024\", \"relation\": \"extracted_from\"}]","content_hash":"7eecaaf813fd2ddcf60a3858d330671e37b6832f3c01b5eadb7cde2d0d8f5e31","metadata":{"doi":"","pmcid":"PMC9991912","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig7_ESM.jpg","type":"external","tracked_at":"2026-04-15T23:28:06.289739"},"caption":"Spp1  is expressed in perivascular cells. (a)  Representative confocal image showing  Spp1  and  Tmem119  mRNA expression within P2Y12 +  microglia of 6 mo  App NL-F  SLM as characterized by smFISH-IHC. Scale bar represents 20 µm. Data representative of n = 8  App NL-F  mice examined over 3 independent experiments.  (b)  Representative confocal image showing  Spp1  mRNA in P2Y12 microglia associated with 6E10 +  plaques in 15 mo  App NL-F  SLM. Scale bar represents 5 µm. Data representative of n = 3  App NL-F  mice examined over 2 independent experiments.  (c)  Representative confocal images of SPP1 protein expression in CD206 +  PVMs (arrow head) and CX3CR1 GFP  myeloid cells of 3 mo  Cx3cr1 GFP/WT  SLM 86 . Scale bar represents 20 µm. Data are representative of n = 2  Cx3cr1 GFP/WT  mice examined over at least 3 independent experiments.  (d)  Representative confocal image showing  Spp1  mRNA expression occasionally colocalizing with pan-PVM markers  Cd163  and  Pf4 in  6 mo  App NL-F","paper_id":"36747024","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig7_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 2","figure_number":7,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-15T23:28:06-07:00","updated_at":"2026-04-16T21:02:10.792794-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig7_ESM.jpg","lifecycle_changed_at":"2026-04-15T23:28:06-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1ba8a836-6b41-4f8c-8c27-ce191aa1886a","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-36747024","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 36747024"}],"incoming_links":[],"current_artifact_id":"paper-fig-36747024-7","is_canonical":true,"supersede_chain":["paper-fig-36747024-7"]}