{"artifact":{"id":"paper-fig-37245027-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 6: PA lung infection causes systemic and neuroinflammation.  a – c  PA-induced plas...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"37245027\", \"relation\": \"extracted_from\"}]","content_hash":"fd88b5765c10657fb3d706d626743d20464df1af987f8ad1e354e86cfdf26956","metadata":{"doi":"","pmcid":"PMC10223932","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig6_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:39.726426"},"caption":"PA lung infection causes systemic and neuroinflammation.  a – c  PA-induced plasma levels of IL-1β, IL-6 and TNF-α at different time points after infection (OD 600  0.3) compared to uninfected controls. Kruskal–Wallis test, P = 0.01, P = 0.001 and P = 0.0009 vs. control (uninfected) group.  d – f  mRNA expression levels of ( d ) cytokines (IL-1β, IL-6 and TNF-α), ( e ) chemokines (CXCL1 and CXCL2) and ( f ) adhesion molecules (ICAM-1 and VCAM-1) in cortex from control and infected. Mann–Whitney test, P = 0.004, P = 0.03, P = 0.001, P = 0.001, P = 0.02 vs. control (uninfected) group.  g – i  mRNA expression levels of ( g ) cytokines (IL-1β, IL-6 and TNF-α), ( h ) chemokines (CXCL1 and CXCL2) and ( i ) adhesion molecules (ICAM-1 and VCAM-1) in hippocampus from control and infected mice. Mann–Whitney test, P = 0.01, P = 0.005 vs. control (uninfected) group. In all graphs, each point indicates data from an individual animal bar graphs (columns and error bars) show mean ± S.E.M","paper_id":"37245027","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig6_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:39-07:00","updated_at":"2026-04-16T21:02:10.792794-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig6_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:39-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"078ec2af-e6b0-4e7b-a6ba-2d09e879adb9","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-37245027","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 37245027"}],"incoming_links":[],"current_artifact_id":"paper-fig-37245027-6","is_canonical":true,"supersede_chain":["paper-fig-37245027-6"]}