{"artifact":{"id":"paper-fig-37245027-7","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 7: Effect of proinflammatory cytokines on brain microvascular endothelial barrier f...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"37245027\", \"relation\": \"extracted_from\"}]","content_hash":"8ef3db56a60a03be93cd8e709480cd71b8aac00d9c8429ceae649ea3539cedf7","metadata":{"doi":"","pmcid":"PMC10223932","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig7_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:39.746599"},"caption":"Effect of proinflammatory cytokines on brain microvascular endothelial barrier function.  a  TER measurements across confluent monolayers of mouse brain microvascular endothelial cells treated with IL-1β (2–200 ng/mL) and IL-1β + TNF-α (20 ng/mL each). The data were represented as resistance change. Mean ± S.E.M., n = 3. Arrow indicates when cytokines were added.  b  Summary data showing TER changes in brain microvascular endothelial cells treated with IL-1β and IL-1β + TNF-α. Kruskal–Wallis test with Dunn’s multiple comparisons test, P < 0.0001, IL-1β (2–200 ng/mL) vs. control (vehicle) group; P < 0.0001, IL-1β + TNF-α (20 ng/mL each) vs. control (vehicle).  c  Immunocytochemical analysis of claudin-5, VE-cadherin and ZO-1 (red) on brain microvascular endothelial cells under control conditions (vehicle) and after IL-1β (20 ng/mL) treatment in vitro. Nuclei was stained with DAPI. White arrows indicate TJ disorganization","paper_id":"37245027","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig7_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 7","figure_number":7,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:39-07:00","updated_at":"2026-04-16T21:02:10.792794-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10223932/bin/12974_2023_2817_Fig7_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:39-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"8a6eaccf-be63-421c-9fe5-5aad926265fa","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-37245027","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 37245027"}],"incoming_links":[],"current_artifact_id":"paper-fig-37245027-7","is_canonical":true,"supersede_chain":["paper-fig-37245027-7"]}