{"artifact":{"id":"paper-fig-37847372-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: Proposed C9ORF72 disease mechanisms. The  C9ORF72  (GGGGCC) hexanucleotide repea...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"37847372\", \"relation\": \"extracted_from\"}]","content_hash":"09733786fc1ddf0584e2305ad93ed2dd7ddcb427712a8ebf41227e330f75d3e4","metadata":{"doi":"","pmcid":"PMC10630271","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC10630271/bin/40120_2023_548_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-12T11:58:30.391184"},"caption":"Proposed C9ORF72 disease mechanisms. The  C9ORF72  (GGGGCC) hexanucleotide repeat expansion is thought to contribute to disease pathogenesis in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) via three non-mutually exclusive mechanisms: (1) a loss of function due to impaired transcription leading to a reduction in C9ORF72 protein levels; (2) a toxic gain of function due to the formation of secondary RNA structures which sequester RNA binding proteins and consequently a loss of function of these proteins; (3) a toxic gain of function due to repeat-associated non-ATG (RAN) translation from both the sense and antisense strand, which generates potentially toxic dipeptide repeats (DPRs; poly-GP, poly-GA, poly-GR, poly-PA, poly-PR)","paper_id":"37847372","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10630271/bin/40120_2023_548_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-12T04:58:30-07:00","updated_at":"2026-04-18T21:52:59.103644-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10630271/bin/40120_2023_548_Fig1_HTML.jpg","lifecycle_changed_at":"2026-04-12T04:58:30-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e447a57f-4d8b-4799-a82e-26196b233420","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-37847372","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 37847372"}],"incoming_links":[],"current_artifact_id":"paper-fig-37847372-1","is_canonical":true,"supersede_chain":["paper-fig-37847372-1"]}