{"artifact":{"id":"paper-fig-39427196-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 4: Inhibition of NF-κB pathway in vivo restores brain endothelial Wnt/β-catenin sig...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"39427196\", \"relation\": \"extracted_from\"}]","content_hash":"7a75a95d82eb96a09196a798467b015b6b91cbccb8ef51302d81c5f17387f9bf","metadata":{"doi":"","pmcid":"PMC11491032","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig4_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:41.927139"},"caption":"Inhibition of NF-κB pathway in vivo restores brain endothelial Wnt/β-catenin signaling and attenuates LPS-induced BBB leakage and neuroinflammation.  A , Schematic illustration of experimental design. The NF-κB pathway inhibitor BAY 11-7085 (5 mg/kg) or vehicle control (DMSO) was intraperitoneally (i.p.) injected to mice at 30 min after LPS or saline injection.  B , Mortality rate of mice at 24 h following vehicle ( n  = 10 mice), LPS + vehicle ( n  = 14 mice), or LPS + BAY 11-7085 ( n  = 15 mice) treatment.  C , Body weight change of the mice at 24 h after vehicle ( n  = 10 mice), LPS + vehicle ( n  = 9 mice), or LPS + BAY 11-7085 ( n  = 10 mice) treatment.  D , Co-immunofluorescence staining of NF-κB p65 and CD31 in the brain cortex and its quantifications. NF-κB p65 signal in endothelial cells was selectively quantified.  E , Co-immunofluorescence staining of VCAM1 and CD31 in the brain cortex and its quantifications.  F , Co-immunofluorescence staining of LEF1 and CD31 in the brain","paper_id":"39427196","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig4_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:41-07:00","updated_at":"2026-04-16T20:55:17.546747-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig4_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:41-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"46246f3a-988a-434b-95f4-484f5acdfd11","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-39427196","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 39427196"}],"incoming_links":[],"current_artifact_id":"paper-fig-39427196-4","is_canonical":true,"supersede_chain":["paper-fig-39427196-4"]}